HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mycolicibacterium smegmatis

External ID: CHEMBL996569

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1983
Volume: 46
Issue: 4
First Page: 493
Last Page: 498
DOI: 10.1021/np50028a012

Target ChEMBL ID: CHEMBL613088
ChEMBL Target Name: Mycolicibacterium smegmatis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	1.56	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HepG2

External ID: CHEMBL833799

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 1
First Page: 163
Last Page: 166
DOI: 10.1016/j.bmcl.2004.10.011

Target ChEMBL ID: CHEMBL395
ChEMBL Target Name: HepG2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
51.8	IC50	=	51800	nM
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
116.8	IC50	=	116800	nM	Outside typical range
103.5	IC50	=	103500	nM	Outside typical range
38	IC50	=	38000	nM
42.1	IC50	=	42100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trichophyton mentagrophytes

External ID: CHEMBL996567

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 493
Last Page: 498
DOI: 10.1021/np50028a012

Target ChEMBL ID: CHEMBL613162
ChEMBL Target Name: Trichophyton mentagrophytes
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	1.56	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL996568

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 493
Last Page: 498
DOI: 10.1021/np50028a012

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.12	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saccharomyces cerevisiae

External ID: CHEMBL996566

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1983
Volume: 46
Issue: 4
First Page: 493
Last Page: 498
DOI: 10.1021/np50028a012

Target ChEMBL ID: CHEMBL361
ChEMBL Target Name: Saccharomyces cerevisiae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2350958

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 7
First Page: 2238
Last Page: 2244
DOI: 10.1016/j.bmcl.2013.01.046

Standard Type	Standard Relation	Standard Value
Ratio CC50/IC50	=	2.77
Ratio CC50/IC50	=	31.37
Ratio CC50/IC50	=	18.91
Ratio CC50/IC50	=	35.28
Ratio CC50/IC50	=	1.84
Ratio CC50/IC50	=	1.23

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2350957

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 7
First Page: 2238
Last Page: 2244
DOI: 10.1016/j.bmcl.2013.01.046

Standard Type	Standard Relation	Standard Value
Ratio CC50/IC50	=	2.22
Ratio CC50/IC50	=	16.94
Ratio CC50/IC50	=	22.14
Ratio CC50/IC50	=	8.82
Ratio CC50/IC50	=	4.83
Ratio CC50/IC50	=	6.63

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4350054

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2019
Volume: 27
Issue: 16
First Page: 3729
Last Page: 3734
DOI: 10.1016/j.bmc.2019.06.042

Standard Type	Standard Relation	Standard Value
LogP	=	5
LogP	=	5.07
LogP	=	5.28
LogP	=	5.35
LogP	=	5.97
LogP	=	4.8
LogP	=	4.82
LogP	=	3.2
LogP	=	5.35
LogP	=	5.36
LogP	=	4.75
LogP	=	5.21
LogP	=	5.38
LogP	=	5.8
LogP	=	6.97
LogP	=	6.74

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepatitis B virus

External ID: CHEMBL2350956

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 7
First Page: 2238
Last Page: 2244
DOI: 10.1016/j.bmcl.2013.01.046

Target ChEMBL ID: CHEMBL613497
ChEMBL Target Name: Hepatitis B virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1000	IC50	>	1000000	nM	Outside typical range
14.67	IC50	=	14670	nM
41.38	IC50	=	41380	nM
12.23	IC50	=	12230	nM
30.24	IC50	=	30240	nM
10.49	IC50	=	10490	nM
147.16	IC50	=	147160	nM	Outside typical range
26.74	IC50	=	26740	nM
1000	IC50	>	1000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepatitis B virus

External ID: CHEMBL2350955

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 7
First Page: 2238
Last Page: 2244
DOI: 10.1016/j.bmcl.2013.01.046

Target ChEMBL ID: CHEMBL613497
ChEMBL Target Name: Hepatitis B virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1000	IC50	>	1000000	nM	Outside typical range
12.72	IC50	=	12720	nM
1000	IC50	>	1000000	nM	Outside typical range
27.55	IC50	=	27550	nM
1000	IC50	>	1000000	nM	Outside typical range
61.22	IC50	=	61220	nM
1000	IC50	>	1000000	nM	Outside typical range
17.68	IC50	=	17680	nM
1000	IC50	>	1000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hepatitis B virus

External ID: CHEMBL2350960

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 7
First Page: 2238
Last Page: 2244
DOI: 10.1016/j.bmcl.2013.01.046

Target ChEMBL ID: CHEMBL613497
ChEMBL Target Name: Hepatitis B virus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1000	IC50	>	1000000	nM	Outside typical range
3.67	IC50	=	3670	nM
108.57	IC50	=	108570	nM	Outside typical range
15.67	IC50	=	15670	nM
162.43	IC50	=	162430	nM	Outside typical range
12.18	IC50	=	12180	nM
1000	IC50	>	1000000	nM	Outside typical range
6.98	IC50	=	6980	nM
1000	IC50	>	1000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2350959

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 7
First Page: 2238
Last Page: 2244
DOI: 10.1016/j.bmcl.2013.01.046

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
180.07	CC50	=	180070	nM
129.46	CC50	=	129460	nM
200	CC50	=	200000	nM
180.23	CC50	=	180230	nM
200.57	CC50	=	200570	nM
200.43	CC50	=	200430	nM
200.07	CC50	=	200070	nM
210.46	CC50	=	210460	nM
190.03	CC50	=	190030	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2350954

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 7
First Page: 2238
Last Page: 2244
DOI: 10.1016/j.bmcl.2013.01.046

Standard Type	Standard Relation	Standard Value
Ratio CC50/IC50	=	3.93
Ratio CC50/IC50	=	7.34
Ratio CC50/IC50	=	15.13
Ratio CC50/IC50	=	10.18

87688-90-2 靶点实验数据