SGK1 Inhibitor

• 常用名: SGK1 Inhibitor
• 英文名: SGK1 Inhibitor
• CAS号: 1426214-51-8
• 分子量: 435.287
• 密度: 1.7±0.1 g/cm3
• 沸点: 730.5±70.0 °C at 760 mmHg
• 分子式: C₁₇H₁₂Cl₂N₆O₂S
• 熔点: N/A
• 闪点: 395.6±35.7 °C

SGK1 Inhibitor用途

SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719.

SGK1 Inhibitor名称

• 英文名: SGK1 Inhibitor

SGK1 Inhibitor物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 730.5±70.0 °C at 760 mmHg
• 分子式: C₁₇H₁₂Cl₂N₆O₂S
• 分子量: 435.287
• 闪点: 395.6±35.7 °C
• 精确质量: 434.011963
• LogP: 3.81
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.750

SGK1 Inhibitor英文别名

• N-[4-(3-Amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichlorobenzenesulfonamide
• MFCD31615459
• Benzenesulfonamide, N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-2,3-dichloro-
• SGK1 Inhibitor