HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cricetinae gen. sp.

External ID: CHEMBL692220

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1516
Last Page: 1531
DOI: 10.1021/jm00377a022

Target ChEMBL ID: CHEMBL612361
ChEMBL Target Name: Cricetinae gen. sp.
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	17	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ornithine decarboxylase

External ID: CHEMBL753501

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 11
First Page: 1653
Last Page: 1656
DOI: 10.1021/jm00365a021

Target ChEMBL ID: CHEMBL2840
ChEMBL Target Name: Ornithine decarboxylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	80	%
Inhibition	=	48	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cricetinae gen. sp.

External ID: CHEMBL686689

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1516
Last Page: 1531
DOI: 10.1021/jm00377a022

Target ChEMBL ID: CHEMBL612361
ChEMBL Target Name: Cricetinae gen. sp.
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ornithine decarboxylase

External ID: CHEMBL753500

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 11
First Page: 1653
Last Page: 1656
DOI: 10.1021/jm00365a021

Target ChEMBL ID: CHEMBL2840
ChEMBL Target Name: Ornithine decarboxylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	56	%
Inhibition	=	30	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor alpha

External ID: CHEMBL799802

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 26
First Page: 4993
Last Page: 5006
DOI: 10.1021/jm00026a006

Target ChEMBL ID: CHEMBL2055
ChEMBL Target Name: Retinoic acid receptor alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0053	Ki	=	5.3	nM
10	Ki	>	10000	nM
0.13	Ki	=	130	nM
6.5	Ki	=	6500	nM
10	Ki	>	10000	nM
0.834	Ki	=	834	nM
6.5	Ki	=	6500	nM
10	Ki	>	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor beta

External ID: CHEMBL798918

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 17
First Page: 2289
Last Page: 2294
DOI: 10.1016/S0960-894X(97)00405-8

Target ChEMBL ID: CHEMBL2008
ChEMBL Target Name: Retinoic acid receptor beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.036	Ki	=	36	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor beta

External ID: CHEMBL798917

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 26
First Page: 4993
Last Page: 5006
DOI: 10.1021/jm00026a006

Target ChEMBL ID: CHEMBL2008
ChEMBL Target Name: Retinoic acid receptor beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.003	Ki	=	3	nM
3.55	Ki	=	3550	nM
0.012	Ki	=	12	nM
2.48	Ki	=	2480	nM
0.288	Ki	=	288	nM
0.105	Ki	=	105	nM
0.036	Ki	=	36	nM
0.156	Ki	=	156	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor alpha

External ID: CHEMBL799803

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 17
First Page: 2289
Last Page: 2294
DOI: 10.1016/S0960-894X(97)00405-8

Target ChEMBL ID: CHEMBL2055
ChEMBL Target Name: Retinoic acid receptor alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.487	Ki	=	487	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor gamma

External ID: CHEMBL798023

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 17
First Page: 2289
Last Page: 2294
DOI: 10.1016/S0960-894X(97)00405-8

Target ChEMBL ID: CHEMBL2003
ChEMBL Target Name: Retinoic acid receptor gamma
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.019	Ki	=	19	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor gamma

External ID: CHEMBL798022

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 26
First Page: 4993
Last Page: 5006
DOI: 10.1021/jm00026a006

Target ChEMBL ID: CHEMBL2003
ChEMBL Target Name: Retinoic acid receptor gamma
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.002	Ki	=	2	nM
0.2	Ki	=	200	nM
0.013	Ki	=	13	nM
0.077	Ki	=	77	nM
0.153	Ki	=	153	nM
0.085	Ki	=	85	nM
0.426	Ki	=	426	nM
0.386	Ki	=	386	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor alpha

External ID: CHEMBL801812

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 12
First Page: 1311
Last Page: 1313
DOI: 10.1016/s0960-894x(00)00244-4

Target ChEMBL ID: CHEMBL2055
ChEMBL Target Name: Retinoic acid receptor alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1	AC50	>	1000	nM
0.079	AC50	=	79	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL813542

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
7.0E-6	ID50	=	0.007	nM
8.0E-5	ID50	=	0.08	nM
0.01	ID50	>	10	nM
1.0E-4	ID50	>	0.1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ornithine decarboxylase

External ID: CHEMBL751945

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

Target ChEMBL ID: CHEMBL3511
ChEMBL Target Name: Ornithine decarboxylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
3.0E-5	ID50	=	0.03	nM
0.066	ID50	=	66	nM
0.142	ID50	=	142	nM
0.0032	ID50	=	3.2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor beta

