HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL845388

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 4
First Page: 472
Last Page: 477
DOI: 10.1021/jm00154a008

Standard Type	Standard Relation	Standard Value
Ratio	=	4.4
Ratio	=	34
Ratio	=	0.67
Ratio	=	0.89
Ratio	=	0.8
Ratio	=	11
Ratio	=	0.75
Ratio	=	2.2
Ratio	=	11
Ratio	=	23
Ratio	=	2.2
Ratio	=	2.2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCT-8

External ID: CHEMBL685296

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1986
Volume: 29
Issue: 4
First Page: 472
Last Page: 477
DOI: 10.1021/jm00154a008

Target ChEMBL ID: CHEMBL613510
ChEMBL Target Name: HCT-8
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.485	ID50	=	485	nM
0.6	ID50	=	600	nM
0.36	ID50	=	360	nM
0.032	ID50	=	32	nM
0.245	ID50	=	245	nM
0.78	ID50	=	780	nM
0.033	ID50	=	33	nM
0.011	ID50	=	11	nM
0.36	ID50	=	360	nM
0.486	ID50	=	486	nM
0.325	ID50	=	325	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL736470

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 4
First Page: 472
Last Page: 477
DOI: 10.1021/jm00154a008

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
ILS	No activity
ILS	No activity
ILS	No activity
ILS	No activity
ILS	No activity
ILS	No activity

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calf thymus DNA

External ID: CHEMBL665227

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 4
First Page: 472
Last Page: 477
DOI: 10.1021/jm00154a008

Target ChEMBL ID: CHEMBL612514
ChEMBL Target Name: Calf thymus DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value
Log K	=	7.08
Log K	=	7.55
Log K	=	7.31
Log K	=	7.52
Log K	=	7.67
Log K	=	7.85
Log K	=	7.64
Log K	=	7.66
Log K	=	7.35
Log K	=	7.3
Log K	=	7.68
Log K	=	8.44
Log K	=	7.33
Log K	=	7.71
Log K	=	7.21
Log K	=	7.12
Log K	=	7.48
Log K	=	7.23
Log K	=	7.55
Log K	=	7.86

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL739497

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 4
First Page: 472
Last Page: 477
DOI: 10.1021/jm00154a008

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
OD	=	4.5	mg kg-1 day-1
OD	=	8.9	mg kg-1 day-1
OD	=	13.3	mg kg-1 day-1
OD	=	13.3	mg kg-1 day-1
OD	=	13.3	mg kg-1 day-1
OD	=	5.9	mg kg-1 day-1
OD	=	8.9	mg kg-1 day-1
OD	=	20	mg kg-1 day-1
OD	=	2.6	mg kg-1 day-1
OD	=	2.6	mg kg-1 day-1
OD	=	2.6	mg kg-1 day-1
OD	=	45	mg kg-1 day-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L1210

External ID: CHEMBL703181

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1986
Volume: 29
Issue: 4
First Page: 472
Last Page: 477
DOI: 10.1021/jm00154a008

Target ChEMBL ID: CHEMBL386
ChEMBL Target Name: L1210
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.67	ID50	=	670	nM
0.0048	ID50	=	4.8	nM
0.0029	ID50	=	2.9	nM
0.105	ID50	=	105	nM
0.3	ID50	=	300	nM
0.0029	ID50	=	2.9	nM
4.7E-4	ID50	=	0.47	nM
0.25	ID50	=	250	nM
0.22	ID50	=	220	nM
0.3	ID50	=	300	nM

89459-60-9 靶点实验数据