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89987-06-4 靶点实验数据

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909317
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepSE_liver disease=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909316
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_jaundice=0
HepSE_jaundice=0
HepSE_jaundice=1
HepSE_jaundice=0
HepSE_jaundice=1
HepSE_jaundice=1
HepSE_jaundice=1
HepSE_jaundice=0
HepSE_jaundice=0
HepSE_jaundice=1
HepSE_jaundice=1
HepSE_jaundice=0
HepSE_jaundice=1
HepSE_jaundice=1
HepSE_jaundice=1
HepSE_jaundice=1
HepSE_jaundice=0
HepSE_jaundice=0
HepSE_jaundice=0
HepSE_jaundice=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909319
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=1
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=1
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepSE_liver function tests abnormal=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909318
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepSE_liver fatty=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909320
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_Combined Scores=0
HepSE_Combined Scores=0
HepSE_Combined Scores=6
HepSE_Combined Scores=0
HepSE_Combined Scores=1
HepSE_Combined Scores=7
HepSE_Combined Scores=5
HepSE_Combined Scores=0
HepSE_Combined Scores=0
HepSE_Combined Scores=1
HepSE_Combined Scores=3
HepSE_Combined Scores=0
HepSE_Combined Scores=3
HepSE_Combined Scores=3
HepSE_Combined Scores=1
HepSE_Combined Scores=2
HepSE_Combined Scores=0
HepSE_Combined Scores=0
HepSE_Combined Scores=1
HepSE_Combined Scores=3
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909309
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=1
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepSE_cholelithiasis=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909308
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=1
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepSE_cholecystitis=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909311
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=1
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepSE_elevated liver function tests=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909310
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepSE_cirrhosis=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909313
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=1
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=1
HepSE_hepatic necrosis=1
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=0
HepSE_hepatic necrosis=1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909312
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=1
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=1
HepSE_hepatic failure=1
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=1
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepSE_hepatic failure=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909315
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=1
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepSE_hepatomegaly=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Hepatotoxicity
External ID: CHEMBL1909314
Protocol: N/A
Comment: Journal: PLoS Comput Biol
Year: 2011
Volume: 7
Issue: 12
First Page: 1
Last Page: 13
DOI: 10.1371/journal.pcbi.1002310

Target ChEMBL ID: CHEMBL1697861
ChEMBL Target Name: Hepatotoxicity
ChEMBL Target Type: PHENOTYPE - Target is a biological phenotype or process
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
HepSE_hepatitis=0
HepSE_hepatitis=0
HepSE_hepatitis=1
HepSE_hepatitis=0
HepSE_hepatitis=0
HepSE_hepatitis=1
HepSE_hepatitis=1
HepSE_hepatitis=0
HepSE_hepatitis=0
HepSE_hepatitis=0
HepSE_hepatitis=1
HepSE_hepatitis=0
HepSE_hepatitis=1
HepSE_hepatitis=0
HepSE_hepatitis=0
HepSE_hepatitis=1
HepSE_hepatitis=0
HepSE_hepatitis=0
HepSE_hepatitis=1
HepSE_hepatitis=0
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3137727
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2
Standard TypeStandard RelationStandard ValueActivity Comment
Hepatotoxicity (choleostasis)=3references out of a total of 9
Hepatotoxicity (choleostasis)=3references out of a total of 5
Hepatotoxicity (choleostasis)=2references out of a total of 15
Hepatotoxicity (choleostasis)=10references out of a total of 15
Hepatotoxicity (choleostasis)=0references out of a total of 6
Hepatotoxicity (choleostasis)=6references out of a total of 31
Hepatotoxicity (choleostasis)=12references out of a total of 33
Hepatotoxicity (choleostasis)=1references out of a total of 2
Hepatotoxicity (choleostasis)=10references out of a total of 33
Hepatotoxicity (choleostasis)=1references out of a total of 33
Hepatotoxicity (choleostasis)=11references out of a total of 69
Hepatotoxicity (choleostasis)=0references out of a total of 1
Hepatotoxicity (choleostasis)=4references out of a total of 58
Hepatotoxicity (choleostasis)=55references out of a total of 90
Hepatotoxicity (choleostasis)=1references out of a total of 5
Hepatotoxicity (choleostasis)=0references out of a total of 1
Hepatotoxicity (choleostasis)=2references out of a total of 6
Hepatotoxicity (choleostasis)=0references out of a total of 4
Hepatotoxicity (choleostasis)=0references out of a total of 8
Hepatotoxicity (choleostasis)=0references out of a total of 16
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3137728
