HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL626440

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1481
Last Page: 1485
DOI: 10.1021/jm00377a017

Standard Type	Standard Relation	Standard Value
Rm	=	-1.11
Rm	=	-0.58
Rm	=	-0.89
Rm	=	-1.06
Rm	=	-0.93
Rm	=	-1
Rm	=	-1.18
Rm	=	-0.67
Rm	=	-1.11
Rm	=	-1
Rm	=	-0.73
Rm	=	-1.06

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calf thymus DNA

External ID: CHEMBL666173

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL612514
ChEMBL Target Name: Calf thymus DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Time constant T3	=	80	ms
Time constant T3	=	52	ms
Time constant T3	=	98	ms
Time constant T3	=	44	ms
Time constant T3	=	135	ms
Time constant T3	=	51	ms
Time constant T3	=	86	ms
Time constant T3	=	90	ms
Time constant T3	=	58	ms
Time constant T3	=	49	ms
Time constant T3	=	355	ms
Time constant T3	=	64	ms
Time constant T3	=	311	ms
Time constant T3	=	271	ms
Time constant T3	=	87	ms
Time constant T3	=	168	ms

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calf thymus DNA

External ID: CHEMBL666175

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL612514
ChEMBL Target Name: Calf thymus DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Time constant T4	=	590	ms
Time constant T4	=	280	ms
Time constant T4	=	428	ms
Time constant T4	=	214	ms
Time constant T4	=	2270	ms
Time constant T4	=	330	ms
Time constant T4	=	2050	ms
Time constant T4	=	1000	ms

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calf thymus DNA

External ID: CHEMBL664338

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL612514
ChEMBL Target Name: Calf thymus DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value
Ratio	=	3.4
Ratio	=	2.9
Ratio	=	4.4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL633382

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1481
Last Page: 1485
DOI: 10.1021/jm00377a017

Standard Type	Standard Relation	Standard Value
Log K	=	7.17
Log K	=	7.41
Log K	=	7.49
Log K	=	7.18
Log K	=	7.51
Log K	=	7.29
Log K	=	7.36
Log K	=	7.26
Log K	=	7.35
Log K	=	7.08
Log K	=	7.45
Log K	=	7.34

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL633383

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1481
Last Page: 1485
DOI: 10.1021/jm00377a017

Standard Type	Standard Relation	Standard Value
Log K	=	7.65
Log K	=	7.4
Log K	=	7.43
Log K	=	7.66
Log K	=	7.6
Log K	=	7.58
Log K	=	7.67
Log K	=	7.59
Log K	=	7.7
Log K	=	7.55
Log K	=	7.45
Log K	=	7.73

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L1210

External ID: CHEMBL705270

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL386
ChEMBL Target Name: L1210
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.157	IC50	=	157	nM
1.025	IC50	=	1025	nM
0.0055	IC50	=	5.5	nM
0.015	IC50	=	15	nM
2	IC50	>	2000	nM
1.37	IC50	=	1370	nM
0.077	IC50	=	77	nM
2.6	IC50	=	2600	nM
6.0E-4	IC50	=	0.6	nM
0.67	IC50	=	670	nM
0.0029	IC50	=	2.9	nM
0.015	IC50	=	15	nM
0.3	IC50	=	300	nM
0.0043	IC50	=	4.3	nM
0.22	IC50	=	220	nM
5.3	IC50	=	5300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nucleic Acid

External ID: CHEMBL847170

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL345
ChEMBL Target Name: Nucleic Acid
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value
Log K delta	=	0.01
Log K delta	=	0.06
Log K delta	=	0.48
Log K delta	=	0.09
Log K delta	=	0.29
Log K delta	=	0.33
Log K delta	=	0.35
Log K delta	=	0.47
Log K delta	=	0
Log K delta	=	0.39
Log K delta	=	0.07
Log K delta	=	0.21
Log K delta	=	0.02
Log K delta	=	0.76
Log K delta	=	0.38
Log K delta	=	-0.09
Log K delta	=	-0.18
Log K delta	=	0

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL757193

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
ILS	=	70
ILS	=	98
ILS	=	73
ILS	=	20
ILS	=	27
ILS	=	72

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL721356

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1481
Last Page: 1485
DOI: 10.1021/jm00377a017

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ILS	=	71	%
ILS	=	73	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：P388

External ID: CHEMBL761376

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL389
ChEMBL Target Name: P388
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
OD	=	250	mg kg-1
OD	=	50	mg kg-1
OD	=	30	mg kg-1
OD	=	5.9	mg kg-1
OD	=	4.5	mg kg-1
OD	=	12.5	mg kg-1
OD	=	20	mg kg-1
OD	=	20	mg kg-1
OD	=	8.9	mg kg-1
OD	=	13.3	mg kg-1
OD	=	5.9	mg kg-1
OD	=	8.9	mg kg-1
OD	=	20	mg kg-1
OD	=	45	mg kg-1
OD	=	30	mg kg-1
OD	=	65	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calf thymus DNA

External ID: CHEMBL666167

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL612514
ChEMBL Target Name: Calf thymus DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Time constant T1	=	4	ms
Time constant T1	=	4	ms
Time constant T1	=	6	ms
Time constant T1	=	4	ms
Time constant T1	=	4	ms
Time constant T1	=	3	ms
Time constant T1	=	6	ms
Time constant T1	=	10	ms
Time constant T1	=	4	ms
Time constant T1	=	5	ms
Time constant T1	=	2.5	ms
Time constant T1	=	22	ms
Time constant T1	=	9	ms
Time constant T1	=	20	ms
Time constant T1	=	26	ms
Time constant T1	=	7	ms
Time constant T1	=	6	ms
Time constant T1	=	2	ms
Time constant T1	=	5	ms

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calf thymus DNA

External ID: CHEMBL665230

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL612514
ChEMBL Target Name: Calf thymus DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value
Log K	=	7.41
Log K	=	7.4
Log K	=	7.49
Log K	=	7.43
Log K	=	7.18
Log K	=	7.66
Log K	=	7.51
Log K	=	7.6
Log K	=	7.29
Log K	=	7.58
Log K	=	7.26
Log K	=	7.59
Log K	=	7.35
Log K	=	7.7
Log K	=	7.08
Log K	=	7.55
Log K	=	7.45
Log K	=	7.34
Log K	=	7.73
Log K	=	6.08

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL639040

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1481
Last Page: 1485
DOI: 10.1021/jm00377a017

Standard Type	Standard Relation	Standard Value
pKa	=	6.7
pKa	=	9.1
pKa	=	9.2
pKa	=	8.6
pKa	=	8.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calf thymus DNA

External ID: CHEMBL666171

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 5
First Page: 855
Last Page: 861
DOI: 10.1021/jm00388a019

Target ChEMBL ID: CHEMBL612514
ChEMBL Target Name: Calf thymus DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Time constant T2	=	19	ms
Time constant T2	=	16	ms
Time constant T2	=	27	ms
Time constant T2	=	15	ms
Time constant T2	=	40	ms
Time constant T2	=	13	ms
Time constant T2	=	28	ms
Time constant T2	=	27	ms
Time constant T2	=	16	ms
Time constant T2	=	17	ms
Time constant T2	=	15	ms
Time constant T2	=	102	ms
Time constant T2	=	25	ms
Time constant T2	=	79	ms
Time constant T2	=	83	ms
Time constant T2	=	20	ms
Time constant T2	=	30	ms
Time constant T2	=	11	ms
Time constant T2	=	21	ms

89459-30-3 靶点实验数据