External ID: CHEMBL799126

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 12
First Page: 1311
Last Page: 1313
DOI: 10.1016/s0960-894x(00)00244-4

Target ChEMBL ID: CHEMBL2008
ChEMBL Target Name: Retinoic acid receptor beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activation	=	86	%
Activation	=	82	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor beta

External ID: CHEMBL795952

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 12
First Page: 1311
Last Page: 1313
DOI: 10.1016/s0960-894x(00)00244-4

Target ChEMBL ID: CHEMBL2008
ChEMBL Target Name: Retinoic acid receptor beta
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1	AC50	>	1000	nM
0.001	AC50	<	1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor gamma

External ID: CHEMBL801575

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 12
First Page: 1311
Last Page: 1313
DOI: 10.1016/s0960-894x(00)00244-4

Target ChEMBL ID: CHEMBL2003
ChEMBL Target Name: Retinoic acid receptor gamma
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activation	=	75	%
Activation	=	95	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL852218

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 11
First Page: 1653
Last Page: 1656
DOI: 10.1021/jm00365a021

Standard Type	Standard Relation	Standard Value
Ratio	>	10

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha

External ID: CHEMBL769013

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 12
First Page: 1311
Last Page: 1313
DOI: 10.1016/s0960-894x(00)00244-4

Target ChEMBL ID: CHEMBL2061
ChEMBL Target Name: Retinoid X receptor alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1	AC50	>	1000	nM
0.135	AC50	=	135	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cellular retinoic acid-binding protein 1

External ID: CHEMBL662929

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

Target ChEMBL ID: CHEMBL4945
ChEMBL Target Name: Cellular retinoic acid-binding protein I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1	ID50	=	1	uM
4.8	ID50	=	4.8	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL771912

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Control	=	5	%
Control	=	1	%
Control	=	2	%
Control	=	1	%
Control	=	2	%
Control	=	2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha

External ID: CHEMBL769017

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 12
First Page: 1311
Last Page: 1313
DOI: 10.1016/s0960-894x(00)00244-4

Target ChEMBL ID: CHEMBL2061
ChEMBL Target Name: Retinoid X receptor alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activation	=	0	%
Activation	=	0	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL662933

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Control	=	100	%
Control	=	91	%
Control	=	27	%
Control				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cricetinae gen. sp.

External ID: CHEMBL692452

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 11
First Page: 1653
Last Page: 1656
DOI: 10.1021/jm00365a021

Target ChEMBL ID: CHEMBL612361
ChEMBL Target Name: Cricetinae gen. sp.
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Active culture	=	7	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL814459

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

Standard Type	Standard Relation	Standard Value	Standard Units
Control	=	15	%
Control	=	1	%
Control	=	9	%
Control	=	5	%
Control	=	11	%
Control	=	14	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL771911

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Control	=	100	%
Control	=	6	%
Control	=	15	%
Control	=	2	%
Control	=	12	%
Control	=	13	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：F9

External ID: CHEMBL679217

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1995
Volume: 38
Issue: 26
First Page: 4993
Last Page: 5006
DOI: 10.1021/jm00026a006

Target ChEMBL ID: CHEMBL614296
ChEMBL Target Name: F9
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
4.6E-4	AC50	=	0.46	nM
0.03	AC50	=	30	nM
0.033	AC50	=	33	nM
0.0075	AC50	=	7.5	nM
0.073	AC50	=	73	nM
0.3	AC50	=	300	nM
0.03	AC50	=	30	nM
0.46	AC50	=	460	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Oryctolagus cuniculus

External ID: CHEMBL771916

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

Target ChEMBL ID: CHEMBL374
ChEMBL Target Name: Oryctolagus cuniculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Control	<	1	%
Control	<	1	%
Control	<	1	%
Control	=	0	%
Control	<	1	%
Control	<	1	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cricetinae gen. sp.

External ID: CHEMBL692485

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 11
First Page: 1653
Last Page: 1656
DOI: 10.1021/jm00365a021

Target ChEMBL ID: CHEMBL612361
ChEMBL Target Name: Cricetinae gen. sp.
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Active culture	=	21	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor RXR-alpha

External ID: CHEMBL842288

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 17
First Page: 2289
Last Page: 2294
DOI: 10.1016/S0960-894X(97)00405-8

Target ChEMBL ID: CHEMBL2061
ChEMBL Target Name: Retinoid X receptor alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cricetinae gen. sp.

