HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：DU-145

External ID: CHEMBL5242175

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2021
Volume: 224
First Page: 113688
Last Page: 113688
DOI: 10.1016/j.ejmech.2021.113688

Target ChEMBL ID: CHEMBL613508
ChEMBL Target Name: DU-145
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	9.43	ug.mL-1
IC50	=	1.58	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HCC1395

External ID: CHEMBL5242174

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2021
Volume: 224
First Page: 113688
Last Page: 113688
DOI: 10.1016/j.ejmech.2021.113688

Target ChEMBL ID: CHEMBL1075454
ChEMBL Target Name: HCC1395
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IC50	=	8.12	ug.mL-1
IC50	=	14.7	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL3223920

Protocol: N/A

Comment: Journal: MedChemComm
Year: 2012
Volume: 3
Issue: 7
First Page: 771
Last Page: 774
DOI: 10.1039/C2MD20047C

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	40	%
Activity				Not Active
Activity	=	40	%
Activity				Not Active
Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trichophyton mentagrophytes

External ID: CHEMBL1008658

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2005
Volume: 68
Issue: 11
First Page: 1581
Last Page: 1587
DOI: 10.1021/np050250z

Target ChEMBL ID: CHEMBL613162
ChEMBL Target Name: Trichophyton mentagrophytes
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
6.3	MIC	=	6300	nM
	MIC				Not Determined
200	MIC	>	200000	nM
200	MIC	>	200000	nM
106	MIC	=	106000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL4235765

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 18
First Page: 3123
Last Page: 3128
DOI: 10.1016/j.bmcl.2018.06.001

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	64	ug.mL-1
MIC	=	1	ug.mL-1
MIC	>	64	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	16	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	8	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus fumigatus

External ID: CHEMBL1008659

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2005
Volume: 68
Issue: 11
First Page: 1581
Last Page: 1587
DOI: 10.1021/np050250z

Target ChEMBL ID: CHEMBL363
ChEMBL Target Name: Aspergillus fumigatus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	MIC	=	50000	nM
200	MIC	>	200000	nM
200	MIC	>	200000	nM
200	MIC	>	200000	nM
200	MIC	>	200000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cryptococcus neoformans

External ID: CHEMBL1008656

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Nat Prod
Year: 2005
Volume: 68
Issue: 11
First Page: 1581
Last Page: 1587
DOI: 10.1021/np050250z

Target ChEMBL ID: CHEMBL365
ChEMBL Target Name: Cryptococcus neoformans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	MIC	=	50000	nM
200	MIC	>	200000	nM
200	MIC	>	200000	nM
200	MIC	>	200000	nM
106	MIC	=	106000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saccharomyces cerevisiae

External ID: CHEMBL1008657

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2005
Volume: 68
Issue: 11
First Page: 1581
Last Page: 1587
DOI: 10.1021/np050250z

Target ChEMBL ID: CHEMBL361
ChEMBL Target Name: Saccharomyces cerevisiae
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	MIC	=	50000	nM
200	MIC	>	200000	nM
124	MIC	=	124000	nM
7.7	MIC	=	7700	nM
53.2	MIC	=	53200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL1008655

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Nat. Prod.
Year: 2005
Volume: 68
Issue: 11
First Page: 1581
Last Page: 1587
DOI: 10.1021/np050250z

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
200	MIC	>	200000	nM
146	MIC	=	146000	nM
124	MIC	=	124000	nM
200	MIC	>	200000	nM
53.2	MIC	=	53200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Calf thymus DNA

External ID: CHEMBL947536

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1991
Volume: 54
Issue: 6
First Page: 1522
Last Page: 1530
DOI: 10.1021/np50078a006

Target ChEMBL ID: CHEMBL612514
ChEMBL Target Name: Calf thymus DNA
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Evaluated
Activity				Not Evaluated
Activity	<	30	%
Activity	>	70	%
Activity	=	100	%
Activity	<	30	%
Activity	=	100	%
Activity	>	70	%
Activity	>	70	%
Activity	=	100	%
Activity	<	30	%
Activity	=	30	%
Activity				Not Evaluated
Activity	=	30	%
Activity				Not Evaluated
Activity				Not Evaluated
Activity	=	30	%
Activity	=	100	%
Activity	>	70	%
Activity				Not Evaluated

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nucleic Acid

External ID: CHEMBL947537

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 1991
Volume: 54
Issue: 6
First Page: 1522
Last Page: 1530
DOI: 10.1021/np50078a006

Target ChEMBL ID: CHEMBL345
ChEMBL Target Name: Nucleic Acid
ChEMBL Target Type: NUCLEIC-ACID - Target is DNA, RNA or PNA
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity				Not Evaluated
Activity				Not Evaluated
Activity	<	30	%
Activity	=	30	%
Activity	=	100	%
Activity				Not Determined
Activity	=	100	%
Activity	=	100	%
Activity	=	100	%
Activity				Not Determined
Activity	>	70	%
Activity	<	30	%
Activity				Not Determined
Activity				Not Determined
Activity				Not Evaluated
Activity				Not Determined
Activity				Not Determined
Activity	=	100	%
Activity	=	100	%
Activity				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus cereus

External ID: CHEMBL4235767

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 18
First Page: 3123
Last Page: 3128
DOI: 10.1016/j.bmcl.2018.06.001

Target ChEMBL ID: CHEMBL613070
ChEMBL Target Name: Bacillus cereus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	64	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	4	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	4	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	16	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL4235766

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 18
First Page: 3123
Last Page: 3128
DOI: 10.1016/j.bmcl.2018.06.001

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	64	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	64	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	8	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	4	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ralstonia solanacearum

External ID: CHEMBL4235769

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 18
First Page: 3123
Last Page: 3128
DOI: 10.1016/j.bmcl.2018.06.001

Target ChEMBL ID: CHEMBL612602
ChEMBL Target Name: Ralstonia solanacearum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	64	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	16	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	8	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	8	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL995696

Protocol: N/A

Comment: Journal: J Nat Prod
Year: 1983
Volume: 46
Issue: 2
First Page: 222
Last Page: 225
DOI: 10.1021/np50026a016

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
ED50	=	2.1	ug ml-1
ED50	=	2.2	ug ml-1
Activity				Not Active
Activity				Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL4235768

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2018
Volume: 28
Issue: 18
First Page: 3123
Last Page: 3128
DOI: 10.1016/j.bmcl.2018.06.001

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	>	64	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	8	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	2	ug.mL-1
MIC	>	64	ug.mL-1
MIC	=	4	ug.mL-1

86293-40-5 靶点实验数据