HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL943598

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2002
Volume: 65
Issue: 12
First Page: 1909
Last Page: 1914
DOI: 10.1021/np020289t

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	20	ug.mL-1
IC50	=	37.5	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	=	25	ug.mL-1
IC50	=	12	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	=	50	ug.mL-1
IC50	=	9	ug.mL-1
IC50	=	0.15	ug.mL-1
IC50	=	30	ug.mL-1
IC50	=	7	ug.mL-1
IC50	=	15	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	=	38	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX12

External ID: CHEMBL924094

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 23
First Page: 7408
Last Page: 7425
DOI: 10.1016/j.bmc.2007.07.036

Target ChEMBL ID: CHEMBL3687
ChEMBL Target Name: Arachidonate 12-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.6	IC50	=	2600	nM
100	IC50	>	100000	nM
0.95	IC50	=	950	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
1.6	IC50	=	1600	nM
7.6	IC50	=	7600	nM
11	IC50	=	11000	nM
1.6	IC50	=	1600	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cryptococcus neoformans

External ID: CHEMBL943600

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2002
Volume: 65
Issue: 12
First Page: 1909
Last Page: 1914
DOI: 10.1021/np020289t

Target ChEMBL ID: CHEMBL365
ChEMBL Target Name: Cryptococcus neoformans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	5.5	ug.mL-1
IC50	=	20	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	=	0.15	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15

External ID: CHEMBL924095

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 23
First Page: 7408
Last Page: 7425
DOI: 10.1016/j.bmc.2007.07.036

Target ChEMBL ID: CHEMBL2903
ChEMBL Target Name: Arachidonate 15-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.25	IC50	=	250	nM
100	IC50	>	100000	nM
1.4	IC50	=	1400	nM
73	IC50	=	73000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
3.3	IC50	=	3300	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
38	IC50	=	38000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
19	IC50	=	19000	nM
0.15	IC50	=	150	nM
0.35	IC50	=	350	nM
7.8	IC50	=	7800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL943599

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2002
Volume: 65
Issue: 12
First Page: 1909
Last Page: 1914
DOI: 10.1021/np020289t

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	=	6	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	=	0.4	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1
IC50	>	50	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_6834_2

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50		4		4000	P05979	BDBM50009859	Prostaglandin G/H synthase 1
IC50		8		8000	P35354	BDBM50009859	Prostaglandin G/H synthase 2
IC50	>	150	>	150000	P05979	BDBM50209568	Prostaglandin G/H synthase 1
IC50	>	150	>	150000	P35354	BDBM50209568	Prostaglandin G/H synthase 2
IC50	>	150	>	150000	P05979	BDBM50222287	Prostaglandin G/H synthase 1
IC50	>	150	>	150000	P35354	BDBM50222287	Prostaglandin G/H synthase 2
IC50	>	50	>	50000	P05979	BDBM106776	Prostaglandin G/H synthase 1
IC50	>	150	>	150000	P35354	BDBM106776	Prostaglandin G/H synthase 2
IC50	>	150	>	150000	P05979	BDBM106787	Prostaglandin G/H synthase 1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1291750

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2010
Volume: 45
Issue: 11
First Page: 5071
Last Page: 5079
DOI: 10.1016/j.ejmech.2010.08.016

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
34	ED50	=	34	uM
29	ED50	=	29	uM
29	ED50	=	29	uM
36	ED50	=	36	uM
105	ED50	=	105	uM
663	ED50	=	663	uM
32	ED50	=	32	uM
63	ED50	=	63	uM
12	ED50	=	12	uM
812	ED50	=	812	uM
26	ED50	=	26	uM
232	ED50	=	232	uM
62	ED50	=	62	uM
23	ED50	=	23	uM
22	ED50	=	22	uM
31	ED50	=	31	uM
56	ED50	=	56	uM
224	ED50	=	224	uM
111	ED50	=	111	uM
46	ED50	=	46	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_6834_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	Standard Relation	PubChem Standard Value	IC50 Qualifier	IC50	Target Accession(s)	Ligand	Target
IC50		0.3		300	P09917	BDBM50139862	Polyunsaturated fatty acid 5-lipoxygenase
IC50		0.9		900	P09917	BDBM50209568	Polyunsaturated fatty acid 5-lipoxygenase
IC50	>	100	>	100000	O15296	BDBM50222284	Polyunsaturated fatty acid lipoxygenase ALOX15B
IC50		0.3		300	P09917	BDBM50222284	Polyunsaturated fatty acid 5-lipoxygenase
IC50	>	100	>	100000	O15296	BDBM50222287	Polyunsaturated fatty acid lipoxygenase ALOX15B
IC50		0.3		300	P09917	BDBM50222290	Polyunsaturated fatty acid 5-lipoxygenase
IC50	>	100	>	100000	O15296	BDBM50222297	Polyunsaturated fatty acid lipoxygenase ALOX15B
IC50	>	30	>	30000	O15296	BDBM106775	Polyunsaturated fatty acid lipoxygenase ALOX15B
IC50		1.5		1500	P09917	BDBM106775	Polyunsaturated fatty acid 5-lipoxygenase
IC50		34		34000	O15296	BDBM106787	Polyunsaturated fatty acid lipoxygenase ALOX15B
IC50		33		33000	O15296	BDBM106788	Polyunsaturated fatty acid lipoxygenase ALOX15B
IC50		0.69		690	P09917	BDBM153381	Polyunsaturated fatty acid 5-lipoxygenase

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15B

External ID: CHEMBL924097

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 23
First Page: 7408
Last Page: 7425
DOI: 10.1016/j.bmc.2007.07.036

Target ChEMBL ID: CHEMBL2457
ChEMBL Target Name: Arachidonate 15-lipoxygenase, type II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
11	IC50	=	11000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
16	IC50	=	16000	nM
100	IC50	>	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Polyunsaturated fatty acid lipoxygenase ALOX15

External ID: CHEMBL924098

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2007
Volume: 15
Issue: 23
First Page: 7408
Last Page: 7425
DOI: 10.1016/j.bmc.2007.07.036

Target ChEMBL ID: CHEMBL2903
ChEMBL Target Name: Arachidonate 15-lipoxygenase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Active
Activity	Active

897-46-1 靶点实验数据