HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL3767073

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 5
First Page: 1406
Last Page: 1410
DOI: 10.1016/j.bmcl.2016.01.072

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
310	Ki	=	310000	nM	Outside typical range
0.5	Ki	=	500	nM
31700	Ki	=	31700000	nM	Outside typical range
1.2	Ki	=	1200	nM
63000	Ki	=	63000000	nM	Outside typical range
25800	Ki	=	25800000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
8400	Ki	=	8400000	nM	Outside typical range
200	Ki	=	200000	nM	Outside typical range
18000	Ki	=	18000000	nM	Outside typical range
0.7	Ki	=	700	nM
0.6	Ki	=	600	nM
7000	Ki	=	7000000	nM	Outside typical range
8.7	Ki	=	8700	nM
4000	Ki	=	4000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
300	Ki	=	300000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3767076

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2016
Volume: 26
Issue: 5
First Page: 1406
Last Page: 1410
DOI: 10.1016/j.bmcl.2016.01.072

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
86	Ki	=	86000	nM
54	Ki	=	54000	nM
5700	Ki	=	5700000	nM	Outside typical range
79	Ki	=	79000	nM
20500	Ki	=	20500000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
15100	Ki	=	15100000	nM	Outside typical range
6700	Ki	=	6700000	nM	Outside typical range
5900	Ki	=	5900000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
9100	Ki	=	9100000	nM	Outside typical range
9500	Ki	=	9500000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
7100	Ki	=	7100000	nM	Outside typical range
21300	Ki	=	21300000	nM	Outside typical range
8400	Ki	=	8400000	nM	Outside typical range
7000	Ki	=	7000000	nM	Outside typical range
7400	Ki	=	7400000	nM	Outside typical range
8100	Ki	=	8100000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3767075

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 5
First Page: 1406
Last Page: 1410
DOI: 10.1016/j.bmcl.2016.01.072

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8	Ki	=	8000	nM
33	Ki	=	33000	nM
23	Ki	=	23000	nM
760	Ki	=	760000	nM	Outside typical range
850	Ki	=	850000	nM	Outside typical range
2960	Ki	=	2960000	nM	Outside typical range
4640	Ki	=	4640000	nM	Outside typical range
5130	Ki	=	5130000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
34100	Ki	=	34100000	nM	Outside typical range
820	Ki	=	820000	nM	Outside typical range
68	Ki	=	68000	nM
75	Ki	=	75000	nM
74	Ki	=	74000	nM
670	Ki	=	670000	nM	Outside typical range
88	Ki	=	88000	nM
28000	Ki	=	28000000	nM	Outside typical range
930	Ki	=	930000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range
9730	Ki	=	9730000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3767074

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 5
First Page: 1406
Last Page: 1410
DOI: 10.1016/j.bmcl.2016.01.072

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1130	Ki	=	1130000	nM	Outside typical range
20	Ki	=	20000	nM
49200	Ki	=	49200000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
1600	Ki	=	1600000	nM	Outside typical range
89000	Ki	=	89000000	nM	Outside typical range
30	Ki	=	30000	nM
40	Ki	=	40000	nM
35000	Ki	=	35000000	nM	Outside typical range
8.8	Ki	=	8800	nM
63000	Ki	=	63000000	nM	Outside typical range
200000	Ki	=	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL3815891

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
21	Ki	=	21000	nM
200	Ki	=	200000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
0.5	Ki	=	500	nM
31700	Ki	=	31700000	nM	Outside typical range
1.2	Ki	=	1200	nM
63000	Ki	=	63000000	nM	Outside typical range
25800	Ki	=	25800000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
8400	Ki	=	8400000	nM	Outside typical range
18000	Ki	=	18000000	nM	Outside typical range
0.7	Ki	=	700	nM
0.6	Ki	=	600	nM
7000	Ki	=	7000000	nM	Outside typical range
8.7	Ki	=	8700	nM
4000	Ki	=	4000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL2340378

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1636
Last Page: 1638
DOI: 10.1016/j.bmcl.2013.01.084

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
790	Ki	=	790000	nM	Outside typical range
1.2	Ki	=	1200	nM
118000	Ki	=	118000000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
31700	Ki	=	31700000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
25770	Ki	=	25770000	nM	Outside typical range
107	Ki	=	107000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
8.7	Ki	=	8700	nM
640	Ki	=	640000	nM	Outside typical range
0.7	Ki	=	700	nM
300	Ki	=	300000	nM	Outside typical range
0.5	Ki	=	500	nM
0.6	Ki	=	600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2340377

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1636
Last Page: 1638
DOI: 10.1016/j.bmcl.2013.01.084

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
760	Ki	=	760000	nM	Outside typical range
8.8	Ki	=	8800	nM
950	Ki	=	950000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range
20	Ki	=	20000	nM
40	Ki	=	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2340376

