HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cholinesterase

External ID: CHEMBL2401047

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 14
First Page: 4218
Last Page: 4224
DOI: 10.1016/j.bmc.2013.05.001

Target ChEMBL ID: CHEMBL1914
ChEMBL Target Name: Butyrylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
2.26	IC50	=	2260	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PC-12

External ID: CHEMBL2401046

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 14
First Page: 4218
Last Page: 4224
DOI: 10.1016/j.bmc.2013.05.001

Target ChEMBL ID: CHEMBL612556
ChEMBL Target Name: PC-12
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic
Activity	Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Short transient receptor potential channel 4

External ID: CHEMBL4377055

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 17
First Page: 7589
Last Page: 7602
DOI: 10.1021/acs.jmedchem.8b01954

Target ChEMBL ID: CHEMBL1741219
ChEMBL Target Name: Short transient receptor potential channel 4
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10.3	IC50	=	10300	nM
5.2	IC50	=	5200	nM
5.5	IC50	=	5500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2401045

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 14
First Page: 4218
Last Page: 4224
DOI: 10.1016/j.bmc.2013.05.001

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	37.7
Ratio IC50	=	43.8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Short transient receptor potential channel 5

External ID: CHEMBL4377056

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 17
First Page: 7589
Last Page: 7602
DOI: 10.1021/acs.jmedchem.8b01954

Target ChEMBL ID: CHEMBL4523481
ChEMBL Target Name: Short transient receptor potential channel 5
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
8.2	IC50	=	8200	nM
6.6	IC50	=	6600	nM
8	IC50	=	8000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL2401044

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 14
First Page: 4218
Last Page: 4224
DOI: 10.1016/j.bmc.2013.05.001

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Non-toxic
Activity				Non-toxic
Activity				Non-toxic
Activity	=	85.2	%
Activity				Non-toxic
Activity				Non-toxic
Activity				Non-toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Short transient receptor potential channel 6

External ID: CHEMBL4377057

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 17
First Page: 7589
Last Page: 7602
DOI: 10.1021/acs.jmedchem.8b01954

Target ChEMBL ID: CHEMBL1795081
ChEMBL Target Name: Short transient receptor potential channel 6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
59.6	IC50	=	59600	nM
63.8	IC50	=	63800	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Short transient receptor potential channel 3

External ID: CHEMBL4377058

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2019
Volume: 62
Issue: 17
First Page: 7589
Last Page: 7602
DOI: 10.1021/acs.jmedchem.8b01954

Target ChEMBL ID: CHEMBL2417348
ChEMBL Target Name: Short transient receptor potential channel 3
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
48.6	IC50	=	48600	nM
19.3	IC50	=	19300	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Acetylcholinesterase

External ID: CHEMBL2401048

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 14
First Page: 4218
Last Page: 4224
DOI: 10.1016/j.bmc.2013.05.001

Target ChEMBL ID: CHEMBL220
ChEMBL Target Name: Acetylcholinesterase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
59.68	IC50	=	59680	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM

953071-75-5 靶点实验数据