5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]1,3-氧硫杂环戊-2-甲酸孟酯

• 常用名: 5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]1,3-氧硫杂环戊-2-甲酸孟酯
• 英文名: (2R-CIS)-5-(4-AMINO-1,2-DIHYDRO-2-OXO-1-PYRIMIDINYL)
• CAS号: 147027-10-9
• 分子量: 381.490
• 密度: 1.4±0.1 g/cm3
• 沸点: 525.0±60.0 °C at 760 mmHg
• 分子式: C₁₈H₂₇N₃O₄S
• 熔点: 203-210°C
• 闪点: 271.3±32.9 °C

名称

• 中文名: 5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]1,3-氧硫杂环戊-2-甲酸孟酯
• 英文名: (2R,5S)-L-Methyl-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
• 中文别名: 氧硫杂环戊烷-2-羧酸-L-薄荷酯 | 5-(4-氨基-2-氧代-2H-嘧啶-1-基)-(1,3)1,3-氧硫杂环戊-2-甲酸孟酯 | 拉米夫定中间体 | (2R,5R)-5-(4-氨基-2-氧代-2H-嘧啶-1-基)-[1,3]-氧硫杂环戊-2-甲酸孟酯 | 拉米夫定中间体(CME)

物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 525.0±60.0 °C at 760 mmHg
• 熔点: 203-210°C
• 分子式: C₁₈H₂₇N₃O₄S
• 分子量: 381.490
• 闪点: 271.3±32.9 °C
• 精确质量: 381.172241
• PSA: 121.74000
• LogP: 3.47
• 外观性状: 黄褐色固体
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.655
• 储存条件: -20°C Freezer

英文别名

• 2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
• 5-methyl-2-(propan-2-yl)cyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate
• (1R,2S,5R)-Menthyl-(2R,5S)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid
• 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, (5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2R,5S)-
• MFCD00869739
• (5R)-2-Isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylate
• 1,3-Oxathiolane-2-carboxylic acid, 5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-, 5-methyl-2-(1-methylethyl)cyclohexyl ester
• 2-Isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate
• (2R-CIS)-5-(4-AMINO-1,2-DIHYDRO-2-OXO-1-PYRIMIDINYL)
• Emtricitabine Impurity 24