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1636
Last Page: 1638
DOI: 10.1016/j.bmcl.2013.01.084

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
5	Ki	=	5000	nM
830	Ki	=	830000	nM	Outside typical range
720	Ki	=	720000	nM	Outside typical range
73	Ki	=	73000	nM
750	Ki	=	750000	nM	Outside typical range
440	Ki	=	440000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
820	Ki	=	820000	nM	Outside typical range
4080	Ki	=	4080000	nM	Outside typical range
550	Ki	=	550000	nM	Outside typical range
340	Ki	=	340000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
540	Ki	=	540000	nM	Outside typical range
380	Ki	=	380000	nM	Outside typical range
560	Ki	=	560000	nM	Outside typical range
600	Ki	=	600000	nM	Outside typical range
6050	Ki	=	6050000	nM	Outside typical range
760	Ki	=	760000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2342885

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1626
Last Page: 1630
DOI: 10.1016/j.bmcl.2013.01.087

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7.4	Ki	=	7400	nM
800	Ki	=	800000	nM	Outside typical range
650	Ki	=	650000	nM	Outside typical range
72	Ki	=	72000	nM
500	Ki	=	500000	nM	Outside typical range
92	Ki	=	92000	nM
420	Ki	=	420000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
670	Ki	=	670000	nM	Outside typical range
480	Ki	=	480000	nM	Outside typical range
450	Ki	=	450000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
930	Ki	=	930000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
180	Ki	=	180000	nM	Outside typical range
680	Ki	=	680000	nM	Outside typical range
630	Ki	=	630000	nM	Outside typical range
700	Ki	=	700000	nM	Outside typical range
540	Ki	=	540000	nM	Outside typical range
580	Ki	=	580000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 7

External ID: CHEMBL860093

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 12
First Page: 3139
Last Page: 3143
DOI: 10.1016/j.bmcl.2006.03.078

Target ChEMBL ID: CHEMBL2326
ChEMBL Target Name: Carbonic anhydrase VII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
6.8	Ki	=	6800	nM
190	Ki	=	190000	nM	Outside typical range
9200	Ki	=	9200000	nM	Outside typical range
1410	Ki	=	1410000	nM	Outside typical range
12.5	Ki	=	12500	nM
1380	Ki	=	1380000	nM	Outside typical range
270	Ki	=	270000	nM	Outside typical range
160	Ki	=	160000	nM	Outside typical range
1780	Ki	=	1780000	nM	Outside typical range
7300	Ki	=	7300000	nM	Outside typical range
15200	Ki	=	15200000	nM	Outside typical range
1240	Ki	=	1240000	nM	Outside typical range
1060	Ki	=	1060000	nM	Outside typical range
1840	Ki	=	1840000	nM	Outside typical range
1240	Ki	=	1240000	nM	Outside typical range
250	Ki	=	250000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3815894

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
31	Ki	=	31000	nM
820	Ki	=	820000	nM	Outside typical range
8	Ki	=	8000	nM
33	Ki	=	33000	nM
23	Ki	=	23000	nM
760	Ki	=	760000	nM	Outside typical range
850	Ki	=	850000	nM	Outside typical range
2960	Ki	=	2960000	nM	Outside typical range
4640	Ki	=	4640000	nM	Outside typical range
5130	Ki	=	5130000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
34100	Ki	=	34100000	nM	Outside typical range
68	Ki	=	68000	nM
75	Ki	=	75000	nM
74	Ki	=	74000	nM
670	Ki	=	670000	nM	Outside typical range
88	Ki	=	88000	nM
28000	Ki	=	28000000	nM	Outside typical range
930	Ki	=	930000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL839573

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 23
First Page: 5769
Last Page: 5773
DOI: 10.1016/j.bmcl.2004.09.063

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Ki	nM	Not Tested
Ki	nM	Not Tested
Ki	nM	Not Tested
Ki	nM	Not Tested

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2343319

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2013
Volume: 23
Issue: 6
First Page: 1626
Last Page: 1630
DOI: 10.1016/j.bmcl.2013.01.087

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
460	Ki	=	460000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
760	Ki	=	760000	nM	Potential transcription error
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3815893

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
80	Ki	=	80000	nM
4100	Ki	=	4100000	nM	Outside typical range
73	Ki	=	73000	nM
760	Ki	=	760000	nM	Outside typical range
440	Ki	=	440000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
820	Ki	=	820000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
10100	Ki	=	10100000	nM	Outside typical range
930	Ki	=	930000	nM	Outside typical range
990	Ki	=	990000	nM	Outside typical range
600	Ki	=	600000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
810	Ki	=	810000	nM	Outside typical range
380	Ki	=	380000	nM	Outside typical range
2410	Ki	=	2410000	nM	Outside typical range
2700	Ki	=	2700000	nM	Outside typical range
4080	Ki	=	4080000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2343318

