HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aurora kinase A

External ID: CHEMBL5067447

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4722
ChEMBL Target Name: Serine/threonine-protein kinase Aurora-A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	0.05675	C	Thermal Shift Assay
Delta TM	=	0.06056	C	Thermal Shift Assay
Delta TM	=	-0.26	C
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	0.2158	C	Thermal Shift Assay
Delta TM	=	0.1132	C	Thermal Shift Assay
Delta TM	=	-0.21	C	Thermal Shift Assay
Delta TM	=	0.07973	C	Thermal Shift Assay
Delta TM	=	0.3724	C	Thermal Shift Assay
Delta TM	=	-0.3	C
Delta TM	=	-0.04	C	Thermal Shift Assay
Delta TM	=	-0.08	C	Thermal Shift Assay
Delta TM	=	-0.49	C	Thermal Shift Assay
Delta TM	=	0.08515	C	Thermal Shift Assay
Delta TM	=	0.01057	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	0.1944	C	Thermal Shift Assay
Delta TM	=	2.51	C	Thermal Shift Assay
Delta TM	=	-0.01	C	Thermal Shift Assay
Delta TM	=	-0.24	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Fibroblast

External ID: CHEMBL4725213

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5314315
ChEMBL Target Name: Fibroblast
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value
Growth Rate	=	-0.32
Growth Rate	=	-0.85
Growth Rate	=	0.66
Growth Rate	=	0.58
Growth Rate	=	0.86
Growth Rate	=	0.06
Growth Rate	=	0.1
Growth Rate	=	0.63
Growth Rate	=	0.67
Growth Rate	=	0.46
Growth Rate	=	0.87
Growth Rate	=	0
Growth Rate	=	0.46
Growth Rate	=	0.87
Growth Rate	=	-0.42
Growth Rate	=	-0.57
Growth Rate	=	-0.81
Growth Rate	=	0.2
Growth Rate	=	0.77
Growth Rate	=	0.4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HEK-293T

External ID: CHEMBL4725212

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3706568
ChEMBL Target Name: HEK-293T
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value
Growth Rate	=	0.66
Growth Rate	=	0.47
Growth Rate	=	0.81
Growth Rate	=	0.62
Growth Rate	=	0.92
Growth Rate	=	0.99
Growth Rate	=	-0.15
Growth Rate	=	-0.01
Growth Rate	=	0.69
Growth Rate	=	0.27
Growth Rate	=	0.71
Growth Rate	=	0.38
Growth Rate	=	0.78
Growth Rate	=	0.46
Growth Rate	=	0.9
Growth Rate	=	0.97
Growth Rate	=	0.97
Growth Rate	=	0.5
Growth Rate	=	0.33
Growth Rate	=	0.54

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：U2OS

External ID: CHEMBL4725214

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL615023
ChEMBL Target Name: U2OS
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value
Growth Rate	=	0.94
Growth Rate	=	0.96
Growth Rate	=	0.56
Growth Rate	=	0.78
Growth Rate	=	0.8
Growth Rate	=	0.92
Growth Rate	=	0.78
Growth Rate	=	-0.28
Growth Rate	=	-0.1
Growth Rate	=	0.54
Growth Rate	=	0.58
Growth Rate	=	0.72
Growth Rate	=	0.97
Growth Rate	=	0.76
Growth Rate	=	0.97
Growth Rate	=	0.82
Growth Rate	=	0.75
Growth Rate	=	0.87
Growth Rate	=	0.77
Growth Rate	=	0.78

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：IUPHAR-DB 靶标：inhibitor of nuclear factor kappa B kinase subunit beta (IKK family) [Homo sapiens]

External ID: 2039_Human

Protocol: The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY Database (GtoPdb) uses expert subcommittees to collate peer-reviewed information from the published literature regarding individual protein targets, and describes the pharmacology, genetics, function and anatomy of each target. Its pages provide a richly curated overview of the pharmacology of receptors, ion channels, enzymes and other target types, which can be found by following the external link to the GtoPdb website.

Comment: The data collected focuses on ligands at human receptors. Data are provided at rat or mouse orthologues where there are significant species differences, or where data are not yet available at the human target.

