HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis variant bovis

External ID: CHEMBL745314

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 4
First Page: 1008
Last Page: 1017
DOI: 10.1021/jm0303453

Target ChEMBL ID: CHEMBL613086
ChEMBL Target Name: Mycobacterium tuberculosis variant bovis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	<	1	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1819925

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 18
First Page: 5585
Last Page: 5595
DOI: 10.1016/j.bmc.2011.07.034

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium avium

External ID: CHEMBL987021

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2008
Volume: 43
Issue: 2
First Page: 381
Last Page: 392
DOI: 10.1016/j.ejmech.2007.04.010

Target ChEMBL ID: CHEMBL614982
ChEMBL Target Name: Mycobacterium avium
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus anthracis

External ID: CHEMBL1819924

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 18
First Page: 5585
Last Page: 5595
DOI: 10.1016/j.bmc.2011.07.034

Target ChEMBL ID: CHEMBL613904
ChEMBL Target Name: Bacillus anthracis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL987020

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2008
Volume: 43
Issue: 2
First Page: 381
Last Page: 392
DOI: 10.1016/j.ejmech.2007.04.010

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1819927

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2011
Volume: 19
Issue: 18
First Page: 5585
Last Page: 5595
DOI: 10.1016/j.bmc.2011.07.034

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1819926

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 18
First Page: 5585
Last Page: 5595
DOI: 10.1016/j.bmc.2011.07.034

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL914572

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 3
First Page: 1055
Last Page: 1063
DOI: 10.1128/aac.01063-06

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	1	ug.mL-1
MIC	=	5	ug.mL-1
MIC	=	2.5	ug.mL-1
MIC	=	2.5	ug.mL-1
MIC	=	25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL909164

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 18
First Page: 4743
Last Page: 4747
DOI: 10.1016/j.bmcl.2006.06.095

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC99	=	2	ug ml-1
MIC99				Not Determined
MIC99				Not Determined
MIC99				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycolicibacterium aurum

External ID: CHEMBL987022

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2008
Volume: 43
Issue: 2
First Page: 381
Last Page: 392
DOI: 10.1016/j.ejmech.2007.04.010

Target ChEMBL ID: CHEMBL612952
ChEMBL Target Name: Mycolicibacterium aurum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	2	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Klebsiella pneumoniae

External ID: CHEMBL1819929

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 18
First Page: 5585
Last Page: 5595
DOI: 10.1016/j.bmc.2011.07.034

Target ChEMBL ID: CHEMBL350
ChEMBL Target Name: Klebsiella pneumoniae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pseudomonas aeruginosa

External ID: CHEMBL1819928

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 18
First Page: 5585
Last Page: 5595
DOI: 10.1016/j.bmc.2011.07.034

Target ChEMBL ID: CHEMBL348
ChEMBL Target Name: Pseudomonas aeruginosa
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1819931

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 18
First Page: 5585
Last Page: 5595
DOI: 10.1016/j.bmc.2011.07.034

Standard Type	Standard Relation	Standard Value
Selectivity Index	>	16.5
Selectivity Index	>	16.5
Selectivity Index	>	16.5
Selectivity Index	>	16.5
Selectivity Index	>	16.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL987019

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2008
Volume: 43
Issue: 2
First Page: 381
Last Page: 392
DOI: 10.1016/j.ejmech.2007.04.010

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	2.5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycolicibacterium smegmatis

External ID: CHEMBL1819930

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2011
Volume: 19
Issue: 18
First Page: 5585
Last Page: 5595
DOI: 10.1016/j.bmc.2011.07.034

Target ChEMBL ID: CHEMBL613088
ChEMBL Target Name: Mycolicibacterium smegmatis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	200	ug.mL-1
MIC	>	200	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL914577

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 3
First Page: 1055
Last Page: 1063
DOI: 10.1128/aac.01063-06

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis variant bovis BCG

External ID: CHEMBL914578

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 3
First Page: 1055
Last Page: 1063
DOI: 10.1128/aac.01063-06

Target ChEMBL ID: CHEMBL615052
ChEMBL Target Name: Mycobacterium tuberculosis variant bovis BCG
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.25	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL914579

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 3
First Page: 1055
Last Page: 1063
DOI: 10.1128/aac.01063-06