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1626
Last Page: 1630
DOI: 10.1016/j.bmcl.2013.01.087

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
570	Ki	=	570000	nM	Outside typical range
8	Ki	=	8000	nM
460	Ki	=	460000	nM	Outside typical range
24500	Ki	=	24500000	nM	Outside typical range
4	Ki	=	4000	nM
660	Ki	=	660000	nM	Outside typical range
6	Ki	=	6000	nM
840	Ki	=	840000	nM	Outside typical range
620	Ki	=	620000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
530	Ki	=	530000	nM	Outside typical range
900	Ki	=	900000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
870	Ki	=	870000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
860	Ki	=	860000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
50900	Ki	=	50900000	nM	Outside typical range
620	Ki	=	620000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3815892

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
390	Ki	=	390000	nM	Outside typical range
1600	Ki	=	1600000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
20	Ki	=	20000	nM
49200	Ki	=	49200000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
89000	Ki	=	89000000	nM	Outside typical range
30	Ki	=	30000	nM
40	Ki	=	40000	nM
35000	Ki	=	35000000	nM	Outside typical range
8.8	Ki	=	8800	nM
63000	Ki	=	63000000	nM	Outside typical range
200000	Ki	=	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3997502

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 6
First Page: 2010
Last Page: 2015
DOI: 10.1016/j.bmc.2017.02.032

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7100	Ki	=	7100000	nM	Outside typical range
320	Ki	=	320000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6500	Ki	=	6500000	nM	Outside typical range
89	Ki	=	89000	nM
3000	Ki	=	3000000	nM	Outside typical range
92	Ki	=	92000	nM
8600	Ki	=	8600000	nM	Outside typical range
8200	Ki	=	8200000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
12700	Ki	=	12700000	nM	Outside typical range
34100	Ki	=	34100000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
3400	Ki	=	3400000	nM	Outside typical range
15600	Ki	=	15600000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
13000	Ki	=	13000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2073325

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 17
First Page: 5630
Last Page: 5634
DOI: 10.1016/j.bmcl.2012.06.106

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
480	Ki	=	480000	nM	Outside typical range
4	Ki	=	4000	nM
490	Ki	=	490000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
9	Ki	=	9000	nM
33200	Ki	=	33200000	nM	Outside typical range
5	Ki	=	5000	nM
39300	Ki	=	39300000	nM	Outside typical range
820	Ki	=	820000	nM	Outside typical range
41700	Ki	=	41700000	nM	Outside typical range
520	Ki	=	520000	nM	Outside typical range
530	Ki	=	530000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
84600	Ki	=	84600000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
60	Ki	=	60000	nM
670	Ki	=	670000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range
860	Ki	=	860000	nM	Outside typical range
790	Ki	=	790000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2073326

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2012
Volume: 22
Issue: 17
First Page: 5630
Last Page: 5634
DOI: 10.1016/j.bmcl.2012.06.106

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
5	Ki	=	5000	nM
830	Ki	=	830000	nM	Outside typical range
720	Ki	=	720000	nM	Outside typical range
73	Ki	=	73000	nM
750	Ki	=	750000	nM	Outside typical range
440	Ki	=	440000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
820	Ki	=	820000	nM	Outside typical range
4080	Ki	=	4080000	nM	Outside typical range
550	Ki	=	550000	nM	Outside typical range
340	Ki	=	340000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
540	Ki	=	540000	nM	Outside typical range
380	Ki	=	380000	nM	Outside typical range
560	Ki	=	560000	nM	Outside typical range
600	Ki	=	600000	nM	Outside typical range
6050	Ki	=	6050000	nM	Outside typical range
760	Ki	=	760000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2406403

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2013
Volume: 23
Issue: 14
First Page: 4067
Last Page: 4071
DOI: 10.1016/j.bmcl.2013.05.063

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
460	Ki	=	460000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
760	Ki	=	760000	nM	Potential transcription error
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4044729

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 17
First Page: 4800
Last Page: 4804
DOI: 10.1016/j.bmc.2017.07.033

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
100000	Ki	>	100000000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9400	Ki	=	9400000	nM	Outside typical range
91	Ki	=	91000	nM
7400	Ki	=	7400000	nM	Outside typical range
90	Ki	=	90000	nM
12800	Ki	=	12800000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
4900	Ki	=	4900000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9300	Ki	=	9300000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9400	Ki	=	9400000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
23500	Ki	=	23500000	nM	Outside typical range
4200	Ki	=	4200000	nM	Outside typical range
19600	Ki	=	19600000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2415219

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2013
Volume: 21
Issue: 15
First Page: 4472
Last Page: 4476
DOI: 10.1016/j.bmc.2013.05.058

