HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 7

External ID: CHEMBL1960512

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 6
First Page: 2182
Last Page: 2185
DOI: 10.1016/j.bmcl.2012.01.129

Target ChEMBL ID: CHEMBL2326
ChEMBL Target Name: Carbonic anhydrase VII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10.9	Ki	=	10900	nM
5.74	Ki	=	5740	nM
0.27	Ki	=	270	nM
7.76	Ki	=	7760	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL1960519

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 6
First Page: 2182
Last Page: 2185
DOI: 10.1016/j.bmcl.2012.01.129

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	Ki	>	200000	nM	Outside typical range
10.8	Ki	=	10800	nM
0.009	Ki	=	9	nM
200	Ki	>	200000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5384359

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 7
First Page: 5196
Last Page: 5207
DOI: 10.1021/acs.jmedchem.3c00108

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	<	5	%
Inhibition	=	23	%
Inhibition	<	5	%
Inhibition	<	5	%
Inhibition	<	5	%

98-91-9 靶点实验数据