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2
Standard TypeStandard RelationStandard ValueActivity Comment
Hepatotoxicity (severe hepatitis)=0references out of a total of 1
Hepatotoxicity (severe hepatitis)=2references out of a total of 69
Hepatotoxicity (severe hepatitis)=0references out of a total of 5
Hepatotoxicity (severe hepatitis)=5references out of a total of 27
Hepatotoxicity (severe hepatitis)=0references out of a total of 13
Hepatotoxicity (severe hepatitis)=0references out of a total of 1
Hepatotoxicity (severe hepatitis)=5references out of a total of 132
Hepatotoxicity (severe hepatitis)=0references out of a total of 23
Hepatotoxicity (severe hepatitis)=0references out of a total of 1
Hepatotoxicity (severe hepatitis)=0references out of a total of 9
Hepatotoxicity (severe hepatitis)=5references out of a total of 34
Hepatotoxicity (severe hepatitis)=1references out of a total of 5
Hepatotoxicity (severe hepatitis)=21references out of a total of 53
Hepatotoxicity (severe hepatitis)=1references out of a total of 1
Hepatotoxicity (severe hepatitis)=1references out of a total of 14
Hepatotoxicity (severe hepatitis)=0references out of a total of 5
Hepatotoxicity (severe hepatitis)=0references out of a total of 3
Hepatotoxicity (severe hepatitis)=1references out of a total of 16
Hepatotoxicity (severe hepatitis)=14references out of a total of 123
Hepatotoxicity (severe hepatitis)=0references out of a total of 4
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3137729
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2
Standard TypeStandard RelationStandard ValueActivity Comment
Hepatotoxicity (chronic liver disease)=0references out of a total of 1
Hepatotoxicity (chronic liver disease)=0references out of a total of 69
Hepatotoxicity (chronic liver disease)=0references out of a total of 5
Hepatotoxicity (chronic liver disease)=0references out of a total of 27
Hepatotoxicity (chronic liver disease)=0references out of a total of 13
Hepatotoxicity (chronic liver disease)=0references out of a total of 1
Hepatotoxicity (chronic liver disease)=1references out of a total of 132
Hepatotoxicity (chronic liver disease)=0references out of a total of 23
Hepatotoxicity (chronic liver disease)=0references out of a total of 1
Hepatotoxicity (chronic liver disease)=0references out of a total of 9
Hepatotoxicity (chronic liver disease)=1references out of a total of 34
Hepatotoxicity (chronic liver disease)=0references out of a total of 5
Hepatotoxicity (chronic liver disease)=1references out of a total of 53
Hepatotoxicity (chronic liver disease)=0references out of a total of 1
Hepatotoxicity (chronic liver disease)=0references out of a total of 14
Hepatotoxicity (chronic liver disease)=0references out of a total of 5
Hepatotoxicity (chronic liver disease)=0references out of a total of 3
Hepatotoxicity (chronic liver disease)=0references out of a total of 16
Hepatotoxicity (chronic liver disease)=6references out of a total of 123
Hepatotoxicity (chronic liver disease)=0references out of a total of 4
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3137730
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2
Standard TypeStandard RelationStandard ValueActivity Comment
Hepatotoxicity (cirrhosis)=0references out of a total of 1
Hepatotoxicity (cirrhosis)=0references out of a total of 69
Hepatotoxicity (cirrhosis)=0references out of a total of 5
Hepatotoxicity (cirrhosis)=0references out of a total of 27
Hepatotoxicity (cirrhosis)=0references out of a total of 13
Hepatotoxicity (cirrhosis)=0references out of a total of 1
Hepatotoxicity (cirrhosis)=0references out of a total of 132
Hepatotoxicity (cirrhosis)=0references out of a total of 23
Hepatotoxicity (cirrhosis)=0references out of a total of 1
Hepatotoxicity (cirrhosis)=0references out of a total of 9
Hepatotoxicity (cirrhosis)=0references out of a total of 34
Hepatotoxicity (cirrhosis)=0references out of a total of 5
Hepatotoxicity (cirrhosis)=0references out of a total of 53
Hepatotoxicity (cirrhosis)=0references out of a total of 1
Hepatotoxicity (cirrhosis)=0references out of a total of 14
Hepatotoxicity (cirrhosis)=0references out of a total of 5
Hepatotoxicity (cirrhosis)=0references out of a total of 3
Hepatotoxicity (cirrhosis)=0references out of a total of 16
Hepatotoxicity (cirrhosis)=0references out of a total of 123
Hepatotoxicity (cirrhosis)=0references out of a total of 4
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:NON-PROTEIN TARGET
External ID: CHEMBL3137731
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueActivity Comment
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 1
Hepatotoxicity (granulomatous hepatitis)=1references out of a total of 69
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 5
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 27
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 13
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 1
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 132
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 23
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 1
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 9
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 34
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 5
Hepatotoxicity (granulomatous hepatitis)=1references out of a total of 53
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 1
Hepatotoxicity (granulomatous hepatitis)=1references out of a total of 14
