HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta

External ID: CHEMBL920549

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 23
First Page: 7103
Last Page: 7112
DOI: 10.1021/jm040895g

Target ChEMBL ID: CHEMBL2095188
ChEMBL Target Name: Glycogen synthase kinase-3
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2	IC50	=	2000	nM
5	IC50	=	5000	nM
10	IC50	=	10000	nM
5	IC50	=	5000	nM
1	IC50	=	1000	nM
3	IC50	=	3000	nM
2.5	IC50	=	2500	nM
2	IC50	=	2000	nM
3	IC50	=	3000	nM
3	IC50	=	3000	nM
3	IC50	=	3000	nM
12	IC50	=	12000	nM
100	IC50	>	100000	nM
50	IC50	>	50000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	=	100000	nM
100	IC50	=	100000	nM
100	IC50	=	100000	nM
100	IC50	=	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3283074

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1976
Volume: 19
Issue: 3
First Page: 433
Last Page: 436
DOI: 10.1021/jm00225a022

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_987_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50		3		3000	G1T8E2	BDBM7805	Glycogen synthase kinase-3 beta [7-25]
IC50		2.5		2500	G1T8E2	BDBM7806	Glycogen synthase kinase-3 beta [7-25]
IC50		2		2000	G1T8E2	BDBM7807	Glycogen synthase kinase-3 beta [7-25]
IC50		3		3000	G1T8E2	BDBM7808	Glycogen synthase kinase-3 beta [7-25]
IC50		3		3000	G1T8E2	BDBM7809	Glycogen synthase kinase-3 beta [7-25]
IC50		3		3000	G1T8E2	BDBM7810	Glycogen synthase kinase-3 beta [7-25]
IC50		12		12000	G1T8E2	BDBM7811	Glycogen synthase kinase-3 beta [7-25]
IC50	>	100	>	100000	G1T8E2	BDBM7812	Glycogen synthase kinase-3 beta [7-25]
IC50	>	100	>	100000	G1T8E2	BDBM7814	Glycogen synthase kinase-3 beta [7-25]
IC50	>	100	>	100000	G1T8E2	BDBM7815	Glycogen synthase kinase-3 beta [7-25]
IC50	>	100	>	100000	G1T8E2	BDBM7816	Glycogen synthase kinase-3 beta [7-25]
IC50	>	100	>	100000	G1T8E2	BDBM7817	Glycogen synthase kinase-3 beta [7-25]
IC50		100		100000	G1T8E2	BDBM7818	Glycogen synthase kinase-3 beta [7-25]
IC50		100		100000	G1T8E2	BDBM7819	Glycogen synthase kinase-3 beta [7-25]
IC50		100		100000	G1T8E2	BDBM7820	Glycogen synthase kinase-3 beta [7-25]
IC50		100		100000	G1T8E2	BDBM7821	Glycogen synthase kinase-3 beta [7-25]
IC50		50		50000	G1T8E2	BDBM7825	Glycogen synthase kinase-3 beta [7-25]
IC50		100		100000	G1T8E2	BDBM7834	Glycogen synthase kinase-3 beta [7-25]
IC50		100		100000	G1T8E2	BDBM7835	Glycogen synthase kinase-3 beta [7-25]
IC50		100		100000	G1T8E2	BDBM7836	Glycogen synthase kinase-3 beta [7-25]

930-60-9 靶点实验数据