HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL3761623

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 5
First Page: 982
Last Page: 988
DOI: 10.1016/j.bmc.2016.01.020

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	Ki	>	50000	nM
0.421	Ki	=	421	nM
0.02	Ki	=	20	nM
0.0219	Ki	=	21.9	nM
0.0215	Ki	=	21.5	nM
0.428	Ki	=	428	nM
0.458	Ki	=	458	nM
0.442	Ki	=	442	nM
0.0423	Ki	=	42.3	nM
0.0425	Ki	=	42.5	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3761627

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 5
First Page: 982
Last Page: 988
DOI: 10.1016/j.bmc.2016.01.020

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	10
Ratio Ki	=	12.79
Ratio Ki	>	56.63
Ratio Ki	=	10.14
Ratio Ki	>	110.13
Ratio Ki	=	9.091
Ratio Ki	=	0.45
Ratio Ki	=	1.78
Ratio Ki	>	1388.89
Ratio Ki	=	12.42
Ratio Ki	=	9.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 12

External ID: CHEMBL3761626

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 5
First Page: 982
Last Page: 988
DOI: 10.1016/j.bmc.2016.01.020

Target ChEMBL ID: CHEMBL3242
ChEMBL Target Name: Carbonic anhydrase XII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0112	Ki	=	11.2	nM
0.0088	Ki	=	8.8	nM
0.0198	Ki	=	19.8	nM
0.427	Ki	=	427	nM
50	Ki	>	50000	nM
0.0103	Ki	=	10.3	nM
0.0104	Ki	=	10.4	nM
0.0075	Ki	=	7.5	nM
0.0319	Ki	=	31.9	nM
0.213	Ki	=	213	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL3761625

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 5
First Page: 982
Last Page: 988
DOI: 10.1016/j.bmc.2016.01.020

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.883	Ki	=	883	nM
0.0415	Ki	=	41.5	nM
0.0022	Ki	=	2.2	nM
0.0022	Ki	=	2.2	nM
0.0024	Ki	=	2.4	nM
0.952	Ki	=	952	nM
0.257	Ki	=	257	nM
0.0356	Ki	=	35.6	nM
0.0023	Ki	=	2.3	nM
0.0026	Ki	=	2.6	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3761624

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 5
First Page: 982
Last Page: 988
DOI: 10.1016/j.bmc.2016.01.020

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.464	Ki	=	464	nM
0.328	Ki	=	328	nM
0.0017	Ki	=	1.7	nM
0.0018	Ki	=	1.8	nM
0.0019	Ki	=	1.9	nM
0.258	Ki	=	258	nM
0.248	Ki	=	248	nM
0.29	Ki	=	290	nM
0.0021	Ki	=	2.1	nM
0.0034	Ki	=	3.4	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL923357

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 16
First Page: 4708
Last Page: 4714
DOI: 10.1016/j.bmcl.2006.12.065

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.25	ug ml-1
Activity	=	5	ug ml-1
Activity	=	8	ug ml-1
Activity	=	4	ug ml-1
Activity	=	2	ug ml-1
Activity	=	63	ug ml-1
Activity	=	16	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3761630

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 5
First Page: 982
Last Page: 988
DOI: 10.1016/j.bmc.2016.01.020

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	2
Ratio Ki	=	0.124
Ratio Ki	=	41.43
Ratio Ki	=	37.27
Ratio Ki	=	26.04
Ratio Ki	=	0.086
Ratio Ki	=	25.04
Ratio Ki	=	23.85
Ratio Ki	>	5154.64
Ratio Ki	=	38.67
Ratio Ki	=	0.017

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3761629

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 5
First Page: 982
Last Page: 988
DOI: 10.1016/j.bmc.2016.01.020

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	41.67
Ratio Ki	=	1.462
Ratio Ki	>	4464.29
Ratio Ki	=	47.84
Ratio Ki	>	4504.5
Ratio Ki	=	1.01
Ratio Ki	=	41.57
Ratio Ki	=	44.04
Ratio Ki	>	5154.64
Ratio Ki	=	58.93
Ratio Ki	=	0.151

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3761628

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2016
Volume: 24
Issue: 5
First Page: 982
Last Page: 988
DOI: 10.1016/j.bmc.2016.01.020

Standard Type	Standard Relation	Standard Value
Ratio Ki	=	0.48
Ratio Ki	=	1.083
Ratio Ki	=	0.53
Ratio Ki	=	7.9
Ratio Ki	=	0.64
Ratio Ki	=	0.773
Ratio Ki	=	0.27
Ratio Ki	=	0.96
Ratio Ki	>	1388.89
Ratio Ki	=	8.15
Ratio Ki	=	1.045

950642-45-2 靶点实验数据