SAR405838

• 常用名: SAR405838
• 英文名: SAR 405838
• CAS号: 1303607-60-4
• 分子量: 562.503
• 密度: 1.4±0.1 g/cm3
• 沸点: 732.1±60.0 °C at 760 mmHg
• 分子式: C₂₉H₃₄Cl₂FN₃O₃
• 熔点: N/A
• 闪点: 396.6±32.9 °C

SAR405838用途

SAR405838是一种高效的选择性MDM2抑制剂, 与MDM2结合, Ki值为0.88 nM。

SAR405838名称

• 中文名: SAR405838
• 英文名: mi-77301

SAR405838生物活性

• 描述: SAR405838是一种高效的选择性MDM2抑制剂, 与MDM2结合, Ki值为0.88 nM。
• 相关类别:
  信号通路 >> 细胞凋亡 >> MDM-2/p53
  研究领域 >> 癌症
• 参考文献:

  [1]. Wang S, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res. 2014 Oct 15;74(20):5855-5865.

  [2]. Hoffman-Luca CG, et al. Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo. Clin Cancer Res. 2015 Jun 1;21(11):2558-2568.

SAR405838物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 732.1±60.0 °C at 760 mmHg
• 分子式: C₂₉H₃₄Cl₂FN₃O₃
• 分子量: 562.503
• 闪点: 396.6±32.9 °C
• 精确质量: 561.196106
• PSA: 90.46000
• LogP: 5.79
• InChIKey: IDKAKZRYYDCJDU-AEPXTFJPSA-N
• SMILES: CC(C)(C)CC1NC(C(=O)NC2CCC(O)CC2)C(c2cccc(Cl)c2F)C12C(=O)Nc1cc(Cl)ccc12
• 外观性状: 粉末
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.627
• 储存条件: -20℃

SAR405838英文别名

• (2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro [indole-3,3'-pyrrolidine]-5'-carboxylic acid (trans-4-hydroxy-cyclohexyl)-amide
• (2'S,3R,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
• Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2'S,3R,4'S,5'R)-
• SAR405838
• SAR 405838