Information on individual experimental protocols can be found in the primary references listed for each ligand.

Affinity data are expressed as pKi [-log(Ki)], pKd [-log(Kd)], pIC50 [-log(IC50)], pEC50 [-log(EC50)], pKB [-log(KB)], pA2 or as a micromolar concentration range. In most cases the original concentration can be found in the primary reference.

pKi_min	pKi_max	pKd_min	pKd_max	pIC50_min	pIC50_max	Type	Action	Reference (PubMed ID)
				7.6	7.6	Inhibitor	Inhibition
5.6	5.6					Inhibitor	Inhibition	28737909
		6.9	6.9	6.5	6.5	Allosteric modulator	Negative	22037378,12403772
				7.4	7.4	Inhibitor	Inhibition	19168710

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2

External ID: CHEMBL4513082

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0.24	%
Inhibition	=	4.58	%
Inhibition	=	-0.3	%
Inhibition	=	-0.3	%
Inhibition	=	-0.04	%
Inhibition	=	-0.04	%
Inhibition	=	-0.08	%
Inhibition	=	-0.08	%
Inhibition	=	-0.08	%
Inhibition	=	-0.08	%
Inhibition	=	0.03	%
Inhibition	=	0	%
Inhibition	=	0.03	%
Inhibition	=	0	%
Inhibition	=	-0.27	%
Inhibition	=	-0.27	%
Inhibition	=	-0.08	%
Inhibition	=	-0.08	%
Inhibition	=	14.41	%
Inhibition	=	0.39	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mitogen-activated protein kinase 1

External ID: CHEMBL5066518

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4040
ChEMBL Target Name: MAP kinase ERK2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	-0.03532	C	Thermal Shift Assay
Delta TM	=	-0.09791	C	Thermal Shift Assay
Delta TM	=	-0.72	C
Delta TM	=	0.39	C	Thermal Shift Assay
Delta TM	=	0.6544	C	Thermal Shift Assay
Delta TM	=	0.01068	C	Thermal Shift Assay
Delta TM	=	0.05	C	Thermal Shift Assay
Delta TM	=	0.3911	C	Thermal Shift Assay
Delta TM	=	-0.1368	C	Thermal Shift Assay
Delta TM	=	0.38	C
Delta TM	=	0.18	C	Thermal Shift Assay
Delta TM	=	0.02	C	Thermal Shift Assay
Delta TM	=	0.24	C	Thermal Shift Assay
Delta TM	=	-0.1886	C	Thermal Shift Assay
Delta TM	=	-0.3286	C	Thermal Shift Assay
Delta TM	=	-0.9406	C	Thermal Shift Assay
Delta TM	=	-0.6238	C	Thermal Shift Assay
Delta TM	=	0.17	C	Thermal Shift Assay
Delta TM	=	0.35	C	Thermal Shift Assay
Delta TM	=	0.08	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepatocyte spheroids

External ID: CHEMBL5608110

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705882
ChEMBL Target Name: Hepatocyte spheroids
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Cell Viability	=	103.77	%	Non-Toxic
Cell Viability	=	109.96	%	Non-Toxic
Cell Viability	=	116.91	%	Non-Toxic
Cell Viability	=	121.21	%	Non-Toxic
Cell Viability	=	97.07	%	Non-Toxic
Cell Viability	=	98.74	%	Non-Toxic
Cell Viability	=	0.6826	%	Toxic
Cell Viability	=	106.67	%	Non-Toxic
Cell Viability	=	110.72	%	Non-Toxic
Cell Viability	=	101.03	%	Non-Toxic
Cell Viability	=	76.08	%	Non-Toxic
Cell Viability	=	77.79	%	Non-Toxic
Cell Viability	=	3.579	%	Toxic
Cell Viability	=	111.82	%	Non-Toxic
Cell Viability	=	87.12	%	Non-Toxic
Cell Viability	=	81.56	%	Non-Toxic
Cell Viability	=	55.65	%	Toxic
Cell Viability	=	107.95	%	Non-Toxic
Cell Viability	=	106.14	%	Non-Toxic
Cell Viability	=	158.22	%	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5608114

