HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL3396596

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 3
First Page: 632
Last Page: 647
DOI: 10.1016/j.bmc.2014.11.025

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC				Not Determined
MIC	=	100	ug.mL-1
MIC	=	25	ug.mL-1
MIC	=	25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL642395

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2000
Volume: 43
Issue: 22
First Page: 4328
Last Page: 4331
DOI: 10.1021/jm000921k

Standard Type	Standard Relation	Standard Value	Standard Units
k	=	6.48E-4	hr-1
k	=	2.3	hr-1
k	=	0.00103	hr-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL638937

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2000
Volume: 43
Issue: 22
First Page: 4328
Last Page: 4331
DOI: 10.1021/jm000921k

Standard Type	Standard Relation	Standard Value	Standard Units
k2	=	3.21	M-1 s-1
k2	=	3.32	M-1 s-1
k2	=	1.21	M-1 s-1
k2	=	5.59	M-1 s-1
k2	=	1.36	M-1 s-1
k2	=	2.72	M-1 s-1
k2	=	2.37	M-1 s-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Moraxella catarrhalis

External ID: CHEMBL3396594

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 3
First Page: 632
Last Page: 647
DOI: 10.1016/j.bmc.2014.11.025

Target ChEMBL ID: CHEMBL614429
ChEMBL Target Name: Moraxella catarrhalis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC				Not Determined
MIC	=	200	ug.mL-1
MIC	=	50	ug.mL-1
MIC	=	6.25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Protein cereblon

External ID: CHEMBL5340015

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2023
Volume: 66
Issue: 5
First Page: 3173
Last Page: 3194
DOI: 10.1021/acs.jmedchem.2c01882

Target ChEMBL ID: CHEMBL3763008
ChEMBL Target Name: Protein cereblon
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.3	Ki	=	4300	nM
43	Ki	=	43000	nM
77	Ki	=	77000	nM
88	Ki	=	88000	nM
28	Ki	=	28000	nM
522	Ki	=	522000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Moraxella catarrhalis

External ID: CHEMBL3396595

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2015
Volume: 23
Issue: 3
First Page: 632
Last Page: 647
DOI: 10.1016/j.bmc.2014.11.025

Target ChEMBL ID: CHEMBL614429
ChEMBL Target Name: Moraxella catarrhalis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MBC				Not Determined
MBC	>	200	ug ml-1
MBC	=	50	ug ml-1
MBC	=	6.25	ug ml-1

930-21-2 靶点实验数据