α-羟基美托洛尔(非对映异构体混合物)结构式
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常用名 | α-羟基美托洛尔(非对映异构体混合物) | 英文名 | UNII:C19D0413EL |
|---|---|---|---|---|
| CAS号 | 56392-16-6 | 分子量 | 283.363 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 437.6±45.0 °C at 760 mmHg | |
| 分子式 | C15H25NO4 | 熔点 | 65-67ºC | |
| MSDS | 美版 | 闪点 | 218.4±28.7 °C |
用途a-Hydroxymetoprolol 是美托洛尔的代谢产物。a-Hydroxymetoprolol 对美托洛尔的肾上腺素受体阻断作用几乎为零。 |
| 中文名 | A-羟基美托洛尔 |
|---|---|
| 英文名 | α-Hydroxy Metoprolol |
| 中文别名 | Alpha-羟基美托洛尔 |
| 英文别名 | 更多 |
| 密度 | 1.1±0.1 g/cm3 |
|---|---|
| 沸点 | 437.6±45.0 °C at 760 mmHg |
| 熔点 | 65-67ºC |
| 分子式 | C15H25NO4 |
| 分子量 | 283.363 |
| 闪点 | 218.4±28.7 °C |
| 精确质量 | 283.178345 |
| PSA | 70.95000 |
| LogP | 0.72 |
| 外观性状 | 白色固体 |
| 蒸汽压 | 0.0±1.1 mmHg at 25°C |
| 折射率 | 1.524 |
| 储存条件 | -20°C Freezer |
| 危险品运输编码 | NONH for all modes of transport |
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~95%
α-羟基美托洛尔(非对映异构体混合物) 56392-16-6 |
| 文献：Shetty, H. Umesha; Nelson, Wendel L. Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 55 - 59 |
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α-羟基美托洛尔(非对映异构体混合物) 56392-16-6 |
| 文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59 |
|
~%
α-羟基美托洛尔(非对映异构体混合物) 56392-16-6 |
| 文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59 |
|
~%
α-羟基美托洛尔(非对映异构体混合物) 56392-16-6 |
| 文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59 |
|
~%
α-羟基美托洛尔(非对映异构体混合物) 56392-16-6 |
| 文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59 |
|
~%
α-羟基美托洛尔(非对映异构体混合物) 56392-16-6 |
| 文献：Journal of Medicinal Chemistry, , vol. 31, # 1 p. 55 - 59 |
|
~%
α-羟基美托洛尔(非对映异构体混合物) 56392-16-6 |
| 文献：European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442 |
| α-羟基美托洛尔(非对映异构体混合物)上游产品 6 | |
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| α-羟基美托洛尔(非对映异构体混合物)下游产品 0 | |
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Simultaneous determination of metoprolol and α-hydroxymetoprolol in human plasma using excitation-emission matrix fluorescence coupled with second-order calibration methods.
Bioanalysis 4(23) , 2781-93, (2012) Metoprolol (MET) is a β1-adrenoceptor antagonist, which is widely used in the treatment of cardiovascular diseases, and α-hydroxymetoprolol (α-OHM) is its hydroxylated metabolite. Owing to their simil... |
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Metoprolol oxidation polymorphism in Brazilian elderly cardiac patients.
J. Pharm. Pharmacol. 65(9) , 1347-53, (2013) The purpose of this study was to phenotype the CYP2D6 in elderly with heart disease classified as extensive metabolizer or poor metabolizers (PM) of metoprolol, develop and validate the method of anal... |
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Variation of pharmacokinetics after oral administration of slow-release metoprolol tablets and pharmacogenetic considerations.
Arzneimittelforschung 42(6) , 802-6, (1992) The maximum plasma concentrations (Cmax) after oral administration of 120 mg tablets of slow-release metoprolol (CAS 37350-58-6) to 75 Japanese healthy male volunteers and 15 arrhythmic patients were ... |
| 1-[4-(1-Hydroxy-2-methoxyethyl)phenoxy]-3-(isopropylamino)-2-propanol |
| 3-[4-(1-Hydroxy-2-methoxyethyl)phenoxy]-1-isopropylamino-2-propanol |
| Benzenemethanol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-α-(methoxymethyl)- |
| α-HYDROXYMETOPROLOL |
| 1-[4-(1-hydroxy-2-methoxyethyl)phenoxy]-3-(isopropylamino)propan-2-ol |
| UNII:C19D0413EL |
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