琥珀酸拉米丹

• 常用名: 琥珀酸拉米丹
• 英文名: Lasmiditan hemisuccinate
• CAS号: 439239-92-6
• 分子量: 872.80900
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₂H₄₂F₆N₆O₈
• 熔点: N/A
• 闪点: N/A

琥珀酸拉米丹用途

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.

琥珀酸拉米丹名称

• 中文名: 琥珀酸拉米丹
• 英文名: butanedioic acid,2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide

琥珀酸拉米丹物理化学性质

• 分子式: C₄₂H₄₂F₆N₆O₈
• 分子量: 872.80900
• 精确质量: 872.29700
• PSA: 206.18000
• LogP: 7.13100
• InChIKey: MSOIHUHNGPOCTH-UHFFFAOYSA-N
• SMILES: CN1CCC(C(=O)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1.CN1CCC(C(=O)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1.O=C(O)CCC(=O)O
• 储存条件: -20°C， 密封， 干燥

琥珀酸拉米丹英文别名

• Lasmiditan succinate (USAN)
• 2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide hemisuccinate
• UNII-W64YBJ346B
• Lasmiditan succinate
• Lasmiditan hemisuccinate