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 5
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 3
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 16
Hepatotoxicity (granulomatous hepatitis)=5references out of a total of 123
Hepatotoxicity (granulomatous hepatitis)=0references out of a total of 4
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3137732
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2
Standard TypeStandard RelationStandard ValueActivity Comment
Hepatotoxicity (association with vascular disease)=0references out of a total of 1
Hepatotoxicity (association with vascular disease)=0references out of a total of 69
Hepatotoxicity (association with vascular disease)=0references out of a total of 5
Hepatotoxicity (association with vascular disease)=0references out of a total of 27
Hepatotoxicity (association with vascular disease)=0references out of a total of 13
Hepatotoxicity (association with vascular disease)=0references out of a total of 1
Hepatotoxicity (association with vascular disease)=0references out of a total of 132
Hepatotoxicity (association with vascular disease)=0references out of a total of 23
Hepatotoxicity (association with vascular disease)=0references out of a total of 1
Hepatotoxicity (association with vascular disease)=0references out of a total of 9
Hepatotoxicity (association with vascular disease)=0references out of a total of 34
Hepatotoxicity (association with vascular disease)=0references out of a total of 5
Hepatotoxicity (association with vascular disease)=0references out of a total of 53
Hepatotoxicity (association with vascular disease)=0references out of a total of 1
Hepatotoxicity (association with vascular disease)=0references out of a total of 14
Hepatotoxicity (association with vascular disease)=0references out of a total of 5
Hepatotoxicity (association with vascular disease)=0references out of a total of 3
Hepatotoxicity (association with vascular disease)=1references out of a total of 16
Hepatotoxicity (association with vascular disease)=0references out of a total of 123
Hepatotoxicity (association with vascular disease)=2references out of a total of 4
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3137733
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2
Standard TypeStandard RelationStandard ValueActivity Comment
Hepatotoxicity (steatosis)=0references out of a total of 1
Hepatotoxicity (steatosis)=0references out of a total of 69
Hepatotoxicity (steatosis)=0references out of a total of 5
Hepatotoxicity (steatosis)=0references out of a total of 27
Hepatotoxicity (steatosis)=0references out of a total of 13
Hepatotoxicity (steatosis)=0references out of a total of 1
Hepatotoxicity (steatosis)=1references out of a total of 132
Hepatotoxicity (steatosis)=0references out of a total of 23
Hepatotoxicity (steatosis)=0references out of a total of 1
Hepatotoxicity (steatosis)=0references out of a total of 9
Hepatotoxicity (steatosis)=0references out of a total of 34
Hepatotoxicity (steatosis)=0references out of a total of 5
Hepatotoxicity (steatosis)=2references out of a total of 53
Hepatotoxicity (steatosis)=0references out of a total of 1
Hepatotoxicity (steatosis)=0references out of a total of 14
Hepatotoxicity (steatosis)=0references out of a total of 5
Hepatotoxicity (steatosis)=0references out of a total of 3
Hepatotoxicity (steatosis)=0references out of a total of 16
Hepatotoxicity (steatosis)=4references out of a total of 123
Hepatotoxicity (steatosis)=0references out of a total of 4
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3137734
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2
Standard TypeStandard RelationStandard ValueActivity Comment
Hepatotoxicity (malignant tumour)=0references out of a total of 1
Hepatotoxicity (malignant tumour)=0references out of a total of 69
Hepatotoxicity (malignant tumour)=0references out of a total of 5
Hepatotoxicity (malignant tumour)=0references out of a total of 27
Hepatotoxicity (malignant tumour)=0references out of a total of 13
Hepatotoxicity (malignant tumour)=0references out of a total of 1
Hepatotoxicity (malignant tumour)=0references out of a total of 132
Hepatotoxicity (malignant tumour)=0references out of a total of 23
Hepatotoxicity (malignant tumour)=0references out of a total of 1
Hepatotoxicity (malignant tumour)=0references out of a total of 9
Hepatotoxicity (malignant tumour)=0references out of a total of 34
Hepatotoxicity (malignant tumour)=0references out of a total of 5
Hepatotoxicity (malignant tumour)=0references out of a total of 53
Hepatotoxicity (malignant tumour)=0references out of a total of 1
Hepatotoxicity (malignant tumour)=0references out of a total of 14
Hepatotoxicity (malignant tumour)=0references out of a total of 5
Hepatotoxicity (malignant tumour)=0references out of a total of 3
Hepatotoxicity (malignant tumour)=6references out of a total of 16
Hepatotoxicity (malignant tumour)=0references out of a total of 123
Hepatotoxicity (malignant tumour)=0references out of a total of 4
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:NON-PROTEIN TARGET
External ID: CHEMBL3137735
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard ValueActivity Comment
Hepatotoxicity (benign tumour)=0references out of a total of 1
Hepatotoxicity (benign tumour)=0references out of a total of 69
Hepatotoxicity (benign tumour)=0references out of a total of 5