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7530	Ki	=	7530000	nM	Outside typical range
19600	Ki	=	19600000	nM	Outside typical range
6340	Ki	=	6340000	nM	Outside typical range
61	Ki	=	61000	nM
8320	Ki	=	8320000	nM	Outside typical range
680	Ki	=	680000	nM	Outside typical range
13500	Ki	=	13500000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9120	Ki	=	9120000	nM	Outside typical range
3160	Ki	=	3160000	nM	Outside typical range
1530	Ki	=	1530000	nM	Outside typical range
8130	Ki	=	8130000	nM	Outside typical range
10300	Ki	=	10300000	nM	Outside typical range
9270	Ki	=	9270000	nM	Outside typical range
9250	Ki	=	9250000	nM	Outside typical range
8920	Ki	=	8920000	nM	Outside typical range
19200	Ki	=	19200000	nM	Outside typical range
23700	Ki	=	23700000	nM	Outside typical range
45900	Ki	=	45900000	nM	Outside typical range
9600	Ki	=	9600000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2415218

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2013
Volume: 21
Issue: 15
First Page: 4472
Last Page: 4476
DOI: 10.1016/j.bmc.2013.05.058

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
9600	Ki	=	9600000	nM	Outside typical range
8360	Ki	=	8360000	nM	Outside typical range
8910	Ki	=	8910000	nM	Outside typical range
97	Ki	=	97000	nM
10400	Ki	=	10400000	nM	Outside typical range
1010	Ki	=	1010000	nM	Outside typical range
9740	Ki	=	9740000	nM	Outside typical range
15100	Ki	=	15100000	nM	Outside typical range
12700	Ki	=	12700000	nM	Outside typical range
1440	Ki	=	1440000	nM	Outside typical range
1370	Ki	=	1370000	nM	Outside typical range
5210	Ki	=	5210000	nM	Outside typical range
2050	Ki	=	2050000	nM	Outside typical range
5720	Ki	=	5720000	nM	Outside typical range
2340	Ki	=	2340000	nM	Outside typical range
4240	Ki	=	4240000	nM	Outside typical range
16500	Ki	=	16500000	nM	Outside typical range
8230	Ki	=	8230000	nM	Outside typical range
20100	Ki	=	20100000	nM	Outside typical range
5590	Ki	=	5590000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma cruzi

External ID: CHEMBL2415217

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2013
Volume: 21
Issue: 15
First Page: 4472
Last Page: 4476
DOI: 10.1016/j.bmc.2013.05.058

Target ChEMBL ID: CHEMBL368
ChEMBL Target Name: Trypanosoma cruzi
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
700	Ki	=	700000	nM	Outside typical range
1120	Ki	=	1120000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
120	Ki	=	120000	nM	Outside typical range
580	Ki	=	580000	nM	Outside typical range
620	Ki	=	620000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
6900	Ki	=	6900000	nM	Outside typical range
900	Ki	=	900000	nM	Outside typical range
720	Ki	=	720000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
760	Ki	=	760000	nM	Outside typical range
650	Ki	=	650000	nM	Outside typical range
780	Ki	=	780000	nM	Outside typical range
93	Ki	=	93000	nM
800	Ki	=	800000	nM	Outside typical range
24300	Ki	=	24300000	nM	Outside typical range
80	Ki	=	80000	nM
44	Ki	=	44000	nM
7100	Ki	=	7100000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL2406401

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 14
First Page: 4067
Last Page: 4071
DOI: 10.1016/j.bmcl.2013.05.063

Target ChEMBL ID: CHEMBL3932
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
6800	Ki	=	6800000	nM		Outside typical range
	Ki				Not Determined
5800	Ki	=	5800000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
42000	Ki	=	42000000	nM		Outside typical range
	Ki				Not Determined
6700	Ki	=	6700000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
160000	Ki	=	160000000	nM		Outside typical range
	Ki				Not Determined
680	Ki	=	680000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2406399

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 14
First Page: 4067
Last Page: 4071
DOI: 10.1016/j.bmcl.2013.05.063

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3100	Ki	=	3100000	nM	Outside typical range
4	Ki	=	4000	nM
73	Ki	=	73000	nM
85500	Ki	=	85500000	nM	Outside typical range
9.2	Ki	=	9200	nM
960	Ki	=	960000	nM	Outside typical range
90	Ki	=	90000	nM
890	Ki	=	890000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
10800	Ki	=	10800000	nM	Outside typical range
16700	Ki	=	16700000	nM	Outside typical range
78900	Ki	=	78900000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
89500	Ki	=	89500000	nM	Outside typical range
18500	Ki	=	18500000	nM	Outside typical range
71600	Ki	=	71600000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
7700	Ki	=	7700000	nM	Outside typical range
41	Ki	=	41000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3815898