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Cell Viability	=	96.4	%
Cell Viability	=	106.68	%
Cell Viability	=	85.68	%
Cell Viability	=	87.44	%
Cell Viability	=	89.07	%
Cell Viability	=	72.02	%
Cell Viability	=	80.19	%
Cell Viability	=	113.81	%
Cell Viability	=	117.04	%
Cell Viability	=	3.966	%
Cell Viability	=	34.51	%
Cell Viability	=	118.75	%
Cell Viability	=	127.31	%
Cell Viability	=	9.694	%
Cell Viability	=	16.25	%
Cell Viability	=	88.56	%
Cell Viability	=	104.25	%
Cell Viability	=	73.69	%
Cell Viability	=	82.53	%
Cell Viability	=	105.74	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5608115

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Cell Viability	=	27.37	%
Cell Viability	=	3.121	%
Cell Viability	=	23.6	%
Cell Viability	=	48.12	%
Cell Viability	=	60.25	%
Cell Viability	=	3.876	%
Cell Viability	=	7.3	%
Cell Viability	=	43.44	%
Cell Viability	=	64.98	%
Cell Viability	=	32.83	%
Cell Viability	=	23.75	%
Cell Viability	=	47.7	%
Cell Viability	=	22.11	%
Cell Viability	=	37.73	%
Cell Viability	=	17.88	%
Cell Viability	=	36.96	%
Cell Viability	=	37.56	%
Cell Viability	=	44.8	%
Cell Viability	=	59.34	%
Cell Viability	=	62.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5608116

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Cell Viability	=	111.7	%
Cell Viability	=	53.28	%
Cell Viability	=	209.92	%
Cell Viability	=	108.75	%
Cell Viability	=	105.54	%
Cell Viability	=	62.09	%
Cell Viability	=	32.9	%
Cell Viability	=	79.72	%
Cell Viability	=	135.66	%
Cell Viability	=	130.07	%
Cell Viability	=	56.06	%
Cell Viability	=	99.69	%
Cell Viability	=	62.91	%
Cell Viability	=	113.51	%
Cell Viability	=	44.8	%
Cell Viability	=	118.17	%
Cell Viability	=	154.42	%
Cell Viability	=	168.3	%
Cell Viability	=	147.9	%
Cell Viability	=	124.45	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5608117

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Cell Viability	=	48.13	%
Cell Viability	=	19.48	%
Cell Viability	=	263.44	%
Cell Viability	=	58.3	%
Cell Viability	=	47.8	%
Cell Viability	=	19.24	%
Cell Viability	=	13.71	%
Cell Viability	=	46.3	%
Cell Viability	=	93.49	%
Cell Viability	=	60.6	%
Cell Viability	=	53.97	%
Cell Viability	=	52.03	%
Cell Viability	=	27.61	%
Cell Viability	=	54.6	%
Cell Viability	=	24.3	%
Cell Viability	=	64.28	%
Cell Viability	=	69.7	%
Cell Viability	=	82	%
Cell Viability	=	77.1	%
Cell Viability	=	52.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5608118

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Cell Viability	=	50.04	%
Cell Viability	=	23.63	%
Cell Viability	=	131.49	%
Cell Viability	=	81.51	%
Cell Viability	=	77.11	%
Cell Viability	=	28.28	%
Cell Viability	=	46.57	%
Cell Viability	=	76.16	%
Cell Viability	=	82.61	%
Cell Viability	=	64.44	%
Cell Viability	=	56.85	%
Cell Viability	=	68.11	%
Cell Viability	=	48.38	%
Cell Viability	=	105.35	%
Cell Viability	=	39.83	%
Cell Viability	=	71.94	%
Cell Viability	=	100.33	%
Cell Viability	=	124.43	%
Cell Viability	=	83.76	%
Cell Viability	=	77.44	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5608142

