HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cell division cycle 7-related protein kinase

External ID: CHEMBL944978

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 3
First Page: 487
Last Page: 501
DOI: 10.1021/jm700956r

Target ChEMBL ID: CHEMBL5443
ChEMBL Target Name: Cell division cycle 7-related protein kinase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.009	IC50	=	9	nM
0.007	IC50	=	7	nM
0.178	IC50	=	178	nM
0.002	IC50	=	2	nM
0.404	IC50	=	404	nM
0.027	IC50	=	27	nM
0.158	IC50	=	158	nM
0.088	IC50	=	88	nM
0.008	IC50	=	8	nM
0.005	IC50	=	5	nM
0.012	IC50	=	12	nM
0.042	IC50	=	42	nM
0.023	IC50	=	23	nM
0.013	IC50	=	13	nM
0.004	IC50	=	4	nM
0.003	IC50	=	3	nM
0.047	IC50	=	47	nM
5	IC50	>	5000	nM
0.12	IC50	=	120	nM
0.259	IC50	=	259	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase N1

External ID: CHEMBL5134828

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2022
Volume: 60
First Page: 128588
Last Page: 128588
DOI: 10.1016/j.bmcl.2022.128588

Target ChEMBL ID: CHEMBL3384
ChEMBL Target Name: Protein kinase N1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.5	IC50	=	4500	nM
3	IC50	=	3000	nM
5	IC50	>	5000	nM
0.52	IC50	=	520	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5134829

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2022
Volume: 60
First Page: 128588
Last Page: 128588
DOI: 10.1016/j.bmcl.2022.128588

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	18.8
Ratio IC50	=	16.9
Ratio IC50	=	13.5
Ratio IC50	=	14.7

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase N2

External ID: CHEMBL5134825

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2022
Volume: 60
First Page: 128588
Last Page: 128588
DOI: 10.1016/j.bmcl.2022.128588

Target ChEMBL ID: CHEMBL3032
ChEMBL Target Name: Protein kinase N2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.13	Ki	=	130	nM
0.32	Ki	=	320	nM
1.3	Ki	=	1300	nM
0.025	Ki	=	25	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase N2

External ID: CHEMBL5134826

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2022
Volume: 60
First Page: 128588
Last Page: 128588
DOI: 10.1016/j.bmcl.2022.128588

Target ChEMBL ID: CHEMBL3032
ChEMBL Target Name: Protein kinase N2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.26	IC50	=	260	nM
0.64	IC50	=	640	nM
2.6	IC50	=	2600	nM
0.05	IC50	=	50	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase N1

External ID: CHEMBL5134827

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2022
Volume: 60
First Page: 128588
Last Page: 128588
DOI: 10.1016/j.bmcl.2022.128588

Target ChEMBL ID: CHEMBL3384
ChEMBL Target Name: Protein kinase N1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
2.2	Ki	=	2200	nM
1.5	Ki	=	1500	nM
	Ki				ND
0.26	Ki	=	260	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_3056_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50		0.009		9	O00311,Q9UBU7	BDBM27382	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.178		178	O00311,Q9UBU7	BDBM27385	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.004		4	O00311,Q9UBU7	BDBM27390	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.002		2	O00311,Q9UBU7	BDBM27391	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.404		404	O00311,Q9UBU7	BDBM27394	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.027		27	O00311,Q9UBU7	BDBM27397	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.158		158	O00311,Q9UBU7	BDBM27398	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.088		88	O00311,Q9UBU7	BDBM27403	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.008		8	O00311,Q9UBU7	BDBM27404	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.005		5	O00311,Q9UBU7	BDBM27406	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.012		12	O00311,Q9UBU7	BDBM27407	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.042		42	O00311,Q9UBU7	BDBM27408	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.023		23	O00311,Q9UBU7	BDBM27410	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.013		13	O00311,Q9UBU7	BDBM27411	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.004		4	O00311,Q9UBU7	BDBM27412	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.003		3	O00311,Q9UBU7	BDBM27413	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.047		47	O00311,Q9UBU7	BDBM27414	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50	>	5	>	5000	O00311,Q9UBU7	BDBM27415	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.12		120	O00311,Q9UBU7	BDBM27418	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A
IC50		0.259		259	O00311,Q9UBU7	BDBM27419	Cell division cycle 7-related protein kinase [58-574]/Protein DBF4 homolog A

942425-31-2 靶点实验数据