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.25	ug.mL-1
MIC	=	10	ug.mL-1
MIC	=	2.5	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	75	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL914580

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 3
First Page: 1055
Last Page: 1063
DOI: 10.1128/aac.01063-06

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.1	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	10	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL914573

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 3
First Page: 1055
Last Page: 1063
DOI: 10.1128/aac.01063-06

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.5	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL909165

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2006
Volume: 16
Issue: 18
First Page: 4743
Last Page: 4747
DOI: 10.1016/j.bmcl.2006.06.095

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC99	=	1.1	ug ml-1
MIC99	=	0.5	ug ml-1
MIC99	=	0.075	ug ml-1
MIC99	=	0.5	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL909166

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2006
Volume: 16
Issue: 18
First Page: 4743
Last Page: 4747
DOI: 10.1016/j.bmcl.2006.06.095

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition	=	61.02	%
Inhibition	=	94.25	%
Inhibition				Not Active
Inhibition	=	53.32	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL914575

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 3
First Page: 1055
Last Page: 1063
DOI: 10.1128/aac.01063-06

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Vero

External ID: CHEMBL909167

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 18
First Page: 4743
Last Page: 4747
DOI: 10.1016/j.bmcl.2006.06.095

Target ChEMBL ID: CHEMBL391
ChEMBL Target Name: Vero
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Activity Comment
Selectivity index	=	82
Selectivity index			Not Determined
Selectivity index			Not Determined
Selectivity index			Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A

External ID: HMS1482

Protocol: Prior to screening, cells were passaged in high glucose DMEM supplemented with 10% FBS, 1% P/S, 1 mM pyruvate, and HEPES. Media was changed every 1-2 days to prevent starvation and maintain cellular health.

On the day of screening, 384-well plates (Corning 3765) were filled with 30 uL of control cybrid cell suspension (33.3 cells/ul). Media for resuspension was DMEM supplemented with 10% FBS, 1% P/S, 1 mM pyruvate, and HEPES. Positive control columns were 23 and 24 for most plate setups. Initially, tunicamycin (15 nM) and galactose media (10 mM + 1 mM glucosamine) were used in columns 23 and 24, respectively. Over the course of the screen, galactose was substituted with Vidofludimus (11 uM). Next, 33 nL of each compound were pin-transferred to each plate in duplicate. Final assay well volume was 30 uL. Plates were stacked 2 high, covered with lids, and incubated at 37 degrees C for 2 days.

After 2 days of incubation, Hoescht (10 ul/well) was added to assay plates and fluorescence was read using the Acumen laser scanning cytometer. After, the bottom of plates were sealed with two layers of Brightmax Sealing Films. Then Promega NanoGlo Live cell reagent (20 ul/well) was added to each well and luminescence was read on a PerkinElmer EnVision plate reader after 5 minute of shaking.

Comment: Data analysis method and criteria for scoring active compounds:

Normalized luminescence values (luminescence / cell number) for each replicate were calculated (based on average of 2 luminescence reads per replicate). Z-scores were calculated using the plate average and standard deviation of experimental well normalized values. Each plate replicate was individually analyzed to measure reproducibility across plates. Z-scores were then averaged across replicates and a Z-score threshold of 1.96 was selected for positive hits, indicating increased mitochondrial supercomplex formation. Wells were excluded from further consideration based on low cell number (1 or both replicates with number of objects count < 1500). Activity scores were determined by scaling Z-scores from 0 (activity score = 0) to 4 (activity score = 100), with activity score > 50 being considered active. Z-scores < 0 were set to activity score = 0; Z-scores > 4 were set to activity score = 100 (100% activity).

