HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL700102

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1998
Volume: 41
Issue: 20
First Page: 3845
Last Page: 3856
DOI: 10.1021/jm980144c

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Activity	=	133
Activity	=	1.5
Activity	=	3
Activity	=	150
Activity	=	10
Activity	=	80
Activity	=	133
Activity	=	50
Activity	=	80
Activity	=	75
Activity	=	9
Activity	=	2.5
Activity	=	5
Activity	=	10
Activity	=	4
Activity	=	1
Activity	=	2
Activity	=	10
Activity	=	40
Activity	=	4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_12070_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	Ki	Target Accession(s)	Ligand	Target
Ki	0.00825	8.25	P28223	BDBM50005267	5-hydroxytryptamine receptor 2A
Ki	0.00631	6.31	P28223	BDBM50005267	5-hydroxytryptamine receptor 2A
Ki	4.09	4090	P28223	BDBM50014994	5-hydroxytryptamine receptor 2A
Ki	0.416	416	P28223	BDBM50026868	5-hydroxytryptamine receptor 2A
Ki	0.0158	15.8	P28223	BDBM50038370	5-hydroxytryptamine receptor 2A
Ki	17.4	17400	P28223	BDBM50059891	5-hydroxytryptamine receptor 2A
Ki	0.0586	58.6	P28223	BDBM50081701	5-hydroxytryptamine receptor 2A
Ki	0.00203	2.03	P28223	BDBM50164318	5-hydroxytryptamine receptor 2A
Ki	0.00158	1.58	P28223	BDBM50164318	5-hydroxytryptamine receptor 2A
Ki	0.00954	9.54	P28223	BDBM50164338	5-hydroxytryptamine receptor 2A
Ki	0.00271	2.71	P28223	BDBM50593194	5-hydroxytryptamine receptor 2A
Ki	0.00252	2.52	P28223	BDBM674338	5-hydroxytryptamine receptor 2A
Ki	0.101	101	P28223	BDBM674348	5-hydroxytryptamine receptor 2A
Ki	0.00179	1.79	P28223	BDBM674351	5-hydroxytryptamine receptor 2A
Ki	0.00305	3.05	P28223	BDBM674352	5-hydroxytryptamine receptor 2A
Ki	0.249	249	P28223	BDBM674361	5-hydroxytryptamine receptor 2A
Ki	0.0229	22.9	P28223	BDBM676126	5-hydroxytryptamine receptor 2A
Ki	0.0108	10.8	P28223	BDBM676127	5-hydroxytryptamine receptor 2A
Ki	0.0194	19.4	P28223	BDBM676130	5-hydroxytryptamine receptor 2A
Ki	0.0388	38.8	P28223	BDBM676131	5-hydroxytryptamine receptor 2A

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL696016

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 2
First Page: 687
Last Page: 702
DOI: 10.1021/jm00164a036

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	3	MU
Activity	=	20	MU
Activity	=	40	MU
Activity	=	80	MU
Activity	=	80	MU
Activity	=	100	MU
Activity	=	20	MU
Activity	=	8	MU
Activity	=	5	MU
Activity	=	0.5	MU
Activity	<	0.2	MU
Activity	=	12	MU
Activity	=	6	MU
Activity	<	1	MU
Activity	=	1	MU
Activity	=	2	MU
Activity	=	2	MU
Activity	=	10	MU
Activity	=	5	MU
Activity	=	40	MU

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL699010

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 7
First Page: 881
Last Page: 888
DOI: 10.1021/jm00373a013

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Relative activity	=	12
Relative activity	=	6
Relative activity	=	3
Relative activity	=	16
Relative activity	=	2
Relative activity	=	2
Relative activity	=	4
Relative activity	=	20
Relative activity	=	4
Relative activity	=	6
Relative activity	=	6
Relative activity	=	1.5
Relative activity	=	1
Relative activity	=	10
Relative activity	<	1
Relative activity	<	1
Relative activity	=	2
Relative activity	<	1
Relative activity	<	1
Relative activity	<	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Homo sapiens

External ID: CHEMBL631963

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 2
First Page: 687
Last Page: 702
DOI: 10.1021/jm00164a036

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Log activity	=	0.477
Log activity	=	1.301
Log activity	=	1.602
Log activity	=	1.903
Log activity	=	1.903
Log activity	=	2
Log activity	=	1.301
Log activity	=	0.903
Log activity	=	0.699
Log activity	=	-0.301
Log activity	=	-1
Log activity	=	1.079
Log activity	=	0.778
Log activity	=	-0.301
Log activity	=	0
Log activity	=	0.301
Log activity	=	0.301
Log activity	=	1
Log activity	=	0.699
Log activity	=	1.602

90109-57-2 靶点实验数据