HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania amazonensis

External ID: CHEMBL4825487

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med Chem Lett
Year: 2021
Volume: 12
Issue: 9.0
First Page: 1405
Last Page: 1412
DOI: 10.1021/acsmedchemlett.1c00193

Target ChEMBL ID: CHEMBL612877
ChEMBL Target Name: Leishmania amazonensis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
57.9	IC50	>	57900	nM
	IC50				Not Determined
	IC50				Not Determined
2.76	IC50	=	2760	nM
1.07	IC50	=	1070	nM
3.81	IC50	=	3810	nM
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania infantum

External ID: CHEMBL4825488

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med Chem Lett
Year: 2021
Volume: 12
Issue: 9.0
First Page: 1405
Last Page: 1412
DOI: 10.1021/acsmedchemlett.1c00193

Target ChEMBL ID: CHEMBL612848
ChEMBL Target Name: Leishmania infantum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
25.68	IC50	=	25680	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
0.36	IC50	=	360	nM
0.88	IC50	=	880	nM
3.45	IC50	=	3450	nM
13.26	IC50	=	13260	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 1

External ID: CHEMBL4342201

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 13
First Page: 2753
Last Page: 2763
DOI: 10.1016/j.bmc.2019.05.001

Target ChEMBL ID: CHEMBL5445
ChEMBL Target Name: GABA transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	57	%
Activity	=	48	%
Activity	=	79	%
Activity	=	79	%
Activity	=	79	%
Activity	=	87	%
Activity	=	65	%
Activity	=	81	%
Activity	=	59	%
Activity	=	59	%
Activity	=	85	%
Activity	=	79	%
Activity	=	59	%
Activity	=	20	%
Activity	=	59	%
Activity	=	36	%
Activity	=	65	%
Activity	=	65	%
Activity	=	79	%
Activity	=	55	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Peritoneal macrophage

External ID: CHEMBL4825485

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med Chem Lett
Year: 2021
Volume: 12
Issue: 9.0
First Page: 1405
Last Page: 1412
DOI: 10.1021/acsmedchemlett.1c00193

Target ChEMBL ID: CHEMBL5314330
ChEMBL Target Name: Peritoneal macrophage
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
27.8	CC50	=	27800	nM
	CC50				Not Determined
100	CC50	>	100000	nM
107.8	CC50	=	107800	nM
49.9	CC50	=	49900	nM
24.2	CC50	=	24200	nM
29.8	CC50	=	29800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania amazonensis

External ID: CHEMBL4825486

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med Chem Lett
Year: 2021
Volume: 12
Issue: 9.0
First Page: 1405
Last Page: 1412
DOI: 10.1021/acsmedchemlett.1c00193

Target ChEMBL ID: CHEMBL612877
ChEMBL Target Name: Leishmania amazonensis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
25.2	IC50	=	25200	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
1.99	IC50	=	1990	nM
9.37	IC50	=	9370	nM
9.72	IC50	=	9720	nM
11.32	IC50	=	11320	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta

External ID: CHEMBL1042446

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2009
Volume: 17
Issue: 19
First Page: 6914
Last Page: 6925
DOI: 10.1016/j.bmc.2009.08.042

Target ChEMBL ID: CHEMBL262
ChEMBL Target Name: Glycogen synthase kinase-3 beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
75	IC50	=	75000	nM
8	IC50	=	8000	nM
5	IC50	=	5000	nM
1	IC50	=	1000	nM
0.5	IC50	=	500	nM
10	IC50	=	10000	nM
2.5	IC50	=	2500	nM
1.5	IC50	=	1500	nM
25	IC50	=	25000	nM
2	IC50	=	2000	nM
10	IC50	=	10000	nM
100	IC50	>	100000	nM
50	IC50	=	50000	nM
1	IC50	=	1000	nM
3	IC50	=	3000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
1	IC50	=	1000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Myeloperoxidase

External ID: CHEMBL3877132

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med Chem Lett
Year: 2017
Volume: 8
Issue: 2
First Page: 206
Last Page: 210
DOI: 10.1021/acsmedchemlett.6b00417

Target ChEMBL ID: CHEMBL2439
ChEMBL Target Name: Myeloperoxidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	61	%
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition	=	61	%
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition
Inhibition

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL769352

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1998
Volume: 8
Issue: 19
First Page: 2695
Last Page: 2698
DOI: 10.1016/s0960-894x(98)00468-5