Hepatotoxicity (benign tumour)=0references out of a total of 27
Hepatotoxicity (benign tumour)=0references out of a total of 13
Hepatotoxicity (benign tumour)=0references out of a total of 1
Hepatotoxicity (benign tumour)=0references out of a total of 132
Hepatotoxicity (benign tumour)=0references out of a total of 23
Hepatotoxicity (benign tumour)=0references out of a total of 1
Hepatotoxicity (benign tumour)=0references out of a total of 9
Hepatotoxicity (benign tumour)=0references out of a total of 34
Hepatotoxicity (benign tumour)=0references out of a total of 5
Hepatotoxicity (benign tumour)=0references out of a total of 53
Hepatotoxicity (benign tumour)=0references out of a total of 1
Hepatotoxicity (benign tumour)=0references out of a total of 14
Hepatotoxicity (benign tumour)=0references out of a total of 5
Hepatotoxicity (benign tumour)=0references out of a total of 3
Hepatotoxicity (benign tumour)=0references out of a total of 16
Hepatotoxicity (benign tumour)=0references out of a total of 123
Hepatotoxicity (benign tumour)=0references out of a total of 4
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:NON-PROTEIN TARGET
External ID: CHEMBL3137736
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeActivity Comment
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)yes
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)yes
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)yes
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)
Hepatotoxicity (animal toxicity known)yes
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3137737
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2
Standard TypeActivity Comment
Hepatotoxicity (successful reintroduction)yes
Hepatotoxicity (successful reintroduction)yes
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)yes
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
Hepatotoxicity (successful reintroduction)
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL3137738
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2
Standard TypeActivity Comment
Hepatotoxicity (comment)
Hepatotoxicity (comment)I/PYRAZINAMIDE
Hepatotoxicity (comment)
Hepatotoxicity (comment)
Hepatotoxicity (comment)
Hepatotoxicity (comment)
Hepatotoxicity (comment)DUCTOPENIE AC_ANTI-N/-ADN
Hepatotoxicity (comment)AC_ANTI-N
Hepatotoxicity (comment)
Hepatotoxicity (comment)RC/NOMIFENSINE
Hepatotoxicity (comment)RC/DESPRAMINE CHOLESTASE_PROLONGEE
Hepatotoxicity (comment)
Hepatotoxicity (comment)CHOLESTASE_PROLONGEE
Hepatotoxicity (comment)
Hepatotoxicity (comment)AC_ANTI-N/-M #CBP
Hepatotoxicity (comment)ENCEPHALOPATHIE
Hepatotoxicity (comment)
Hepatotoxicity (comment)ANGIOSARCOME RC/TAMOXIFENE
Hepatotoxicity (comment)#MNI CHOLESTASE_PROLONGEE DUCTOPENIE #CBP
Hepatotoxicity (comment)MVO PELIOSE
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:NON-PROTEIN TARGET
External ID: CHEMBL3137739
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeActivity Comment
Hepatotoxicity (time to onset)
Hepatotoxicity (time to onset)4 days - 26 weeks
Hepatotoxicity (time to onset)2 weeks
Hepatotoxicity (time to onset)3 days - 10 years
Hepatotoxicity (time to onset)
Hepatotoxicity (time to onset)
Hepatotoxicity (time to onset)2 days - 6 months
Hepatotoxicity (time to onset)1 day - 10 days
Hepatotoxicity (time to onset)
Hepatotoxicity (time to onset)1 day - 1.8 years
Hepatotoxicity (time to onset)1 week - 1 year
Hepatotoxicity (time to onset)6 months - 5 years
Hepatotoxicity (time to onset)3 days - 2.3 years
Hepatotoxicity (time to onset)2 days
Hepatotoxicity (time to onset)2 days - 9 years
Hepatotoxicity (time to onset)5 days - 17 days
Hepatotoxicity (time to onset)1 week
Hepatotoxicity (time to onset)4 days - 15 years
Hepatotoxicity (time to onset)1 day - 11 years
Hepatotoxicity (time to onset)1 month - 3 months
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:NON-PROTEIN TARGET
External ID: CHEMBL3137740
Protocol: N/A
Comment: Journal: Gastroenterol Clin Biol
Year: 2004
Volume: 28
Issue: 8-9
First Page: 720
Last Page: 759
DOI: 10.1016/s0399-8320(04)95062-2

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeActivity Comment
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)Allergic
Hepatotoxicity (mechanism)Allergic, Reactive metabolite
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)Allergic, Dose-dependant
Hepatotoxicity (mechanism)Allergic
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)Dose-dependant, Reactive metabolite
Hepatotoxicity (mechanism)Allergic, Reactive metabolite
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)Mitochondrial toxicity
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)Allergic
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)
Hepatotoxicity (mechanism)Allergic, Reactive metabolite
Hepatotoxicity (mechanism)
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:IUPHAR-DB 靶标:MMP2 (M10: Matrix metallopeptidase) [Homo sapiens]
External ID: 1629_Human
Protocol: The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY Database (GtoPdb) uses expert subcommittees to collate peer-reviewed information from the published literature regarding individual protein targets, and describes the pharmacology, genetics, function and anatomy of each target. Its pages provide a richly curated overview of the pharmacology of receptors, ion channels, enzymes and other target types, which can be found by following the external link to the GtoPdb website.