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Cell Viability	=	93.23	%
Cell Viability	=	112.2	%
Cell Viability	=	65.66	%
Cell Viability	=	92.7	%
Cell Viability	=	38.3	%
Cell Viability	=	73.84	%
Cell Viability	=	90.44	%
Cell Viability	=	135.53	%
Cell Viability	=	16.89	%
Cell Viability	=	39.68	%
Cell Viability	=	29.55	%
Cell Viability	=	143.54	%
Cell Viability	=	8.004	%
Cell Viability	=	640.05	%
Cell Viability	=	72.66	%
Cell Viability	=	141.04	%
Cell Viability	=	149.52	%
Cell Viability	=	281.87	%
Cell Viability	=	97.86	%
Cell Viability	=	73.49	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5608143

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Cell Viability	=	121.26	%
Cell Viability	=	106.18	%
Cell Viability	=	80.11	%
Cell Viability	=	85.92	%
Cell Viability	=	35.76	%
Cell Viability	=	62.59	%
Cell Viability	=	116.82	%
Cell Viability	=	125.79	%
Cell Viability	=	38.74	%
Cell Viability	=	28.79	%
Cell Viability	=	7.425	%
Cell Viability	=	53.43	%
Cell Viability	=	24.85	%
Cell Viability	=	220.95	%
Cell Viability	=	155.5	%
Cell Viability	=	107.03	%
Cell Viability	=	96.23	%
Cell Viability	=	101.21	%
Cell Viability	=	52.02	%
Cell Viability	=	58.54	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5608144

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units
Cell Viability	=	126.18	%
Cell Viability	=	75.39	%
Cell Viability	=	54.6	%
Cell Viability	=	78.61	%
Cell Viability	=	44.15	%
Cell Viability	=	195.34	%
Cell Viability	=	105.96	%
Cell Viability	=	101.96	%
Cell Viability	=	50.69	%
Cell Viability	=	47.12	%
Cell Viability	=	11.09	%
Cell Viability	=	189.71	%
Cell Viability	=	13.99	%
Cell Viability	=	352.85	%
Cell Viability	=	105.88	%
Cell Viability	=	98.61	%
Cell Viability	=	106.26	%
Cell Viability	=	101.74	%
Cell Viability	=	91.69	%
Cell Viability	=	97.56	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Angiotensin-converting enzyme

External ID: CHEMBL4887178

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4074
ChEMBL Target Name: Angiotensin-converting enzyme
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	98	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Natriuretic peptides A

External ID: CHEMBL4887177

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3097985
ChEMBL Target Name: Natriuretic peptides A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-2A adrenergic receptor

External ID: CHEMBL4887176

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2093864
ChEMBL Target Name: Adrenergic receptor alpha-2
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	103	%	Not Active
% Ctrl	=	102	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Alpha-1A adrenergic receptor

External ID: CHEMBL4887175

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1907610
ChEMBL Target Name: Adrenergic receptor alpha-1
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	109	%	Not Active
% Ctrl	=	93	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15

External ID: CHEMBL4887166

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4358
ChEMBL Target Name: Arachidonate 15-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	79	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX12

External ID: CHEMBL4887165

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3687
ChEMBL Target Name: Arachidonate 12-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	96	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B

External ID: CHEMBL4887168

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2093870
ChEMBL Target Name: Serotonin 2 (5-HT2) receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	97	%	Not Active
% Ctrl	=	95	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1F

External ID: CHEMBL4887167

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2095159
ChEMBL Target Name: Serotonin 1 (5-HT1) receptor
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	119	%	Not Active
% Ctrl	=	107	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta

External ID: CHEMBL5065589

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL262
ChEMBL Target Name: Glycogen synthase kinase-3 beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Delta TM	=	5.443	C	Thermal Shift Assay
Delta TM	=	-0.3085	C	Thermal Shift Assay
Delta TM	=	-0.7	C
Delta TM	=	-0.03	C	Thermal Shift Assay
Delta TM	=	11.17	C	Thermal Shift Assay
Delta TM	=	-1.553	C	Thermal Shift Assay
Delta TM	=	-0.29	C	Thermal Shift Assay
Delta TM	=	-0.3615	C	Thermal Shift Assay
Delta TM	=	0.0664	C	Thermal Shift Assay
Delta TM	=	-0.66	C
Delta TM	=	-0.06	C	Thermal Shift Assay
Delta TM	=	-0.21	C	Thermal Shift Assay
Delta TM	=	-0.26	C	Thermal Shift Assay
Delta TM	=	-1.145	C	Thermal Shift Assay
Delta TM	=	-0.6697	C	Thermal Shift Assay
Delta TM	=	0	C	Thermal Shift Assay
Delta TM	=	-0.4876	C	Thermal Shift Assay
Delta TM	=	2.74	C	Thermal Shift Assay
Delta TM	=	0.22	C	Thermal Shift Assay
Delta TM	=	-0.06	C	Thermal Shift Assay