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2	IC50	=	2000	nM
7	IC50	=	7000	nM
0.7	IC50	=	700	nM
10	IC50	=	10000	nM
0.7	IC50	=	700	nM
0.02	IC50	=	20	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Meloidogyne incognita

External ID: CHEMBL3050876

Protocol: N/A

Comment: Journal: J Agric Food Chem
Year: 2012
Volume: 60
Issue: 30
First Page: 7345
Last Page: 7351
DOI: 10.1021/jf302075w

Target ChEMBL ID: CHEMBL613453
ChEMBL Target Name: Meloidogyne incognita
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
mortality	=	100	%
mortality	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Replicase polyprotein 1a

External ID: CHEMBL918640

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2007
Volume: 50
Issue: 8
First Page: 1850
Last Page: 1864
DOI: 10.1021/jm061425k

Target ChEMBL ID: CHEMBL3927
ChEMBL Target Name: SARS coronavirus 3C-like proteinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	<	10	%
Inhibition	=	23	%
Inhibition	=	36	%
Inhibition	=	39	%
Inhibition	=	70	%
Inhibition	<	10	%
Inhibition	=	13	%
Inhibition	<	10	%
Inhibition	<	10	%
Inhibition	<	10	%
Inhibition	=	20	%
Inhibition	=	99	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Meloidogyne incognita

External ID: CHEMBL3051195

Protocol: N/A

Comment: Journal: J Agric Food Chem
Year: 2012
Volume: 60
Issue: 30
First Page: 7345
Last Page: 7351
DOI: 10.1021/jf302075w

Target ChEMBL ID: CHEMBL613453
ChEMBL Target Name: Meloidogyne incognita
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
EC50	>	10	ug.mL-1
EC50	=	3.6	ug.mL-1
EC50	>	250	ug.mL-1	Outside typical range
EC50	=	68.9	ug.mL-1	Outside typical range
EC50	=	14.08	ug.mL-1
EC50	>	250	ug.mL-1	Outside typical range
EC50	=	301	ug.mL-1	Outside typical range
EC50	=	8.5	ug.mL-1
EC50	=	7.86	ug.mL-1
EC50	>	250	ug.mL-1	Outside typical range
EC50	>	250	ug.mL-1	Outside typical range
EC50	>	100	ug.mL-1	Outside typical range
EC50	=	392	ug.mL-1	Outside typical range
EC50	>	1000	ug.mL-1	Outside typical range
EC50	=	0.4	ug.mL-1
EC50	=	1.13	ug.mL-1
EC50	>	250	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Meloidogyne incognita

External ID: CHEMBL3051196

Protocol: N/A

Comment: Journal: J Agric Food Chem
Year: 2012
Volume: 60
Issue: 30
First Page: 7345
Last Page: 7351
DOI: 10.1021/jf302075w

Target ChEMBL ID: CHEMBL613453
ChEMBL Target Name: Meloidogyne incognita
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
EC50	>	250	ug.mL-1	Outside typical range
EC50	=	25	ug.mL-1
EC50	>	250	ug.mL-1	Outside typical range
EC50	>	250	ug.mL-1	Outside typical range
EC50	=	105	ug.mL-1	Outside typical range
EC50	>	250	ug.mL-1	Outside typical range
EC50	>	250	ug.mL-1	Outside typical range
EC50	=	11.4	ug.mL-1
EC50	>	10	ug.mL-1
EC50	>	250	ug.mL-1	Outside typical range
EC50	>	250	ug.mL-1	Outside typical range
EC50	>	100	ug.mL-1	Outside typical range
EC50	>	1000	ug.mL-1	Outside typical range
EC50	>	1000	ug.mL-1	Outside typical range
EC50	=	3.3	ug.mL-1
EC50	=	1.2	ug.mL-1
EC50	>	250	ug.mL-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 1

External ID: CHEMBL4371733

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2018
Volume: 61
Issue: 22
First Page: 10310
Last Page: 10332
DOI: 10.1021/acs.jmedchem.8b01602

Target ChEMBL ID: CHEMBL5445
ChEMBL Target Name: GABA transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	109	%
Activity	=	118	%
Activity	=	111	%
Activity	=	98	%
Activity	=	113	%
Activity	=	107	%
Activity	=	75	%
Activity	=	99	%
Activity	=	108	%
Activity	=	77	%
Activity	=	72	%
Activity	=	114	%
Activity	=	127	%
Activity	=	97	%
Activity	=	98	%
Activity	=	107	%
Activity	=	88	%
Activity	=	100	%
Activity	=	112	%
Activity	=	108	%

98-03-3 靶点实验数据