Comment: The data collected focuses on ligands at human receptors. Data are provided at rat or mouse orthologues where there are significant species differences, or where data are not yet available at the human target.

Information on individual experimental protocols can be found in the primary references listed for each ligand.

Affinity data are expressed as pKi [-log(Ki)], pKd [-log(Kd)], pIC50 [-log(IC50)], pEC50 [-log(EC50)], pKB [-log(KB)], pA2 or as a micromolar concentration range. In most cases the original concentration can be found in the primary reference.
pKi_minpKi_maxpIC50_minpIC50_maxTypeActionReference (PubMed ID)
8.58.5InhibitorInhibition
7.67.6InhibitorInhibition21514700
7.97.9InhibitorInhibition
InhibitorInhibition16483784
88InhibitorInhibition16680577
8.18.1InhibitorInhibition14684295
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Severe acute respiratory syndrome coronavirus 2
External ID: CHEMBL4513082
Protocol: N/A
Comment: Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: SARS-CoV-2 Screening Data
Standard TypeStandard RelationStandard ValueStandard Units
Inhibition=0.24%
Inhibition=4.58%
Inhibition=-0.3%
Inhibition=-0.3%
Inhibition=-0.04%
Inhibition=-0.04%
Inhibition=-0.08%
Inhibition=-0.08%
Inhibition=-0.08%
Inhibition=-0.08%
Inhibition=0.03%
Inhibition=0%
Inhibition=0.03%
Inhibition=0%
Inhibition=-0.27%
Inhibition=-0.27%
Inhibition=-0.08%
Inhibition=-0.08%
Inhibition=14.41%
Inhibition=0.39%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614677
Protocol: N/A
Comment: Journal: J Pharm Sci
Year: 2005
Volume: 94
Issue: 7
First Page: 1467
Last Page: 1483
DOI: 10.1002/jps.20373
Standard TypeStandard RelationStandard ValueStandard Units
CL=42mL.min-1.kg-1
CL=0.002mL.min-1.kg-1
CL=1.6mL.min-1.kg-1
CL=3.8mL.min-1.kg-1
CL=18mL.min-1.kg-1
CL=180mL.min-1.kg-1
CL=6.6mL.min-1.kg-1
CL=23mL.min-1.kg-1
CL=2.8mL.min-1.kg-1
CL=22mL.min-1.kg-1
CL=34mL.min-1.kg-1
CL=3.7mL.min-1.kg-1
CL=12mL.min-1.kg-1
CL=11mL.min-1.kg-1
CL=1.3mL.min-1.kg-1
CL=50mL.min-1.kg-1
CL=3.9mL.min-1.kg-1
CL=50mL.min-1.kg-1
CL=37mL.min-1.kg-1
CL=67mL.min-1.kg-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614678
Protocol: N/A
Comment: Journal: J Pharm Sci
Year: 2005
Volume: 94
Issue: 7
First Page: 1467
Last Page: 1483
DOI: 10.1002/jps.20373
Standard TypeStandard RelationStandard ValueStandard Units
Vdss=3.3L.kg-1
Vdss=7.4L.kg-1
Vdss=1.3L.kg-1
Vdss=1L.kg-1
Vdss=3.1L.kg-1
Vdss=3L.kg-1
Vdss=0.77L.kg-1
Vdss=4.5L.kg-1
Vdss=1L.kg-1
Vdss=6.5L.kg-1
Vdss=1.7L.kg-1
Vdss=2.7L.kg-1
Vdss=0.23L.kg-1
Vdss=1.6L.kg-1
Vdss=0.33L.kg-1
Vdss=17L.kg-1
Vdss=1L.kg-1
Vdss=4L.kg-1
Vdss=2.1L.kg-1
Vdss=0.9L.kg-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614679
Protocol: N/A
Comment: Journal: J Pharm Sci
Year: 2005
Volume: 94
Issue: 7
First Page: 1467
Last Page: 1483
DOI: 10.1002/jps.20373
Standard TypeStandard RelationStandard ValueStandard Units
CL=14mL.min-1.kg-1
CL=13mL.min-1.kg-1
CL=4mL.min-1.kg-1
CL=13.5mL.min-1.kg-1
CL=4.7mL.min-1.kg-1
CL=59mL.min-1.kg-1
CL=8.3mL.min-1.kg-1
CL=30mL.min-1.kg-1
CL=7.9mL.min-1.kg-1
CL=34mL.min-1.kg-1
CL=14mL.min-1.kg-1
CL=12mL.min-1.kg-1
CL=2.9mL.min-1.kg-1
CL=14mL.min-1.kg-1
CL=0.6mL.min-1.kg-1
CL=37mL.min-1.kg-1
CL=11mL.min-1.kg-1
CL=34mL.min-1.kg-1
CL=66mL.min-1.kg-1
CL=58mL.min-1.kg-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614680
