GKK1032B

• 常用名: GKK1032B
• 英文名: GKK1032B
• CAS号: 358375-11-8
• 分子量: 501.656
• 密度: 1.1±0.1 g/cm3
• 沸点: 653.9±55.0 °C at 760 mmHg
• 分子式: C₃₂H₃₉NO₄
• 熔点: N/A
• 闪点: 349.3±31.5 °C

GKK1032B用途

GKK1032B是一种生物碱化合物,可在内生真菌青霉中发现。GKK1032B可通过激活半胱天冬酶途径诱导人骨肉瘤MG63细胞凋亡[1]。

GKK1032B名称

• 英文名: GKK1032B

GKK1032B生物活性

• 描述: GKK1032B是一种生物碱化合物,可在内生真菌青霉中发现。GKK1032B可通过激活半胱天冬酶途径诱导人骨肉瘤MG63细胞凋亡[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Qi X, et, al. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. J Antibiot (Tokyo). 2019 Apr;72(4):237-240.

  [2]. Liu N, et, al. GKK1032B from endophytic Penicillium citrinum induces the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation. Chin J Nat Med. 2022 Jan;20(1):67-73.

GKK1032B物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 653.9±55.0 °C at 760 mmHg
• 分子式: C₃₂H₃₉NO₄
• 分子量: 501.656
• 闪点: 349.3±31.5 °C
• 精确质量: 501.287903
• LogP: 7.78
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.560

GKK1032B英文别名

• 5,8-Ethenofluoreno[9',1':2,3,4]oxacyclododecino[6,7-c]pyrrole-1,3,17(2H,4H,10H)-trione, 16-ethenyl-3a,9a,9b,11,12,13,13a,13b,16,16a,16b,17a-dodecahydro-10,12,13a,14,16-pentamethyl-, (3aS,9aS,9bR,10S,12R,13aS,13bS,16S,16aR,16bS,17aR)-
• GKK1032B
• (3S,4R,5S,7R,9S,10S,13S,14R,16R,20S,27S)-5,7,9,11,13-Pentamethyl-13-vinyl-2-oxa-18-azahexacyclo[20.2.2.13,10.04,9.014,27.016,20]heptacosa-1(24),11,22,25-tetraene-15,17,19-trione