HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL667494

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 8
First Page: 1476
Last Page: 1482
DOI: 10.1021/jm00158a026

Target ChEMBL ID: CHEMBL339
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1	IC50	>	1000	nM
1	IC50	>	1000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL616273

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 7
First Page: 1709
Last Page: 1712
DOI: 10.1016/j.bmcl.2004.01.045

Target ChEMBL ID: CHEMBL214
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.114	IC50	=	114	nM
0.046	IC50	=	46	nM
0.93	IC50	=	930	nM
0.004	IC50	=	4	nM
0.012	IC50	=	12	nM
1	IC50	>	1000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL841450

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1988
Volume: 31
Issue: 10
First Page: 1968
Last Page: 1971
DOI: 10.1021/jm00118a018

Target ChEMBL ID: CHEMBL273
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value
Hill coefficient	=	0.95
Hill coefficient	=	0.83
Hill coefficient	=	0.95
Hill coefficient	=	0.97
Hill coefficient	=	0.85
Hill coefficient	=	1.02
Hill coefficient	=	0.97
Hill coefficient	=	1.03
Hill coefficient	=	0.99
Hill coefficient	=	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL786832

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 8
First Page: 1476
Last Page: 1482
DOI: 10.1021/jm00158a026

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MED	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL616344

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1996
Volume: 39
Issue: 1
First Page: 126
Last Page: 134
DOI: 10.1021/jm950410b

Target ChEMBL ID: CHEMBL273
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	Ki	=	10000	nM
0.16982	Ki	=	169.82	nM
2.51189	Ki	=	2511.89	nM
0.01072	Ki	=	10.72	nM
0.004786	Ki	=	4.786	nM
0.01995	Ki	=	19.95	nM
0.001862	Ki	=	1.862	nM
6.026E-4	Ki	=	0.6026	nM
0.39811	Ki	=	398.11	nM
0.14454	Ki	=	144.54	nM
0.01288	Ki	=	12.88	nM
0.6166	Ki	=	616.6	nM
0.02188	Ki	=	21.88	nM
1.0E-4	Ki	=	0.1	nM
0.00263	Ki	=	2.63	nM
0.02512	Ki	=	25.12	nM
0.07943	Ki	=	79.43	nM
0.002399	Ki	=	2.399	nM
0.09333	Ki	=	93.33	nM
50.1187	Ki	=	50118.72	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL780685

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 8
First Page: 1476
Last Page: 1482
DOI: 10.1021/jm00158a026

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	65	mg.kg-1
ED50	=	53	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL618371

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 7
First Page: 1709
Last Page: 1712
DOI: 10.1016/j.bmcl.2004.01.045

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	0.07667	hr
T1/2	=	0.4467	hr
T1/2	=	0.085	hr
T1/2	=	0.505	hr
T1/2	=	1.305	hr
T1/2	=	0.8717	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL780686

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 8
First Page: 1476
Last Page: 1482
DOI: 10.1021/jm00158a026

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	20	mg.kg-1
ED50	=	3.6	mg.kg-1
ED50	=	6.5	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A

External ID: CHEMBL615962

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1988
Volume: 31
Issue: 10
First Page: 1968
Last Page: 1971
DOI: 10.1021/jm00118a018

Target ChEMBL ID: CHEMBL273
ChEMBL Target Name: Serotonin 1a (5-HT1a) receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.068	Ki	=	68	nM
0.38	Ki	=	380	nM
2.9	Ki	=	2900	nM
1.52	Ki	=	1520	nM
0.036	Ki	=	36	nM
0.01	Ki	=	10	nM
0.06	Ki	=	60	nM
0.002	Ki	=	2	nM
6	Ki	>	6000	nM
0.001	Ki	=	1	nM
1.41	Ki	=	1410	nM

95604-92-5 靶点实验数据