External ID: CHEMBL692486

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 11
First Page: 1653
Last Page: 1656
DOI: 10.1021/jm00365a021

Target ChEMBL ID: CHEMBL612361
ChEMBL Target Name: Cricetinae gen. sp.
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Active culture	=	17	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cricetinae gen. sp.

External ID: CHEMBL689209

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1516
Last Page: 1531
DOI: 10.1021/jm00377a022

Target ChEMBL ID: CHEMBL612361
ChEMBL Target Name: Cricetinae gen. sp.
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	21	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：F9

External ID: CHEMBL677727

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 1997
Volume: 7
Issue: 17
First Page: 2289
Last Page: 2294
DOI: 10.1016/S0960-894X(97)00405-8

Target ChEMBL ID: CHEMBL614296
ChEMBL Target Name: F9
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.3	AC50	=	300	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cricetinae gen. sp.

External ID: CHEMBL692488

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 11
First Page: 1653
Last Page: 1656
DOI: 10.1021/jm00365a021

Target ChEMBL ID: CHEMBL612361
ChEMBL Target Name: Cricetinae gen. sp.
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Active culture	=	4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：F9

External ID: CHEMBL677730

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

Target ChEMBL ID: CHEMBL614296
ChEMBL Target Name: F9
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0015	ED50	=	1.5	nM
5	ED50	>	5000	nM
0.1	ED50	>	100	nM
0.09	ED50	=	90	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：F9

External ID: CHEMBL677729

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 1989
Volume: 32
Issue: 7
First Page: 1504
Last Page: 1517
DOI: 10.1021/jm00127a018

Target ChEMBL ID: CHEMBL614296
ChEMBL Target Name: F9
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
7.0E-4	ED50	=	0.7	nM
0.003	ED50	=	3	nM
0.01	ED50	>	10	nM
0.002	ED50	=	2	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor alpha

External ID: CHEMBL802580

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 12
First Page: 1311
Last Page: 1313
DOI: 10.1016/s0960-894x(00)00244-4

Target ChEMBL ID: CHEMBL2055
ChEMBL Target Name: Retinoic acid receptor alpha
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Activation	=	85	%
Activation	=	23	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cricetinae gen. sp.

External ID: CHEMBL690255

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1984
Volume: 27
Issue: 11
First Page: 1516
Last Page: 1531
DOI: 10.1021/jm00377a022

Target ChEMBL ID: CHEMBL612361
ChEMBL Target Name: Cricetinae gen. sp.
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
ED50	=	0
ED50	=	0
ED50	=	0
ED50	=	0
ED50	=	0
ED50	=	0
ED50	=	0
ED50	>	1.0E-8

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trachea

External ID: CHEMBL904908

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 11
First Page: 2622
Last Page: 2639
DOI: 10.1021/jm0613323

Target ChEMBL ID: CHEMBL613452
ChEMBL Target Name: Trachea
ChEMBL Target Type: TISSUE - Target is a healthy or diseased tissue
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	IC50				Not Determined
3.2E-4	IC50	=	0.32	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：F9

External ID: CHEMBL904909

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2007
Volume: 50
Issue: 11
First Page: 2622
Last Page: 2639
DOI: 10.1021/jm0613323

Target ChEMBL ID: CHEMBL614296
ChEMBL Target Name: F9
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Determined
3.0E-4	IC50	=	0.3	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL904910

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2007
Volume: 50
Issue: 11
First Page: 2622
Last Page: 2639
DOI: 10.1021/jm0613323

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ID50	=	0.19	nmol
ID50	=	2	nmol
ID50	=	66	nmol

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Retinoic acid receptor gamma

External ID: CHEMBL618435

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 12
First Page: 1311
Last Page: 1313
DOI: 10.1016/s0960-894x(00)00244-4

Target ChEMBL ID: CHEMBL2003
ChEMBL Target Name: Retinoic acid receptor gamma
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1	AC50	=	1000	nM
0.001	AC50	<	1	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ornithine decarboxylase

External ID: CHEMBL755446

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1516
Last Page: 1531
DOI: 10.1021/jm00377a022

Target ChEMBL ID: CHEMBL2840
ChEMBL Target Name: Ornithine decarboxylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	88	%
Inhibition	=	42	%
Inhibition	=	56	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ornithine decarboxylase

External ID: CHEMBL755447

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1984
Volume: 27
Issue: 11
First Page: 1516
Last Page: 1531
DOI: 10.1021/jm00377a022

Target ChEMBL ID: CHEMBL2840
ChEMBL Target Name: Ornithine decarboxylase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	81	%
Inhibition	=	80	%

86471-16-1 靶点实验数据