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
86	Ki	=	86000	nM
9500	Ki	=	9500000	nM	Outside typical range
54	Ki	=	54000	nM
5700	Ki	=	5700000	nM	Outside typical range
79	Ki	=	79000	nM
20500	Ki	=	20500000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
15100	Ki	=	15100000	nM	Outside typical range
5900	Ki	=	5900000	nM	Outside typical range
6700	Ki	=	6700000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
9100	Ki	=	9100000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
7100	Ki	=	7100000	nM	Outside typical range
21300	Ki	=	21300000	nM	Outside typical range
8400	Ki	=	8400000	nM	Outside typical range
7000	Ki	=	7000000	nM	Outside typical range
7400	Ki	=	7400000	nM	Outside typical range
8100	Ki	=	8100000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL1645694

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 2
First Page: 710
Last Page: 714
DOI: 10.1016/j.bmcl.2010.11.124

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.185	Ki	=	185	nM
0.164	Ki	=	164	nM
0.006	Ki	=	6	nM
23	Ki	=	23000	nM
0.055	Ki	=	55	nM
45.4	Ki	=	45400	nM
9.3	Ki	=	9300	nM
8.6	Ki	=	8600	nM
6	Ki	=	6000	nM
1.2	Ki	=	1200	nM
0.025	Ki	=	25	nM
6.5	Ki	=	6500	nM
8.3	Ki	=	8300	nM
0.05	Ki	=	50	nM
0.25	Ki	=	250	nM
5.8	Ki	=	5800	nM
25	Ki	=	25000	nM
9.8	Ki	=	9800	nM
25	Ki	=	25000	nM
12	Ki	=	12000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3815900

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2016
Volume: 24
Issue: 16
First Page: 3413
Last Page: 3417
DOI: 10.1016/j.bmc.2016.05.029

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
87	Ki	=	87000	nM
13100	Ki	=	13100000	nM	Outside typical range
84	Ki	=	84000	nM
8400	Ki	=	8400000	nM	Outside typical range
91	Ki	=	91000	nM
8700	Ki	=	8700000	nM	Outside typical range
9600	Ki	=	9600000	nM	Outside typical range
7300	Ki	=	7300000	nM	Outside typical range
3000	Ki	=	3000000	nM	Outside typical range
8200	Ki	=	8200000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
2600	Ki	=	2600000	nM	Outside typical range
7900	Ki	=	7900000	nM	Outside typical range
7800	Ki	=	7800000	nM	Outside typical range
8800	Ki	=	8800000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
8800	Ki	=	8800000	nM	Outside typical range
21300	Ki	=	21300000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL4044725

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 17
First Page: 4800
Last Page: 4804
DOI: 10.1016/j.bmc.2017.07.033

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
760	Ki	=	760000	nM	Outside typical range
8.8	Ki	=	8800	nM
200000	Ki	=	200000000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3750045

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 4
First Page: 835
Last Page: 840
DOI: 10.1016/j.bmc.2016.01.005

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8800	Ki	=	8800000	nM	Outside typical range
580	Ki	=	580000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
8300	Ki	=	8300000	nM	Outside typical range
8	Ki	=	8000	nM
1700	Ki	=	1700000	nM	Outside typical range
38	Ki	=	38000	nM
1400	Ki	=	1400000	nM	Outside typical range
9400	Ki	=	9400000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
1800	Ki	=	1800000	nM	Outside typical range
5100	Ki	=	5100000	nM	Outside typical range
7300	Ki	=	7300000	nM	Outside typical range
4500	Ki	=	4500000	nM	Outside typical range
4300	Ki	=	4300000	nM	Outside typical range
5800	Ki	=	5800000	nM	Outside typical range
4700	Ki	=	4700000	nM	Outside typical range
2500	Ki	=	2500000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
4400	Ki	=	4400000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL3595048

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

Target ChEMBL ID: CHEMBL3932
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
6800	Ki	=	6800000	nM		Outside typical range
	Ki				Not Determined
5800	Ki	=	5800000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
42000	Ki	=	42000000	nM		Outside typical range
	Ki				Not Determined
6700	Ki	=	6700000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
90	Ki	=	90000	nM
160000	Ki	=	160000000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4044726

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 17
First Page: 4800
Last Page: 4804
DOI: 10.1016/j.bmc.2017.07.033

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7100	Ki	=	7100000	nM	Outside typical range
320	Ki	=	320000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6500	Ki	=	6500000	nM	Outside typical range
89	Ki	=	89000	nM
3000	Ki	=	3000000	nM	Outside typical range
92	Ki	=	92000	nM
8600	Ki	=	8600000	nM	Outside typical range
8200	Ki	=	8200000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
12700	Ki	=	12700000	nM	Outside typical range
34100	Ki	=	34100000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
3400	Ki	=	3400000	nM	Outside typical range
15600	Ki	=	15600000	nM	Outside typical range
6800	Ki	=	6800000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3595049

