N3PT

• 常用名: N3PT
• 英文名: N3PT
• CAS号: 13860-66-7
• 分子量: 336.28000
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₁₉Cl₂N₃OS
• 熔点: N/A
• 闪点: N/A

N3PT用途

N3PT(N3-pyridyl thiamine)是转酮醇酶（TK）抑制剂，对Apo-TK的IC50为22 nM。

N3PT名称

• 中文名: N3PT
• 英文名: 3-[(2-Amino-6-methyl-3-pyridinyl)methyl]-5-(2-hydroxyethyl)-4-met hyl-1,3-thiazol-3-ium chloride hydrochloride (1:1:1)

N3PT生物活性

• 描述: N3PT(N3-pyridyl thiamine)是转酮醇酶(TK)抑制剂,对Apo-TK的IC50为22 nM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Allen A. Thomas, Josh Ballard, Bryan Bernat. Potent and Selective Thiamine Antagonists That Inhibit Transketolase.

  [2]. Jeno Gyuris, May Han, Ronan C, N3-pyridyl-thiamine and its use in cancer treatments. Patent Numeber: WO2005094803 A2

  [3]. Thomas AA, De Meese J, Le Huerou Y, Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett. 2008 Jan 15;18(2):509-12.

N3PT物理化学性质

• 分子式: C₁₃H₁₉Cl₂N₃OS
• 分子量: 336.28000
• 精确质量: 335.06300
• PSA: 91.26000
• InChIKey: ZLGKCAQWOASSTP-UHFFFAOYSA-M
• SMILES: Cc1ccc(C[n+]2csc(CCO)c2C)c(N)n1.Cl.[Cl-]
• 储存条件: 2-8℃

N3PT英文别名

• 3-(2-amino-6-methyl-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazolium,chloride hydrochloride
• 2-(2H-pyrazol-3-yl)-5-(trifluoromethyl)aniline
• 3-(2-Amino-6-methyl-[3]pyridylmethyl)-5-(2-hydroxy-aethyl)-4-methyl-thiazolium,Chlorid-hydrochlorid
• 3-(2-amino-6-methyl-pyridin-3-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium chloride hydrochloride
• 2-(1(2)H-pyrazol-3-yl)-5-trifluoromethyl-aniline
• 3-(2-Amino-4-trifluormethylphenyl)pyrazol
• 3-(2-amino-6-methyl-[3]pyridylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazolium,chloride-hydrochloride
• N3PT