HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL830248

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 6
First Page: 1683
Last Page: 1686
DOI: 10.1016/j.bmcl.2005.01.049

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
5.4	Ki	=	5400	nM
5340	Ki	=	5340000	nM	Outside typical range
3180	Ki	=	3180000	nM	Outside typical range
9.9	Ki	=	9900	nM
0.079	Ki	=	79	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL828765

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 6
First Page: 1683
Last Page: 1686
DOI: 10.1016/j.bmcl.2005.01.049

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.099	Ki	=	99	nM
1250	Ki	=	1250000	nM	Outside typical range
1080	Ki	=	1080000	nM	Outside typical range
7.8	Ki	=	7800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alkaline phosphatase, tissue-nonspecific isozyme

External ID: CHEMBL640396

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 17
First Page: 3703
Last Page: 3708
DOI: 10.1021/jm030106f

Target ChEMBL ID: CHEMBL2729
ChEMBL Target Name: Alkaline phosphatase tissue-nonspecific
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
NI	Not Active
NI	Not Active
NI	Not Active
NI	Not Active
NI	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3224000

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2012
Volume: 3
Issue: 7
First Page: 735
Last Page: 751
DOI: 10.1039/C2MD20079A

Standard Type	Standard Relation	Standard Value
pKa	=	7.1
pKa	=	7.49
pKa	=	8.4
pKa	=	6.31
pKa	=	7.7

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Protein tyrosine phosphatase receptor type C-associated protein

External ID: CHEMBL812679

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 17
First Page: 3703
Last Page: 3708
DOI: 10.1021/jm030106f

Target ChEMBL ID: CHEMBL4806
ChEMBL Target Name: Protein tyrosine phosphatase receptor type C-associated protein
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	Ki	=	200000	nM	Outside typical range
42000	Ki	=	42000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL769202

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 17
First Page: 3703
Last Page: 3708
DOI: 10.1021/jm030106f

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
220	Ki	=	220000	nM	Outside typical range
200	Ki	=	200000	nM	Outside typical range
210	Ki	=	210000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein phosphatase

External ID: CHEMBL705380

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 17
First Page: 3703
Last Page: 3708
DOI: 10.1021/jm030106f

Target ChEMBL ID: CHEMBL3695
ChEMBL Target Name: Serine/threonine-protein phosphatase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1100	Ki	=	1100000	nM	Outside typical range
130	Ki	=	130000	nM	Outside typical range
170	Ki	=	170000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Free fatty acid receptor 3

External ID: CHEMBL3881355

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Target ChEMBL ID: CHEMBL3886125
ChEMBL Target Name: Free fatty acid receptor 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SureChEMBL Patent Bioactivity Data

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
500	EC50	=	500000	nM		Outside typical range
30	EC50	=	30000	nM
	EC50					Potential missing data
1000	EC50	=	1000000	nM		Outside typical range
3000	EC50	=	3000000	nM		Outside typical range
	EC50				Nd(Toxic)
	EC50					Potential missing data
	EC50				Active
5	EC50	=	5000	nM
	EC50					Potential missing data
	EC50					Potential missing data
	EC50					Potential missing data
	EC50				Active
	EC50					Potential missing data

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alkaline phosphatase, germ cell type

External ID: CHEMBL765525

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 17
First Page: 3703
Last Page: 3708
DOI: 10.1021/jm030106f

Target ChEMBL ID: CHEMBL3402
ChEMBL Target Name: Alkaline phosphatase placental-like
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
19000	Ki	=	19000000	nM	Outside typical range
330	Ki	=	330000	nM	Outside typical range
390	Ki	=	390000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
1550	Ki	=	1550000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL829122

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 6
First Page: 1683
Last Page: 1686
DOI: 10.1016/j.bmcl.2005.01.049

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
2210	Ki	=	2210000	nM	Outside typical range
860	Ki	=	860000	nM	Outside typical range
1230	Ki	=	1230000	nM	Outside typical range
2250	Ki	=	2250000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL841750

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 6
First Page: 1683
Last Page: 1686
DOI: 10.1016/j.bmcl.2005.01.049

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.1	KA	=	0.1	uM
200	KA	=	0.2	mM
500	KA	=	0.5	mM
100	KA	=	0.1	mM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 5A, mitochondrial

External ID: CHEMBL828084

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 6
First Page: 1683
Last Page: 1686
DOI: 10.1016/j.bmcl.2005.01.049

Target ChEMBL ID: CHEMBL4789
ChEMBL Target Name: Carbonic anhydrase VA
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
90	Ki	=	90000	nM
730	Ki	=	730000	nM	Outside typical range
850	Ki	=	850000	nM	Outside typical range
370	Ki	=	370000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL851209

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1993
Volume: 36
Issue: 23
First Page: 3636
Last Page: 3645
DOI: 10.1021/jm00075a019

Standard Type	Standard Relation	Standard Value
pKa	=	4.9
pKa	=	6.6
pKa	=	3.8
pKa	=	11.8
pKa	=	3
pKa	=	5.4
pKa	=	7.6

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3223705

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2012
Volume: 3
Issue: 7
First Page: 735
Last Page: 751
DOI: 10.1039/C2MD20079A

Standard Type	Standard Relation	Standard Value
pKa	=	2.39
pKa	=	1.54
pKa	=	15.6
pKa	=	-1.9
pKa	=	-3.4

993-13-5 靶点实验数据