HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4729185

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 17
First Page: 9540
Last Page: 9562
DOI: 10.1021/acs.jmedchem.0c00734

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	>	64	ug.mL-1
Inhibition			%	Not Active
Inhibition			%	Not Active
Inhibition			%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL4672552

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 21.0
First Page: 13064
Last Page: 13075
DOI: 10.1021/acs.jmedchem.0c01390

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0128	Ki	=	12.8	nM
0.0024	Ki	=	2.4	nM
0.0157	Ki	=	15.7	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Endochitinase A1

External ID: CHEMBL1291257

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 23
First Page: 8334
Last Page: 8340
DOI: 10.1016/j.bmc.2010.09.062

Target ChEMBL ID: CHEMBL1293196
ChEMBL Target Name: Chitinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
410	IC50	=	410000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
730	IC50	=	730000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
127	IC50	=	127000	nM	Outside typical range
315	IC50	=	315000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
479	IC50	=	479000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
320	IC50	=	320000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Endochitinase A1

External ID: CHEMBL1291259

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 23
First Page: 8334
Last Page: 8340
DOI: 10.1016/j.bmc.2010.09.062

Target ChEMBL ID: CHEMBL1293196
ChEMBL Target Name: Chitinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Active
Inhibition	=	88	%
Inhibition	=	51	%
Inhibition	=	38	%
Inhibition	=	64	%
Inhibition	=	18	%
Inhibition	=	76	%
Inhibition				Not Active
Inhibition	=	76	%
Inhibition	=	21	%
Inhibition				Not Active
Inhibition	=	25	%
Inhibition	=	60	%
Inhibition				Not Active
Inhibition	=	33	%
Inhibition	=	91	%
Inhibition				Not Active
Inhibition	=	85	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Enterococcus faecium

External ID: CHEMBL4729161

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 17
First Page: 9540
Last Page: 9562
DOI: 10.1021/acs.jmedchem.0c00734

Target ChEMBL ID: CHEMBL357
ChEMBL Target Name: Enterococcus faecium
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	2	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	1	ug.mL-1
MIC	=	1	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	>	64	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL4672549

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 21.0
First Page: 13064
Last Page: 13075
DOI: 10.1021/acs.jmedchem.0c01390

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0668	Ki	=	66.8	nM
0.0751	Ki	=	75.1	nM
0.0628	Ki	=	62.8	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL4672551

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 21.0
First Page: 13064
Last Page: 13075
DOI: 10.1021/acs.jmedchem.0c01390

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
7.8E-4	Ki	=	0.78	nM
4.4E-4	Ki	=	0.44	nM
3.6E-4	Ki	=	0.36	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4729180

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 17
First Page: 9540
Last Page: 9562
DOI: 10.1021/acs.jmedchem.0c00734

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	1	ug.mL-1
Inhibition			%	Active
Inhibition			%	Active
Inhibition			%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL4672550

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 21.0
First Page: 13064
Last Page: 13075
DOI: 10.1021/acs.jmedchem.0c01390

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0027	Ki	=	2.7	nM
5.9E-4	Ki	=	0.59	nM
5.3E-4	Ki	=	0.53	nM

98-75-9 靶点实验数据