Malonyl CoA

• 常用名: Malonyl CoA
• 英文名: Malonyl CoA
• CAS号: 524-14-1
• 分子量: 853.58000
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₈N₇O₁₉P₃S
• 熔点: N/A
• 闪点: N/A

Malonyl CoA用途

丙二酰辅酶a是脂肪酸生物合成的底物和脂肪酸氧化的抑制剂。丙二酰辅酶a也是线粒体肉碱棕榈酰转移酶(CPT)的可逆抑制剂[1][2]。

Malonyl CoA名称

• 英文名: malonyl-CoA

Malonyl CoA生物活性

• 描述: 丙二酰辅酶a是脂肪酸生物合成的底物和脂肪酸氧化的抑制剂。丙二酰辅酶a也是线粒体肉碱棕榈酰转移酶(CPT)的可逆抑制剂[1][2]。
• 相关类别:
  研究领域 >> 代谢疾病
• 靶点:

  Human Endogenous Metabolite

• 体外研究: 丙二酰辅酶A(20μM,6分钟) 抑制 MCF-7型细胞 每分钟1次活性 (降低 75%)[2]. 丙二酰辅酶A(0-3μM)抑制雌性大鼠肝线粒体中的 每分钟1次活性[3].
• 参考文献:

  [1]. Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87.

  [2]. Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23.

  [3]. Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6.

Malonyl CoA物理化学性质

• 分子式: C₂₄H₃₈N₇O₁₉P₃S
• 分子量: 853.58000
• 精确质量: 853.11600
• PSA: 455.66000

Malonyl CoA英文别名

• 2,6-Dioxo-cyclohexancarbaldehyd
• 2-formyl-1,3-cyclohexanedione
• 2,6-dioxo-cyclohexanecarbaldehyde
• S-(HYDROGEN MALONYL)COENZYME A
• 3-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxopropanoicacid
• S-(HYDROGEN MALONYL)COENZYME A