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3100	Ki	=	3100000	nM	Outside typical range
4	Ki	=	4000	nM
73	Ki	=	73000	nM
85500	Ki	=	85500000	nM	Outside typical range
9.2	Ki	=	9200	nM
960	Ki	=	960000	nM	Outside typical range
90	Ki	=	90000	nM
890	Ki	=	890000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
10800	Ki	=	10800000	nM	Outside typical range
16700	Ki	=	16700000	nM	Outside typical range
78900	Ki	=	78900000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
910	Ki	=	910000	nM	Outside typical range
97	Ki	=	97000	nM
18500	Ki	=	18500000	nM	Outside typical range
71600	Ki	=	71600000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL2415221

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2013
Volume: 21
Issue: 15
First Page: 4472
Last Page: 4476
DOI: 10.1016/j.bmc.2013.05.058

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8400	Ki	=	8400000	nM	Outside typical range
118000	Ki	=	118000000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
31700	Ki	=	31700000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
990	Ki	=	990000	nM	Outside typical range
110	Ki	=	110000	nM	Outside typical range
85	Ki	=	85000	nM
920	Ki	=	920000	nM	Outside typical range
101	Ki	=	101000	nM	Outside typical range
0.7	Ki	=	700	nM
300	Ki	=	300000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
0.5	Ki	=	500	nM
0.6	Ki	=	600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3595047

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
86	Ki	=	86000	nM
8.8	Ki	=	8800	nM
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2415220

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 15
First Page: 4472
Last Page: 4476
DOI: 10.1016/j.bmc.2013.05.058

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1510	Ki	=	1510000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
200000	Ki	=	200000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range
20	Ki	=	20000	nM
40	Ki	=	40000	nM
89000	Ki	=	89000000	nM	Outside typical range
200	Ki	=	200000	nM	Outside typical range
35000	Ki	=	35000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3595050

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8800	Ki	=	8800000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range
30500	Ki	=	30500000	nM	Outside typical range
8500	Ki	=	8500000	nM	Outside typical range
81	Ki	=	81000	nM
4500	Ki	=	4500000	nM	Outside typical range
84	Ki	=	84000	nM
2400	Ki	=	2400000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
5400	Ki	=	5400000	nM	Outside typical range
7700	Ki	=	7700000	nM	Outside typical range
9100	Ki	=	9100000	nM	Outside typical range
9500	Ki	=	9500000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
8900	Ki	=	8900000	nM	Outside typical range
7600	Ki	=	7600000	nM	Outside typical range
6400	Ki	=	6400000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
8900	Ki	=	8900000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3595051

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
6700	Ki	=	6700000	nM	Outside typical range
960	Ki	=	960000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6100	Ki	=	6100000	nM	Outside typical range
82	Ki	=	82000	nM
6200	Ki	=	6200000	nM	Outside typical range
87	Ki	=	87000	nM
2500	Ki	=	2500000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6700	Ki	=	6700000	nM	Outside typical range
8500	Ki	=	8500000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9100	Ki	=	9100000	nM	Outside typical range
7800	Ki	=	7800000	nM	Outside typical range
34600	Ki	=	34600000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
1700	Ki	=	1700000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1781043

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 12
First Page: 3591
Last Page: 3595
DOI: 10.1016/j.bmcl.2011.04.105

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
970	Ki	=	970000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
86	Ki	=	86000	nM
8.8	Ki	=	8800	nM
950	Ki	=	950000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1781046

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 12
First Page: 3591
Last Page: 3595
DOI: 10.1016/j.bmcl.2011.04.105

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
700	Ki	=	700000	nM	Outside typical range
320	Ki	=	320000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48400	Ki	=	48400000	nM	Outside typical range
8.8	Ki	=	8800	nM
640	Ki	=	640000	nM	Outside typical range
9.1	Ki	=	9100	nM
540	Ki	=	540000	nM	Outside typical range
940	Ki	=	940000	nM	Outside typical range
970	Ki	=	970000	nM	Outside typical range
250	Ki	=	250000	nM	Outside typical range
220	Ki	=	220000	nM	Outside typical range
74900	Ki	=	74900000	nM	Outside typical range
85200	Ki	=	85200000	nM	Outside typical range
640	Ki	=	640000	nM	Outside typical range
890	Ki	=	890000	nM	Outside typical range
69000	Ki	=	69000000	nM	Outside typical range
63400	Ki	=	63400000	nM	Outside typical range
720	Ki	=	720000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL1953640

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2012
Volume: 22
Issue: 3
First Page: 1314
Last Page: 1316
DOI: 10.1016/j.bmcl.2011.12.085

