HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ishikawa

External ID: CHEMBL889117

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 13
First Page: 3544
Last Page: 3549
DOI: 10.1016/j.bmcl.2007.04.044

Target ChEMBL ID: CHEMBL614649
ChEMBL Target Name: Ishikawa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
	Efficacy	=	95	%
0.0049	IC50	=	4.9	nM
	Efficacy	=	96	%
0.0185	IC50	=	18.5	nM
	Efficacy	=	94	%
0.0021	IC50	=	2.1	nM
	Efficacy	=	93	%
0.008	IC50	=	8	nM
	Efficacy	=	95	%
0.0145	IC50	=	14.5	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Ishikawa

External ID: CHEMBL889120

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 13
First Page: 3544
Last Page: 3549
DOI: 10.1016/j.bmcl.2007.04.044

Target ChEMBL ID: CHEMBL614649
ChEMBL Target Name: Ishikawa
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Efficacy	=	29	%
Efficacy	=	19	%
Efficacy	=	11	%
Efficacy	=	19	%
Efficacy	=	24	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL889121

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 13
First Page: 3544
Last Page: 3549
DOI: 10.1016/j.bmcl.2007.04.044

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.071	mg.kg-1
ED50	=	0.14	mg.kg-1
ED50	=	0.37	mg.kg-1
ED50	=	0.25	mg.kg-1
ED50	=	0.26	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL889127

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 13
First Page: 3544
Last Page: 3549
DOI: 10.1016/j.bmcl.2007.04.044

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Ratio	=	1.1
Ratio	=	1.75
Ratio	=	1.06
Ratio	=	8.64
Ratio	=	1.94

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL889126

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2007
Volume: 17
Issue: 13
First Page: 3544
Last Page: 3549
DOI: 10.1016/j.bmcl.2007.04.044

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	<	1	mg.kg-1
Inhibition	=	83	%
ED50	<	1	mg.kg-1
Inhibition	=	83	%
ED50	<	1	mg.kg-1
Inhibition	=	83	%
ED50	<	1	mg.kg-1
Inhibition	=	83	%
ED50	<	1	mg.kg-1
Inhibition	=	83	%

862129-77-9 靶点实验数据