Protocol: N/A
Comment: Journal: J Pharm Sci
Year: 2005
Volume: 94
Issue: 7
First Page: 1467
Last Page: 1483
DOI: 10.1002/jps.20373
Standard TypeStandard RelationStandard ValueStandard Units
Vdss=1.5L.kg-1
Vdss=1.8L.kg-1
Vdss=1.2L.kg-1
Vdss=1.4L.kg-1
Vdss=1.8L.kg-1
Vdss=1.7L.kg-1
Vdss=0.71L.kg-1
Vdss=3L.kg-1
Vdss=7.8L.kg-1
Vdss=4.5L.kg-1
Vdss=0.6L.kg-1
Vdss=4.9L.kg-1
Vdss=0.11L.kg-1
Vdss=6.8L.kg-1
Vdss=0.09L.kg-1
Vdss=7.3L.kg-1
Vdss=2.1L.kg-1
Vdss=12L.kg-1
Vdss=0.98L.kg-1
Vdss=0.9L.kg-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614681
Protocol: N/A
Comment: Journal: J Pharm Sci
Year: 2005
Volume: 94
Issue: 7
First Page: 1467
Last Page: 1483
DOI: 10.1002/jps.20373
Standard TypeStandard RelationStandard ValueStandard Units
CL=19mL.min-1.kg-1
CL=2mL.min-1.kg-1
CL=2.4mL.min-1.kg-1
CL=4.5mL.min-1.kg-1
CL=1.4mL.min-1.kg-1
CL=3.6mL.min-1.kg-1
CL=3.5mL.min-1.kg-1
CL=15mL.min-1.kg-1
CL=0.57mL.min-1.kg-1
CL=17mL.min-1.kg-1
CL=15mL.min-1.kg-1
CL=2.2mL.min-1.kg-1
CL=2mL.min-1.kg-1
CL=1.6mL.min-1.kg-1
CL=0.35mL.min-1.kg-1
CL=4.9mL.min-1.kg-1
CL=7.4mL.min-1.kg-1
CL=24mL.min-1.kg-1
CL=9.2mL.min-1.kg-1
CL=17mL.min-1.kg-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614682
Protocol: N/A
Comment: Journal: J Pharm Sci
Year: 2005
Volume: 94
Issue: 7
First Page: 1467
Last Page: 1483
DOI: 10.1002/jps.20373
Standard TypeStandard RelationStandard ValueStandard Units
Vdss=2.6L.kg-1
Vdss=0.26L.kg-1
Vdss=1.5L.kg-1
Vdss=1.6L.kg-1
Vdss=2.3L.kg-1
Vdss=0.05L.kg-1
Vdss=0.71L.kg-1
Vdss=4.2L.kg-1
Vdss=1.4L.kg-1
Vdss=2.2L.kg-1
Vdss=3.6L.kg-1
Vdss=2L.kg-1
Vdss=0.11L.kg-1
Vdss=5.5L.kg-1
Vdss=0.11L.kg-1
Vdss=6.2L.kg-1
Vdss=3.8L.kg-1
Vdss=3.3L.kg-1
Vdss=1.1L.kg-1
Vdss=0.4L.kg-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614675
Protocol: N/A
Comment: Journal: J Pharm Sci
Year: 2005
Volume: 94
Issue: 7
First Page: 1467
Last Page: 1483
DOI: 10.1002/jps.20373
Standard TypeStandard RelationStandard ValueStandard Units
CL=66mL.min-1.kg-1
CL=0.43mL.min-1.kg-1
CL=5.7mL.min-1.kg-1
CL=12mL.min-1.kg-1
CL=27mL.min-1.kg-1
CL=118mL.min-1.kg-1
CL=22mL.min-1.kg-1
CL=185mL.min-1.kg-1
CL=7.4mL.min-1.kg-1
CL=20mL.min-1.kg-1
CL=92mL.min-1.kg-1
CL=43mL.min-1.kg-1
CL=4.8mL.min-1.kg-1
CL=21mL.min-1.kg-1
CL=3.6mL.min-1.kg-1
CL=122mL.min-1.kg-1
CL=37mL.min-1.kg-1
CL=73mL.min-1.kg-1
CL=47mL.min-1.kg-1
CL=32mL.min-1.kg-1
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614676
Protocol: N/A
Comment: Journal: J Pharm Sci
Year: 2005
Volume: 94
Issue: 7
First Page: 1467
Last Page: 1483
DOI: 10.1002/jps.20373
Standard TypeStandard RelationStandard ValueStandard Units
Vdss=4.7mL/min/kg
Vdss=0.1mL/min/kg
Vdss=1.3mL/min/kg
Vdss=1.5mL/min/kg
Vdss=4.6mL/min/kg
Vdss=4.9mL/min/kg
Vdss=1mL/min/kg
Vdss=7mL/min/kg
Vdss=0.64mL/min/kg
Vdss=1.3mL/min/kg
Vdss=5.3mL/min/kg
Vdss=3.6mL/min/kg
Vdss=0.16mL/min/kg
Vdss=3mL/min/kg
Vdss=0.56mL/min/kg
Vdss=23mL/min/kg
Vdss=3.2mL/min/kg
Vdss=2.9mL/min/kg
Vdss=2.5mL/min/kg
Vdss=0.8mL/min/kg
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614693
Protocol: N/A
Comment: Journal: Xenobiotica
Year: 2005
Volume: 35
Issue: 2
First Page: 191
Last Page: 210
DOI: 10.1080/00498250400028197
Standard TypeStandard RelationStandard ValueStandard Units
DNAUC=218.1kg.min/L
DNAUC=133.1kg.min/L
DNAUC=133.54kg.min/L
DNAUC=85.2kg.min/L
DNAUC=34.08kg.min/L
DNAUC=8.33kg.min/L