Target ChEMBL ID: CHEMBL1944499
ChEMBL Target Name: Astrosclerin-3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
450	Ki	=	450000	nM	Outside typical range
27800	Ki	=	27800000	nM	Outside typical range
880	Ki	=	880000	nM	Outside typical range
8.9	Ki	=	8900	nM
22800	Ki	=	22800000	nM	Outside typical range
72	Ki	=	72000	nM
13500	Ki	=	13500000	nM	Outside typical range
76300	Ki	=	76300000	nM	Outside typical range
13	Ki	=	13000	nM
940	Ki	=	940000	nM	Outside typical range
670	Ki	=	670000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
88100	Ki	=	88100000	nM	Outside typical range
680	Ki	=	680000	nM	Outside typical range
770	Ki	=	770000	nM	Outside typical range
76700	Ki	=	76700000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
390	Ki	=	390000	nM	Outside typical range
230	Ki	=	230000	nM	Outside typical range
10400	Ki	=	10400000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_8468_4

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	Ki Qualifier	Ki	Ligand	Target
Ki		28000		28000000	BDBM26980	Carbonic anhydrase
Ki		9730		9730000	BDBM26981	Carbonic anhydrase
Ki		33		33000	BDBM26984	Carbonic anhydrase
Ki		76		76000	BDBM26985	Carbonic anhydrase
Ki		5130		5130000	BDBM26986	Carbonic anhydrase
Ki		4640		4640000	BDBM26987	Carbonic anhydrase
Ki		670		670000	BDBM26988	Carbonic anhydrase
Ki		34100		34100000	BDBM26989	Carbonic anhydrase
Ki		74		74000	BDBM26990	Carbonic anhydrase
Ki		68		68000	BDBM26991	Carbonic anhydrase
Ki		850		850000	BDBM26992	Carbonic anhydrase
Ki	>	200000	>	200000000	BDBM26993	Carbonic anhydrase
Ki		31		31000	BDBM26994	Carbonic anhydrase
Ki		8		8000	BDBM26995	Carbonic anhydrase
Ki		7		7000	BDBM26996	Carbonic anhydrase
Ki		23		23000	BDBM26997	Carbonic anhydrase
Ki	>	200000	>	200000000	BDBM36131	Carbonic anhydrase
Ki		43		43000	BDBM50010231	Carbonic anhydrase
Ki		60800		60800000	BDBM50130701	Carbonic anhydrase
Ki		5320		5320000	BDBM50278312	Carbonic anhydrase

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3095734

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 24
First Page: 6706
Last Page: 6710
DOI: 10.1016/j.bmcl.2013.10.037

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
4100	Ki	=	4100000	nM	Outside typical range
360	Ki	=	360000	nM	Outside typical range
4200	Ki	=	4200000	nM	Outside typical range
470	Ki	=	470000	nM	Outside typical range
9	Ki	=	9000	nM
2100	Ki	=	2100000	nM	Outside typical range
7	Ki	=	7000	nM
650	Ki	=	650000	nM	Outside typical range
7900	Ki	=	7900000	nM	Outside typical range
4800	Ki	=	4800000	nM	Outside typical range
1200	Ki	=	1200000	nM	Outside typical range
3300	Ki	=	3300000	nM	Outside typical range
2700	Ki	=	2700000	nM	Outside typical range
9200	Ki	=	9200000	nM	Outside typical range
3600	Ki	=	3600000	nM	Outside typical range
2100	Ki	=	2100000	nM	Outside typical range
2500	Ki	=	2500000	nM	Outside typical range
63400	Ki	=	63400000	nM	Outside typical range
4900	Ki	=	4900000	nM	Outside typical range
1000	Ki	=	1000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_8468_3

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	Ki Qualifier	Ki	Ligand	Target
Ki		2410		2410000	BDBM26980	Alpha-carbonic anhydrase
Ki		6050		6050000	BDBM26981	Alpha-carbonic anhydrase
Ki		760		760000	BDBM26984	Alpha-carbonic anhydrase
Ki		830		830000	BDBM26985	Alpha-carbonic anhydrase
Ki		750		750000	BDBM26986	Alpha-carbonic anhydrase
Ki		660		660000	BDBM26987	Alpha-carbonic anhydrase
Ki		810		810000	BDBM26988	Alpha-carbonic anhydrase
Ki		930		930000	BDBM26989	Alpha-carbonic anhydrase
Ki		690		690000	BDBM26990	Alpha-carbonic anhydrase
Ki		990		990000	BDBM26991	Alpha-carbonic anhydrase
Ki		820		820000	BDBM26992	Alpha-carbonic anhydrase
Ki	>	200000	>	200000000	BDBM26993	Alpha-carbonic anhydrase
Ki		80		80000	BDBM26994	Alpha-carbonic anhydrase
Ki		73		73000	BDBM26995	Alpha-carbonic anhydrase
Ki		97		97000	BDBM26996	Alpha-carbonic anhydrase
Ki		440		440000	BDBM26997	Alpha-carbonic anhydrase
Ki		10100		10100000	BDBM36131	Alpha-carbonic anhydrase
Ki		5		5000	BDBM50010231	Alpha-carbonic anhydrase
Ki		720		720000	BDBM50130701	Alpha-carbonic anhydrase
Ki		550		550000	BDBM50278312	Alpha-carbonic anhydrase

