HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Methionine aminopeptidase

External ID: CHEMBL3382364

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL3337333
ChEMBL Target Name: Methionine aminopeptidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Active
	IC50				Not Active
	IC50				Not Active
	IC50				Not Active
26	IC50	=	26000	nM
25	IC50	=	25000	nM
46	IC50	=	46000	nM
32	IC50	=	32000	nM
15	IC50	=	15000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Methionine aminopeptidase

External ID: CHEMBL3382363

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL3423
ChEMBL Target Name: Methionine aminopeptidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
8.4	IC50	=	8400	nM
3.7	IC50	=	3700	nM
3.8	IC50	=	3800	nM
	IC50				Not Active
2.8	IC50	=	2800	nM
3.1	IC50	=	3100	nM
7	IC50	=	7000	nM
1.1	IC50	=	1100	nM
0.7	IC50	=	700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Methionine aminopeptidase 2

External ID: CHEMBL3384242

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL3922
ChEMBL Target Name: Methionine aminopeptidase 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
IC50	Not Active
IC50	Not Active
IC50	Not Active
IC50	Not Active
IC50	Not Active
IC50	Not Active
IC50	Not Active
IC50	Not Active
IC50	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Methionine aminopeptidase 1

External ID: CHEMBL3384241

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL2474
ChEMBL Target Name: Methionine aminopeptidase 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Active
	IC50				Not Active
	IC50				Not Active
	IC50				Not Active
23.4	IC50	=	23400	nM
27	IC50	=	27000	nM
48	IC50	=	48000	nM
43	IC50	=	43000	nM
16.2	IC50	=	16200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL3384243

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	68	%
Inhibition				Not Active
Inhibition				Not Active
Inhibition				Not Active
Inhibition				Not Active
Inhibition	=	90	%
Inhibition	=	50	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3384245

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
t1/2				Not Determined
t1/2				Stable
T1/2	=	5.783	hr
t1/2				Stable
t1/2				Not Determined
t1/2				Not Determined
t1/2				Stable
T1/2	=	0.1667	hr
T1/2	=	0.2667	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glucose transporter

External ID: CHEMBL3436044

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL3431938
ChEMBL Target Name: Glucose transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: St. Jude Childrenâ€™s Research Hospital Leishmania Screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	6.02	%
Inhibition	=	1.08	%
Inhibition	=	3.62	%
Inhibition	=	-0.55	%
Inhibition	=	-2.13	%
Inhibition	=	-1.54	%
Inhibition	=	0.73	%
Inhibition	=	0.63	%
Inhibition	=	-1.34	%
Inhibition	=	2.77	%
Inhibition	=	-5.87	%
Inhibition	=	8.94	%
Inhibition	=	2.88	%
Inhibition	=	0.77	%
Inhibition	=	-0.15	%
Inhibition	=	4.63	%
Inhibition	=	2.43	%
Inhibition	=	-1.72	%
Inhibition	=	-0.85	%
Inhibition	=	2.22	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1

External ID: CHEMBL3436042

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL2535
ChEMBL Target Name: Glucose transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: St. Jude Childrenâ€™s Research Hospital Leishmania Screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	10.68	%
Inhibition	=	3.27	%
Inhibition	=	2.26	%
Inhibition	=	17.48	%
Inhibition	=	1.41	%
Inhibition	=	8.17	%
Inhibition	=	5.47	%
Inhibition	=	2.31	%
Inhibition	=	3.05	%
Inhibition	=	3.73	%
Inhibition	=	5.67	%
Inhibition	=	0.14	%
Inhibition	=	1.93	%
Inhibition	=	16.24	%
Inhibition	=	1.51	%
Inhibition	=	7.91	%
Inhibition	=	6.9	%
Inhibition	=	1.69	%
Inhibition	=	75.77	%
Inhibition	=	96.79	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hexose transporter 1

External ID: CHEMBL3436043

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4697
ChEMBL Target Name: Hexose transporter 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Data Source: St. Jude Childrenâ€™s Research Hospital Leishmania Screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	-1.2	%
Inhibition	=	6.76	%
Inhibition	=	14.6	%
Inhibition	=	0.38	%
Inhibition	=	5.62	%
Inhibition	=	10.22	%
Inhibition	=	1.73	%
Inhibition	=	1.53	%
Inhibition	=	2.85	%
Inhibition	=	0.24	%
Inhibition	=	2.22	%
Inhibition	=	3.5	%
Inhibition	=	4.54	%
Inhibition	=	0.98	%
Inhibition	=	5.18	%
Inhibition	=	-2.18	%
Inhibition	=	1.23	%
Inhibition	=	0.63	%
Inhibition	=	8.47	%
Inhibition	=	1.71	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3384248

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Standard Type	Activity Comment
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Calcium-Dependent Protein Kinase 1 (CDPK1)

External ID: PfalCDPK1

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

CDPK1_IC50_uM
0.103
0.235
0.402
0.798

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HaCaT

External ID: CHEMBL3384247

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL614392
ChEMBL Target Name: HaCaT
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic
Activity	Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3384250

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Protein Kinase 7 (PK7)

External ID: PfalPK7

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

PK7_IC50_uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3384249

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Protein Kinase 6 (PK6)

External ID: PfalPK6

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

PK6_IC50_uM
0.151
0.181
0.229
0.375

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3384252

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：mitogen-activated protein kinase 2 (MAP2 or MAPK2)

External ID: PfalMAPK2

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

ACTIVITY_COMMENT

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3384251

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：1187 靶标：Calcium-Dependent Protein Kinase 4 (CDPK4)

External ID: PfalCDPK4

Protocol: The kinase's catalytic activity was measured with an ATP depletion assay. A luciferase-based reagent, Kinase-Glo, was used to measure the [ATP] remaining after each incubation period.

Comment:

CDPK4_IC50_uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MeWo

External ID: CHEMBL3384254

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL613300
ChEMBL Target Name: MeWo
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3384253

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: MCF7_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, MCF7 is panel number 5, cell number 1. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	88.231	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	87.1119	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.4371	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.7113	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	97.2463	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	90.0129	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.7031	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	30.8539	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.2896	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.8526	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	83.1036	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	84.2194	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.3237	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.6034	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.6643	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	91.2503	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	94.8714	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	93.7372	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	112.6132	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	73.375	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A-431

External ID: CHEMBL3384256

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL614069
ChEMBL Target Name: A-431
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：BT-474

External ID: CHEMBL3384255

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2014
Volume: 24
Issue: 22
First Page: 5310
Last Page: 5314
DOI: 10.1016/j.bmcl.2014.09.047

Target ChEMBL ID: CHEMBL614529
ChEMBL Target Name: BT-474
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: IGROV1_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, IGROV1 is panel number 6, cell number 10. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
0809OS51	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	89.6274	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	94.0185	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	77.1805	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	76.1686	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	82.5618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	88.7561	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	83.5845	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	92.7497	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	70.9555	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	58.7306	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.6041	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	90.3839	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	110.2345	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	97.6538	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	93.7697	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	56.4618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	80.8893	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	79.078	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	-20.3008	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.0949	1	1

879-72-1 靶点实验数据