DNAUC=31.8kg.min/L
DNAUC=1.32kg.min/L
DNAUC=45.09kg.min/L
DNAUC=43.2kg.min/L
DNAUC=36.8kg.min/L
DNAUC=1912.26kg.min/L
DNAUC=3.79kg.min/L
DNAUC=2.2kg.min/L
DNAUC=259.2kg.min/L
DNAUC=17.52kg.min/L
DNAUC=1.32kg.min/L
DNAUC=9.85kg.min/L
DNAUC=2364.5kg.min/L
DNAUC=39.2kg.min/L
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614694
Protocol: N/A
Comment: Journal: Xenobiotica
Year: 2005
Volume: 35
Issue: 2
First Page: 191
Last Page: 210
DOI: 10.1080/00498250400028197
Standard TypeStandard RelationStandard ValueStandard Units
DNAUC=297.93kg.min/L
DNAUC=488.62kg.min/L
DNAUC=432.41kg.min/L
DNAUC=77.03kg.min/L
DNAUC=80.71kg.min/L
DNAUC=25.33kg.min/L
DNAUC=2.03kg.min/L
DNAUC=17.33kg.min/L
DNAUC=372.73kg.min/L
DNAUC=184.62kg.min/L
DNAUC=590kg.min/L
DNAUC=1256.47kg.min/L
DNAUC=38.04kg.min/L
DNAUC=550.48kg.min/L
DNAUC=505.26kg.min/L
DNAUC=33.15kg.min/L
DNAUC=36.8kg.min/L
DNAUC=200kg.min/L
DNAUC=2900.56kg.min/L
DNAUC=152.38kg.min/L
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL827408
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 5
First Page: 1322
Last Page: 1329
DOI: 10.1021/jm040830d
Standard TypeStandard RelationStandard ValueStandard Units
Affinity=58.4%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL839453
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 5
First Page: 1322
Last Page: 1329
DOI: 10.1021/jm040830d
Standard TypeActivity Comment
BiodistributionNot Determined
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL839452
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 5
First Page: 1322
Last Page: 1329
DOI: 10.1021/jm040830d
Standard TypeActivity Comment
BiodistributionNot Determined
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Replicase polyprotein 1ab
External ID: CHEMBL4495582
Protocol: N/A
Comment: Target ChEMBL ID: CHEMBL4523582
ChEMBL Target Name: Replicase polyprotein 1ab
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SARS-CoV-2 Screening Data
Standard TypeStandard RelationStandard ValueStandard UnitsData Validity Comment
Inhibition=13.77%
Inhibition=2.35%
Inhibition=21.17%
Inhibition=18.36%
Inhibition=5.381%
Inhibition=18.17%
Inhibition=10.15%
Inhibition=29.56%
Inhibition=18.27%
Inhibition=11.42%
Inhibition=15.4%
Inhibition=7.437%
Inhibition=-3.216%
Inhibition=18%
Inhibition=1.021%
Inhibition=16.4%
Inhibition=2.544%
Inhibition=19.11%
Inhibition=26.15%
Inhibition=5.133%
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614691
Protocol: N/A
Comment: Journal: Xenobiotica
Year: 2005
Volume: 35
Issue: 2
First Page: 191
Last Page: 210
DOI: 10.1080/00498250400028197
Standard TypeStandard RelationStandard ValueStandard Units
DNAUC=32.85kg.min/L
DNAUC=2056kg.min/L
DNAUC=152.4kg.min/L
DNAUC=9.36kg.min/L
DNAUC=13.44kg.min/L
DNAUC=58kg.min/L
DNAUC=37.5kg.min/L
DNAUC=37.8kg.min/L
DNAUC=18.35kg.min/L
DNAUC=44.73kg.min/L
DNAUC=3.47kg.min/L
DNAUC=285kg.min/L
DNAUC=1.64kg.min/L
DNAUC=6.07kg.min/L
DNAUC=67.2kg.min/L
DNAUC=11.42kg.min/L
DNAUC=1.88kg.min/L
DNAUC=5.88kg.min/L
DNAUC=1042.5kg.min/L
DNAUC=20kg.min/L
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL839455
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 5
First Page: 1322
Last Page: 1329
DOI: 10.1021/jm040830d
Standard TypeActivity Comment
BiodistributionNot Determined
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL1614692