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：3-hydroxy-3-methylglutaryl-coenzyme A reductase

External ID: CHEMBL4887206

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3247
ChEMBL Target Name: HMG-CoA reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	85	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：ATP-sensitive inward rectifier potassium channel 1 isoform X1

External ID: CHEMBL4887209

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4524026
ChEMBL Target Name: ATP-sensitive inward rectifier potassium channel 1 isoform X1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	110	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase, inducible

External ID: CHEMBL4887207

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3464
ChEMBL Target Name: Nitric oxide synthase, inducible
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	108	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL4887195

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase 3

External ID: CHEMBL4887201

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4802
ChEMBL Target Name: Nitric-oxide synthase, endothelial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	100	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Neutrophil elastase

External ID: CHEMBL4887200

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL248
ChEMBL Target Name: Leukocyte elastase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	98	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Chymase

External ID: CHEMBL4887190

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4068
ChEMBL Target Name: Chymase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	93	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calcitonin gene-related peptide type 1 receptor

External ID: CHEMBL4887189

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2107838
ChEMBL Target Name: Calcitonin-gene-related peptide receptor, CALCRL/RAMP1
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	99	%	Not Active
% Ctrl	=	96	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(1A) dopamine receptor

External ID: CHEMBL4887194

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2056
ChEMBL Target Name: Dopamine D1 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	101	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 2

External ID: CHEMBL4887193

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL230
ChEMBL Target Name: Cyclooxygenase-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	82	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 1

External ID: CHEMBL4887192

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL221
ChEMBL Target Name: Cyclooxygenase-1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	105	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase 3

External ID: CHEMBL4887191

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1075230
ChEMBL Target Name: Nitric oxide synthase, endothelial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	102	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5724559

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Cell Viability	=	146.93	%	Luminescence
Cell Viability	=	92.42	%	Luminescence
Cell Viability	=	137.32	%	Object Area
Cell Viability	=	95.84	%	Object Area
Cell Viability	=	30.1	%	Luminescence
Cell Viability	=	45.18	%	Luminescence
Cell Viability	=	84.35	%	Object Area
Cell Viability	=	67.45	%	Object Area
Cell Viability	=	3.322	%	Luminescence
Cell Viability	=	3.495	%	Luminescence
Cell Viability	=	9.147	%	Object Area
Cell Viability	=	11.54	%	Object Area
Cell Viability	=	79.36	%	Luminescence
Cell Viability	=	89.56	%	Luminescence
Cell Viability	=	109.07	%	Object Area
Cell Viability	=	103.32	%	Object Area
Cell Viability	=	2.387	%	Luminescence
Cell Viability	=	3.908	%	Luminescence
Cell Viability	=	8.346	%	Object Area
Cell Viability	=	9.337	%	Object Area

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5724561

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Cell Viability	=	110.58	%	Luminescence
Cell Viability	=	91.32	%	Luminescence
Cell Viability	=	96.41	%	Object Area
Cell Viability	=	86.99	%	Object Area
Cell Viability	=	121.35	%	Luminescence
Cell Viability	=	105.02	%	Luminescence
Cell Viability	=	98.38	%	Object Area
Cell Viability	=	111.73	%	Object Area
Cell Viability	=	107.52	%	Luminescence
Cell Viability	=	104.61	%	Luminescence
Cell Viability	=	121.53	%	Object Area
Cell Viability	=	94.42	%	Object Area
Cell Viability	=	89.19	%	Luminescence
Cell Viability	=	98.57	%	Luminescence
Cell Viability	=	86.74	%	Object Area
Cell Viability	=	117.35	%	Object Area
Cell Viability	=	123.06	%	Luminescence
Cell Viability	=	81.11	%	Luminescence
Cell Viability	=	103.62	%	Object Area
Cell Viability	=	93.88	%	Object Area