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1781047

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 12
First Page: 3591
Last Page: 3595
DOI: 10.1016/j.bmcl.2011.04.105

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
320	Ki	=	320000	nM	Outside typical range
6.7	Ki	=	6700	nM
750	Ki	=	750000	nM	Outside typical range
72000	Ki	=	72000000	nM	Outside typical range
6.2	Ki	=	6200	nM
27900	Ki	=	27900000	nM	Outside typical range
16.3	Ki	=	16300	nM
6530	Ki	=	6530000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
630	Ki	=	630000	nM	Outside typical range
490	Ki	=	490000	nM	Outside typical range
370	Ki	=	370000	nM	Outside typical range
940	Ki	=	940000	nM	Outside typical range
16200	Ki	=	16200000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
510	Ki	=	510000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
58300	Ki	=	58300000	nM	Outside typical range
310	Ki	=	310000	nM	Outside typical range
640	Ki	=	640000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1645695

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 2
First Page: 710
Last Page: 714
DOI: 10.1016/j.bmcl.2010.11.124

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.05	Ki	=	50	nM
0.046	Ki	=	46	nM
0.002	Ki	=	2	nM
0.133	Ki	=	133	nM
0.08	Ki	=	80	nM
0.295	Ki	=	295	nM
0.019	Ki	=	19	nM
0.06	Ki	=	60	nM
0.07	Ki	=	70	nM
0.038	Ki	=	38	nM
0.008	Ki	=	8	nM
0.04	Ki	=	40	nM
0.06	Ki	=	60	nM
0.014	Ki	=	14	nM
0.012	Ki	=	12	nM
0.063	Ki	=	63	nM
0.17	Ki	=	170	nM
0.11	Ki	=	110	nM
0.24	Ki	=	240	nM
0.04	Ki	=	40	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 6

External ID: CHEMBL1645696

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 2
First Page: 710
Last Page: 714
DOI: 10.1016/j.bmcl.2010.11.124

Target ChEMBL ID: CHEMBL3025
ChEMBL Target Name: Carbonic anhydrase VI
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.024	Ki	=	24	nM
0.055	Ki	=	55	nM
0.073	Ki	=	73	nM
0.887	Ki	=	887	nM
6.68	Ki	=	6680	nM
0.772	Ki	=	772	nM
0.74	Ki	=	740	nM
0.798	Ki	=	798	nM
1.024	Ki	=	1024	nM
0.079	Ki	=	79	nM
0.043	Ki	=	43	nM
4.68	Ki	=	4680	nM
0.096	Ki	=	96	nM
0.01	Ki	=	10	nM
0.011	Ki	=	11	nM
0.955	Ki	=	955	nM
4.8	Ki	=	4800	nM
1.097	Ki	=	1097	nM
0.941	Ki	=	941	nM
8.0E-4	Ki	=	0.8	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL1645697

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2011
Volume: 21
Issue: 2
First Page: 710
Last Page: 714
DOI: 10.1016/j.bmcl.2010.11.124

Target ChEMBL ID: CHEMBL1075028
ChEMBL Target Name: Alpha carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0197	Ki	=	19.7	nM
0.0298	Ki	=	29.8	nM
0.0276	Ki	=	27.6	nM
0.435	Ki	=	435	nM
0.768	Ki	=	768	nM
0.553	Ki	=	553	nM
0.0919	Ki	=	91.9	nM
0.105	Ki	=	105	nM
0.0883	Ki	=	88.3	nM
0.431	Ki	=	431	nM
0.0394	Ki	=	39.4	nM
0.104	Ki	=	104	nM
0.0751	Ki	=	75.1	nM
0.0212	Ki	=	21.2	nM
0.016	Ki	=	16	nM
0.367	Ki	=	367	nM
0.0825	Ki	=	82.5	nM
0.0875	Ki	=	87.5	nM
0.364	Ki	=	364	nM
0.43	Ki	=	430	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3095740

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2013
Volume: 23
Issue: 24
First Page: 6706
Last Page: 6710
DOI: 10.1016/j.bmcl.2013.10.037

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
460	Ki	=	460000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
760	Ki	=	760000	nM	Potential transcription error
20	Ki	=	20000	nM

98-05-5 靶点实验数据