Luminescence_R1_A	Luminescence_R2_A	Hoechst_NumObjects_A	Luminescence_R1_B	Luminescence_R2_B	Hoechst_NumObjects_B	AvgLumin_A	Ratio_A	AvgLumin_B	Ratio_B	Hoescht_Avg	Ratio_Z score	Comment	Molar Concentration
300583	296601	4427	396274	381039	4754	298592	67.4479	388656	81.7536	4590.5	-0.509481		2 mM
306398	301530	3313	363462	354883	3423	303964	91.7489	359172	104.929	3368	0.282407		10 mM
322997	324293	4706	384126	370237	4185	323645	68.7728	377182	90.127	4445.5	-0.349379		2 mM
281487	277179	4410	298737	291541	4419	279333	63.3408	295139	66.7886	4414.5	-0.825012		10 mM
331940	327309	5409	320983	313490	4732	329624	60.94	317236	67.0407	5070.5	-0.861447		2 mM
101988	101433	913	127273	124739	927	101710	111.403	126006	135.929			cell number censor	10 mM
122293	122501	1000	135445	129828	1047	122397	122.397	132636	126.682			cell number censor	2 mM
316688	312699	1842	298171	292561	1315	314694	170.843	295366	224.613			cell number censor	10 mM
258618	257273	4710	308202	299107	4705	257946	54.7655	303654	64.5387	4707.5	-1.00696		2 mM
70324	70701	868	77408	74279	811	70512.5	81.2356	75843.5	93.5185			cell number censor	10 mM
73576	72866	842	81944	78131	830	73221	86.9608	80037.5	96.4307			cell number censor	2 mM
138603	137684	180	161874	155778	147	138144	767.464	158826	1080.45			cell number censor	10 mM
368812	365517	4887	445802	425830	4751	367164	75.1309	435816	91.7314	4819	-0.215527		2 mM
359852	345717	5201	364558	356321	4142	352784	67.8301	360440	87.0206	4671.5	-0.4164		10 mM
353919	347636	5169	378702	373151	5130	350778	67.8618	375926	73.28	5149.5	-0.641841		2 mM
263483	256439	4783	312776	297786	4679	259961	54.351	305281	65.2449	4731	-1.00235		10 mM
69598	71606	920	86471	85522	1026	70602	76.7413	85996.5	83.8173			cell number censor	2 mM
358841	347359	4602	354858	348321	4956	353100	76.7275	351590	70.9422	4779	-0.530435		400 uM
354573	346532	5377	378990	366658	5229	350552	65.1948	372824	71.2993	5303	-0.719494		80 uM
316098	310121	4700	323640	306279	4397	313110	66.619	314960	71.6305	4548.5	-0.689973		400 uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL914576

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 3
First Page: 1055
Last Page: 1063
DOI: 10.1128/aac.01063-06

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1002464

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	2.5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1002463

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1003250

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	40	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1002465

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	1.9	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1228037

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2010
Volume: 18
Issue: 17
First Page: 6398
Last Page: 6403
DOI: 10.1016/j.bmc.2010.07.008

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	8	ug.mL-1
IC50	=	4	ug.mL-1
IC50	=	8	ug.mL-1
IC50	=	4	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL914581

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 3
First Page: 1055
Last Page: 1063
DOI: 10.1128/aac.01063-06

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	7.56	umol/min/mg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1005769

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1005768

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1005771

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1005770

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	40	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1004971

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1004970

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1005767

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	40	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1004972

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1005777

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
FC	=	2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis variant bovis

External ID: CHEMBL1005779

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL613086
ChEMBL Target Name: Mycobacterium tuberculosis variant bovis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1005778

Protocol: N/A

Comment: Journal: Antimicrob Agents Chemother
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
FC	=	8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycobacterium tuberculosis

External ID: CHEMBL1005772

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Target ChEMBL ID: CHEMBL360
ChEMBL Target Name: Mycobacterium tuberculosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
MIC	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：15621 靶标：G protein-activated inward rectifier potassium channel 2

External ID: VANDERBILT_HTS_GIRK2_MPD

Protocol: To screen for modulators of the G protein-gated inwardly-rectifying potassium channel subunit 2 (GIRK2) homomeric channels, HEK293 cells were engineered to overexpress GIRK2. These cells were screened using a high-throughput thallium-flux assay in a 384-well format. High-throughput thallium flux assays are based on three principles: (1) extracellular thallium can permeate through potassium channels into cells, (2) the fluorescent dye Thallos enters and stays in the cytoplasm of HEK293 cells, and (3) the fluorescence of Thallos increases dramatically when it interacts with thallium ions. Compounds that modulate the activity of an overexpressed channel, in this case GIRK2, are identified by the change in fluorescence that results from changes in thallium influx into cells through the overexpressed channel.