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Colon cancer organoid

External ID: CHEMBL5724560

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5705881
ChEMBL Target Name: Colon cancer organoid
ChEMBL Target Type: 3D CELL CULTURE - Target is a 3D cell culture model such as an organoid, sphereoid or tumoroid that mimics tissues or organs
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: EUbOPEN Chemogenomic Library

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Cell Viability	=	133.3	%	Luminescence
Cell Viability	=	129.12	%	Luminescence
Cell Viability	=	96.49	%	Object Area
Cell Viability	=	84.49	%	Object Area
Cell Viability	=	88.97	%	Luminescence
Cell Viability	=	82.19	%	Luminescence
Cell Viability	=	63.58	%	Object Area
Cell Viability	=	57.5	%	Object Area
Cell Viability	=	15.16	%	Luminescence
Cell Viability	=	27.56	%	Luminescence
Cell Viability	=	31.67	%	Object Area
Cell Viability	=	31.58	%	Object Area
Cell Viability	=	80.49	%	Luminescence
Cell Viability	=	55.99	%	Luminescence
Cell Viability	=	115.36	%	Object Area
Cell Viability	=	103.89	%	Object Area
Cell Viability	=	14.26	%	Luminescence
Cell Viability	=	12.85	%	Luminescence
Cell Viability	=	15.33	%	Object Area
Cell Viability	=	14.47	%	Object Area

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1C

External ID: CHEMBL4887186

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3762
ChEMBL Target Name: Voltage-gated L-type calcium channel alpha-1C subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	99	%	Not Active
% Ctrl	=	70	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent N-type calcium channel subunit alpha-1B

External ID: CHEMBL4887185

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5107
ChEMBL Target Name: Voltage-gated N-type calcium channel alpha-1B subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	86	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1C

External ID: CHEMBL4887184

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3762
ChEMBL Target Name: Voltage-gated L-type calcium channel alpha-1C subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	87	%	Not Active
% Ctrl	=	101	%	Not Active
% Ctrl	=	111	%	Not Active
% Ctrl	=	99	%	Not Active
% Ctrl	=	45	%	Slightly Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent L-type calcium channel subunit alpha-1C

External ID: CHEMBL4887183

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3762
ChEMBL Target Name: Voltage-gated L-type calcium channel alpha-1C subunit
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	77	%	Not Active
% Ctrl	=	91	%	Not Active
% Ctrl	=	94	%	Not Active
% Ctrl	=	104	%	Not Active
% Ctrl	=	41.5	%	Slightly Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-2

External ID: CHEMBL4887238

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4106158
ChEMBL Target Name: AMP-activated protein kinase alpha-2/beta-2/gamma-2
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	88	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-2

External ID: CHEMBL4887237

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3038456
ChEMBL Target Name: AMPK alpha2/beta2/gamma1
ChEMBL Target Type: PROTEIN COMPLEX - Target is a defined protein complex, consisting of multiple subunits
Relationship Type: D - Direct protein target assigned
Confidence: Direct protein complex subunits assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	88	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bone morphogenetic protein receptor type-2

External ID: CHEMBL4887242

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5467
ChEMBL Target Name: Bone morphogenetic protein receptor type-2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	65	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ankyrin repeat and protein kinase domain-containing protein 1

External ID: CHEMBL4887240

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5547
ChEMBL Target Name: Ankyrin repeat and protein kinase domain-containing protein 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	95	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Activin receptor type-1-like

External ID: CHEMBL4887229

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5311
ChEMBL Target Name: Serine/threonine-protein kinase receptor R3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	64	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Activin receptor type-2A

External ID: CHEMBL4887228

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL5616
ChEMBL Target Name: Activin receptor type-2A
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SGC Frankfurt - Donated Chemical Probes

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
% Ctrl	=	108	%	Not Active

960293-88-3 靶点实验数据