HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cathepsin L2

External ID: CHEMBL1670879

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 4
First Page: 1477
Last Page: 1481
DOI: 10.1016/j.bmc.2010.12.056

Target ChEMBL ID: CHEMBL3272
ChEMBL Target Name: Cathepsin L2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.9	IC50	=	3900	nM
2.2	IC50	=	2200	nM
2.5	IC50	=	2500	nM
2.8	IC50	=	2800	nM
44	IC50	=	44000	nM
25	IC50	=	25000	nM
1.2	IC50	=	1200	nM
5.2	IC50	=	5200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cathepsin L2

External ID: CHEMBL1670880

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 4
First Page: 1477
Last Page: 1481
DOI: 10.1016/j.bmc.2010.12.056

Target ChEMBL ID: CHEMBL3272
ChEMBL Target Name: Cathepsin L2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.1	Ki	=	1100	nM
0.5	Ki	=	500	nM
1.7	Ki	=	1700	nM
10	Ki	=	10000	nM
0.2	Ki	=	200	nM
4.4	Ki	=	4400	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：CCRF-HSB-2

External ID: CHEMBL969084

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1999
Volume: 62
Issue: 4
First Page: 587
Last Page: 589
DOI: 10.1021/np980504z

Target ChEMBL ID: CHEMBL614541
ChEMBL Target Name: CCRF-HSB-2
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
5.41	IC50	=	5410	nM
2.5	IC50	=	2500	nM
29.2	IC50	=	29200	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
3.1	IC50	=	3100	nM
40	IC50	>	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：B16

External ID: CHEMBL969083

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1999
Volume: 62
Issue: 4
First Page: 587
Last Page: 589
DOI: 10.1021/np980504z

Target ChEMBL ID: CHEMBL381
ChEMBL Target Name: B16
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
8.04	IC50	=	8040	nM
4.63	IC50	=	4630	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
5.05	IC50	=	5050	nM
40	IC50	>	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：TGBC11TKB

External ID: CHEMBL969085

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1999
Volume: 62
Issue: 4
First Page: 587
Last Page: 589
DOI: 10.1021/np980504z

Target ChEMBL ID: CHEMBL2366374
ChEMBL Target Name: TGBC11TKB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
2.13	IC50	=	2130	nM
1.43	IC50	=	1430	nM
19.3	IC50	=	19300	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
2.07	IC50	=	2070	nM
40	IC50	>	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：COLO 205

External ID: CHEMBL947726

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2001
Volume: 64
Issue: 8
First Page: 1040
Last Page: 1043
DOI: 10.1021/np0005309

Target ChEMBL ID: CHEMBL614561
ChEMBL Target Name: COLO 205
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	6.3	ug ml-1
ED50	=	1.2	ug ml-1
ED50	=	0.58	ug ml-1
ED50				Not Active
ED50				Not Active
ED50				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL969082

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 1999
Volume: 62
Issue: 4
First Page: 587
Last Page: 589
DOI: 10.1021/np980504z

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	>	40000	nM
9.37	IC50	=	9370	nM
6.26	IC50	=	6260	nM
24.4	IC50	=	24400	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
40	IC50	>	40000	nM
6.37	IC50	=	6370	nM
40	IC50	>	40000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL947728

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2001
Volume: 64
Issue: 8
First Page: 1040
Last Page: 1043
DOI: 10.1021/np0005309

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	0.09	ug ml-1
ED50				Not Active
ED50				Not Active
ED50	=	0.22	ug ml-1
ED50	=	0.09	ug ml-1
ED50	=	0.82	ug ml-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL947727

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 2001
Volume: 64
Issue: 8
First Page: 1040
Last Page: 1043
DOI: 10.1021/np0005309

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	6.6	ug ml-1
ED50				Not Active
ED50				Not Active
ED50	=	5.3	ug ml-1
ED50				Not Active
ED50				Not Active

86680-32-2 靶点实验数据