The screening protocol was conducted as follows. One hour prior to screening, cells were loaded with 1.5 micromolar (muM) Thallos in assay buffer (1x Hank's Balanced Salt Solution and 20 millimolar (mM) HEPES). The liquid handling and imaging was conducted using a kinetic-imaging plate reader, Panoptic (WaveFront Biosciences). Before screening, Thallos-containing buffer was removed from cells and replaced with 20 microliters (muL) per well of assay buffer. Compounds were dissolved in assay buffer at 20 muM. After 8 seconds of imaging, 20 muL of compound solution was added per well and allowed to incubate for 150 seconds. Next, 10 muL of a solution containing 2.0 mM thallium in Base Buffer (125 mM NaHCO3, 1 mM MgSO4, 1.8 mM CaSO4, 5mM Glucose, and 20 mM HEPES) was added to the wells. 30 seconds later, 12 muL of base buffer containing 2.0 mM thallium and 50 mM 2-methyl-2,4-pentanediol (MPD), a partially-activating concentration, was added to each well. MPD has is a previously-described GIRK2 channel activator. Data was collected for 60 seconds after this final addition. The positive control for this screen was 30 muM ivermectin, a natural product previously identified as a GIRK2 activator as part of a small-scale pilot screen. Microsoft Excel was utilized for data analysis. Data were normalized, F/Fo, on a well-to-well basis to account for differences in cell number. Compound activity was analyzed by comparing the sums of control-subtracted amplitudes of fluorescence intensity at 20 seconds after each thallium addition. The top 0.2% compounds corresponding to wells that demonstrated the largest increases in fluorescence were selected as "hits" for counter screening, as described below.

All 63,228 compounds screened using the method described above are listed in column OUTCOME_SCREEN_HITS. The 133 compounds selected as hits based on the above criteria are labelled with "100" in the ACTIVITY column. Fluorescent compounds were included in the inactive compounds and marked with "0" in the ACTIVITY column.

The 133 active compounds from column OUTCOME_SCREEN_HITS were tested for non-specific activity in untransfected HEK293 cells using assay conditions otherwise identical to the primary screen. Column OUTCOME_HEK_COUNTERSCREEN lists the 23 compounds that displayed an increase in fluorescence upon thallium addition with "100" in the ACTIVITY column.

The 110 compounds which were identified as hits in the primary screen but inactive when tested in untransfected HEK293 cells were tested for activity in GIRK2-overexpressing HEK293 cells that did not express NPY4 receptor. Column OUTCOME_GIRK2_COUNTERSCREEN lists the 44 compound that displayed an increase in fluorescence upon thallium addition with "100" in the ACTIVITY column.

The 44 active compounds from column OUTCOME_GIRK2_COUNTERSCREEN were tested at various concentrations to determine if compound activity was concentration dependent. Column OUTCOME_GIRK2_DOSE_RESPONSE provides the efficacy of these compounds; activity of all compounds at the provided concentrations was normalized to the activity of VU0537695 at 25 muM, which was the highest efficacy observed during this screening. For each compound concentration listed, the efficacy of that compound provided refers to the normalized, control-subtracted fluorescence intensity at 15 seconds after the addition of thallium. The 28 compounds that demonstrated >5% efficacy and concentration-dependent activity were labelled as "100" in the ACTIVITY column.

Finally, column PUBCHEM_ACTIVITY_OUTCOME combines all of the information from the above counterscreens together, indicating the 28 hits from this GIRK2 screen.

Comment:

OUTCOME_SCREEN_HITS	OUTCOME_HEK_COUNTERSCREEN	OUTCOME_GIRK2_COUNTERSCREEN	OUTCOME_GIRK2_DOSE_RESPONSE	% Efficacy @ 25uM	% Efficacy @ 8.3uM	% Efficacy @ 2.8uM	% Efficacy @ 0.94uM	% Efficacy @ 0.15uM	% Efficacy @ 0.024uM
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE
INACTIVE

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1005785

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	54.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1005784

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1005787

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1005786

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	0.1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1005781

Protocol: N/A

Comment: Journal: Antimicrob. Agents Chemother.
Year: 2007
Volume: 51
Issue: 11
First Page: 3824
Last Page: 3829
DOI: 10.1128/aac.00433-07

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	4.4	%

910-86-1 靶点实验数据