Protocol: N/A
Comment: Journal: Xenobiotica
Year: 2005
Volume: 35
Issue: 2
First Page: 191
Last Page: 210
DOI: 10.1080/00498250400028197
Standard TypeStandard RelationStandard ValueStandard Units
DNAUC=407.7kg.min/L
DNAUC=793.3kg.min/L
DNAUC=618kg.min/L
DNAUC=32.75kg.min/L
DNAUC=61.2kg.min/L
DNAUC=15.8kg.min/L
DNAUC=40.38kg.min/L
DNAUC=8.32kg.min/L
DNAUC=245.95kg.min/L
DNAUC=57.84kg.min/L
DNAUC=24kg.min/L
DNAUC=1352.94kg.min/L
DNAUC=8.38kg.min/L
DNAUC=101.6kg.min/L
DNAUC=120kg.min/L
DNAUC=140.4kg.min/L
DNAUC=31.38kg.min/L
DNAUC=8.75kg.min/L
DNAUC=4718.5kg.min/L
DNAUC=84kg.min/L
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:N/A
External ID: CHEMBL839454
Protocol: N/A
Comment: Journal: J. Med. Chem.
Year: 2005
Volume: 48
Issue: 5
First Page: 1322
Last Page: 1329
DOI: 10.1021/jm040830d
Standard TypeActivity Comment
BiodistributionNot Determined
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Severe acute respiratory syndrome coronavirus 2
External ID: CHEMBL4303810
Protocol: N/A
Comment: Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: SARS-CoV-2 Screening Data
Standard TypeStandard RelationStandard ValueActivity Comment
Hit score=0.07667
Hit score=0.08432
Hit score=0.03233
Hit score=0.1032N=2 (0.182401631,0.023899107)
Hit score=0.0587
Hit score=0.04532
Hit score=0.1213
Hit score=0.1255
Hit score=0.1871
Hit score=0.2217
Hit score=0.1243
Hit score=0.1603
Hit score=0.2724
Hit score=0.3773
Hit score=0.1041
Hit score=0.2216
Hit score=0.6828
Hit score=0.3285
Hit score=0.1291
Hit score=0.1698
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Homo sapiens
External ID: CHEMBL4029349
Protocol: N/A
Comment: Journal: Drug Discov Today
Year: 2016
Volume: 21
Issue: 4
First Page: 648
Last Page: 653
DOI: 10.1016/j.drudis.2016.02.015

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeStandard RelationStandard Value
DILI_severity_class=3
DILI_severity_class=3
DILI_severity_class=3
DILI_severity_class=8
DILI_severity_class=7
DILI_severity_class=3
DILI_severity_class=0
DILI_severity_class=0
DILI_severity_class=3
DILI_severity_class=5
DILI_severity_class=0
DILI_severity_class=8
DILI_severity_class=8
DILI_severity_class=4
DILI_severity_class=5
DILI_severity_class=0
DILI_severity_class=8
DILI_severity_class=8
DILI_severity_class=5
DILI_severity_class=8
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16
来源:ChEMBL 靶标:Homo sapiens
External ID: CHEMBL4029350
Protocol: N/A
Comment: Journal: Drug Discov Today
Year: 2016
Volume: 21
Issue: 4
First Page: 648
Last Page: 653
DOI: 10.1016/j.drudis.2016.02.015

Target ChEMBL ID: CHEMBL372
ChEMBL Target Name: Homo sapiens
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular
Standard TypeActivity Comment
DILI_ConcernAmbiguous-Dili-Concern
DILI_ConcernLess-Dili-Concern
DILI_ConcernAmbiguous-Dili-Concern
DILI_ConcernMost-Dili-Concern
DILI_ConcernMost-Dili-Concern
DILI_ConcernLess-Dili-Concern
DILI_ConcernLess-Dili-Concern
DILI_ConcernNo-Dili-Concern
DILI_ConcernLess-Dili-Concern
DILI_ConcernAmbiguous-Dili-Concern
DILI_ConcernNo-Dili-Concern
DILI_ConcernMost-Dili-Concern
DILI_ConcernMost-Dili-Concern
DILI_ConcernAmbiguous-Dili-Concern
DILI_ConcernLess-Dili-Concern
DILI_ConcernNo-Dili-Concern
DILI_ConcernMost-Dili-Concern
DILI_ConcernLess-Dili-Concern
DILI_ConcernLess-Dili-Concern
DILI_ConcernMost-Dili-Concern