HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen phosphorylase, muscle form

External ID: CHEMBL1799389

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2011
Volume: 46
Issue: 6
First Page: 2011
Last Page: 2021
DOI: 10.1016/j.ejmech.2011.02.053

Target ChEMBL ID: CHEMBL4696
ChEMBL Target Name: Glycogen phosphorylase, muscle form
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
16.9824	IC50	=	16982.44	nM
14.1254	IC50	=	14125.38	nM
14	IC50	=	14000	nM
8.91251	IC50	=	8912.51	nM
9	IC50	=	9000	nM
19.0546	IC50	=	19054.61	nM
19	IC50	=	19000	nM
66	IC50	=	66000	nM
50	IC50	=	50000	nM
66	IC50	=	66000	nM
7	IC50	=	7000	nM
151.356	IC50	=	151356.12	nM	Outside typical range
30.1995	IC50	=	30199.52	nM
31	IC50	=	31000	nM
162.181	IC50	=	162181.01	nM	Outside typical range
31.8	IC50	=	31800	nM
31.6228	IC50	=	31622.78	nM
41.2	IC50	=	41200	nM
7.24436	IC50	=	7244.36	nM
107.9	IC50	=	107900	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866596

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2016
Volume: 122
First Page: 452
Last Page: 464
DOI: 10.1016/j.ejmech.2016.06.053

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.9	EC50	=	2900	nM
2.4	EC50	=	2400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866597

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2016
Volume: 122
First Page: 452
Last Page: 464
DOI: 10.1016/j.ejmech.2016.06.053

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.3	EC50	=	6300	nM
4.1	EC50	=	4100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866598

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2016
Volume: 122
First Page: 452
Last Page: 464
DOI: 10.1016/j.ejmech.2016.06.053

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
9.3	EC50	=	9300	nM
4.3	EC50	=	4300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL898956

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 21
First Page: 5777
Last Page: 5782
DOI: 10.1016/j.bmcl.2007.08.057

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
115.5	IC50	=	115500	nM		Outside typical range
31.8	IC50	=	31800	nM
41.2	IC50	=	41200	nM
323.5	IC50	=	323500	nM		Outside typical range
107.9	IC50	=	107900	nM		Outside typical range
92.1	IC50	=	92100	nM
62.1	IC50	=	62100	nM
78.7	IC50	=	78700	nM
	Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866599

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2016
Volume: 122
First Page: 452
Last Page: 464
DOI: 10.1016/j.ejmech.2016.06.053

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
7.4	EC50	=	7400	nM
4.2	EC50	=	4200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866600

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2016
Volume: 122
First Page: 452
Last Page: 464
DOI: 10.1016/j.ejmech.2016.06.053

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
2.2	EC50	=	2200	nM
2	EC50	=	2000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3866601

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2016
Volume: 122
First Page: 452
Last Page: 464
DOI: 10.1016/j.ejmech.2016.06.053

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
5	EC50	=	5000	nM
3.4	EC50	=	3400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Glycogen phosphorylase, muscle form

External ID: CHEMBL961425

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2008
Volume: 51
Issue: 12
First Page: 3540
Last Page: 3554
DOI: 10.1021/jm8000949

Target ChEMBL ID: CHEMBL4696
ChEMBL Target Name: Glycogen phosphorylase, muscle form
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
14	IC50	=	14000	nM
9	IC50	=	9000	nM
28	IC50	=	28000	nM
144	IC50	=	144000	nM		Outside typical range
66	IC50	=	66000	nM
20	IC50	=	20000	nM
213	IC50	=	213000	nM		Outside typical range
116	IC50	=	116000	nM		Outside typical range
106	IC50	=	106000	nM		Outside typical range
16	IC50	=	16000	nM
17	IC50	=	17000	nM
18	IC50	=	18000	nM
21	IC50	=	21000	nM
	Activity				Not Active
57	IC50	=	57000	nM
19	IC50	=	19000	nM
34	IC50	=	34000	nM
82	IC50	=	82000	nM
293	IC50	=	293000	nM		Outside typical range
97	IC50	=	97000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL3866602

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2016
Volume: 122
First Page: 452
Last Page: 464
DOI: 10.1016/j.ejmech.2016.06.053

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.9	EC50	=	900	nM
2.9	EC50	=	2900	nM

87205-98-9 靶点实验数据