HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Putative nitroreductase

External ID: CHEMBL4380255

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL4523956
ChEMBL Target Name: Putative nitroreductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Text Value
Drug metabolism	Metabolite_Detected

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Putative nitroreductase

External ID: CHEMBL4380225

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL4523956
ChEMBL Target Name: Putative nitroreductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Retention_time	=	19.38	min
Retention_time	=	16.85	min
Retention_time	=	20.13	min
Retention_time	=	24.21	min
Retention_time	=	18.56	min
Retention_time	=	18.41	min
Retention_time	=	25.98	min
Retention_time	=	17.72	min
Retention_time	=	17.94	min
Retention_time	=	17.57	min
Retention_time	=	17.74	min
Retention_time	=	20.58	min
Retention_time	=	15.1	min
Retention_time	=	23.17	min
Retention_time	=	16.92	min

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PC-3

External ID: CHEMBL4380257

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL390
ChEMBL Target Name: PC-3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
5.07	IC50	=	5070	nM
0.0018	IC50	=	1.8	nM
150	IC50	>	150000	nM	Outside typical range
150	IC50	>	150000	nM	Outside typical range
5.73	IC50	=	5730	nM
9.77	IC50	=	9770	nM
7.83	IC50	=	7830	nM
9.58	IC50	=	9580	nM
150	IC50	=	150000	nM	Outside typical range
150	IC50	>	150000	nM	Outside typical range
6.43	IC50	=	6430	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hep 3B2

External ID: CHEMBL4380259

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL4296437
ChEMBL Target Name: Hep 3B2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	=	51	%
Activity	=	51	%
Activity	>	80	%
Activity	>	80	%
Activity	=	51	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	=	51	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hep 3B2

External ID: CHEMBL4380260

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL4296437
ChEMBL Target Name: Hep 3B2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	=	51	%
Activity	>	80	%
Activity	=	51	%
Activity	>	80	%
Activity	>	80	%
Activity	=	51	%
Activity	=	51	%
Activity	=	51	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	=	51	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PC-3

External ID: CHEMBL4380261

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL390
ChEMBL Target Name: PC-3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	=	51	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	=	51	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PC-3

External ID: CHEMBL4380262

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL390
ChEMBL Target Name: PC-3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HUVEC

External ID: CHEMBL4380263

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL613979
ChEMBL Target Name: HUVEC
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HUVEC

External ID: CHEMBL4380264

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL613979
ChEMBL Target Name: HUVEC
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	=	51	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%
Activity	>	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Putative nitroreductase

External ID: CHEMBL4380265

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL4523956
ChEMBL Target Name: Putative nitroreductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Not Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PC-3

External ID: CHEMBL4380266

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2020
Volume: 187
First Page: 111937
Last Page: 111937
DOI: 10.1016/j.ejmech.2019.111937

Target ChEMBL ID: CHEMBL390
ChEMBL Target Name: PC-3
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

970-76-3 靶点实验数据