HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL4406526

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 10
First Page: 5526
Last Page: 5567
DOI: 10.1021/acs.jmedchem.0c00424

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	EC50				Not Active
50	EC50	>	50000	nM
4.4	EC50	=	4400	nM
	EC50				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL4406527

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 10
First Page: 5526
Last Page: 5567
DOI: 10.1021/acs.jmedchem.0c00424

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
10	IC50	>	10000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
1.2	IC50	=	1200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_11220_2

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	EC50 Qualifier	EC50	Target Accession(s)	Ligand	Target
EC50		0.217		217	P14416	BDBM50527973	D(2) dopamine receptor
EC50		2.3		2300	P14416	BDBM50527974	D(2) dopamine receptor
EC50	>	50	>	50000	P14416	BDBM50527977	D(2) dopamine receptor

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_11220_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	EC50 Qualifier	EC50	Target Accession(s)	Ligand	Target
EC50		0.0338		33.8	P35462	BDBM50527974	D(3) dopamine receptor
EC50		0.126		126	P35462	BDBM50527977	D(3) dopamine receptor

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(3) dopamine receptor

External ID: CHEMBL4406531

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 10
First Page: 5526
Last Page: 5567
DOI: 10.1021/acs.jmedchem.0c00424

Target ChEMBL ID: CHEMBL234
ChEMBL Target Name: Dopamine D3 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Emax	=	103	%
Emax	=	35	%
Emax	=	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL4406532

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 10
First Page: 5526
Last Page: 5567
DOI: 10.1021/acs.jmedchem.0c00424

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Emax				Not Determined
Emax				Not Active
Emax				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(2) dopamine receptor

External ID: CHEMBL4406533

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 10
First Page: 5526
Last Page: 5567
DOI: 10.1021/acs.jmedchem.0c00424

Target ChEMBL ID: CHEMBL217
ChEMBL Target Name: Dopamine D2 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Imax				Not Determined
Imax				Not Active
Imax	=	111	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：D(3) dopamine receptor

External ID: CHEMBL4406524

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2020
Volume: 63
Issue: 10
First Page: 5526
Last Page: 5567
DOI: 10.1021/acs.jmedchem.0c00424

Target ChEMBL ID: CHEMBL234
ChEMBL Target Name: Dopamine D3 receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.71	EC50	=	710	nM
0.115	EC50	=	115	nM
1	EC50	=	1000	nM
0.611	EC50	=	611	nM
1.9	EC50	=	1900	nM
	EC50				Not Active

930893-33-7 靶点实验数据