HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Isocitrate lyase

External ID: CHEMBL1764546

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL5359
ChEMBL Target Name: Isocitrate lyase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
IC50				Not Determined
IC50	=	4.2	ug.mL-1
IC50	=	63.4	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	=	48.4	ug.mL-1
IC50	=	71	ug.mL-1		Outside typical range
IC50	>	200	ug.mL-1		Outside typical range
IC50	=	60.8	ug.mL-1		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1764545

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
43.6	IC50	=	43600	nM
83.1	IC50	=	83100	nM
3.6	IC50	=	3600	nM
14	IC50	=	14000	nM
6	IC50	=	6000	nM
24.4	IC50	=	24400	nM
4.6	IC50	=	4600	nM
60.6	IC50	=	60600	nM
20.2	IC50	=	20200	nM
30.5	IC50	=	30500	nM
7	IC50	=	7000	nM
144.6	IC50	=	144600	nM	Outside typical range
45	IC50	=	45000	nM
125.6	IC50	=	125600	nM	Outside typical range
200.8	IC50	=	200800	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Staphylococcus aureus

External ID: CHEMBL1764548

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL352
ChEMBL Target Name: Staphylococcus aureus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.78	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	25	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Bacillus subtilis

External ID: CHEMBL1764547

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL359
ChEMBL Target Name: Bacillus subtilis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.78	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	50	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	25	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	25	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Proteus vulgaris

External ID: CHEMBL1764550

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL614450
ChEMBL Target Name: Proteus vulgaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.78	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	50	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	12.5	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	12.5	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Micrococcus luteus

External ID: CHEMBL1764549

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL614421
ChEMBL Target Name: Micrococcus luteus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.78	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	50	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	25	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus fumigatus

External ID: CHEMBL1764552

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL363
ChEMBL Target Name: Aspergillus fumigatus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL1764551

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL998150

Protocol: N/A

Comment: Journal: J. Nat. Prod.
Year: 2005
Volume: 68
Issue: 5
First Page: 716
Last Page: 723
DOI: 10.1021/np058003i

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	87.4	%
Activity	=	90	%
Activity	=	90.5	%
Activity	=	89.6	%
Activity	=	87.3	%
Activity	=	88.2	%
Activity	=	90.4	%
Activity	=	87.8	%
Activity	=	90.4	%
Activity	=	89.1	%
Activity	=	89.2	%
Activity	=	90.1	%
Activity	=	88.7	%
Activity	=	88.7	%
Activity	=	88.8	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL1764554

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	3.12	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Salmonella enterica subsp. enterica serovar Typhimurium

External ID: CHEMBL1764553

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL351
ChEMBL Target Name: Salmonella typhimurium
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MIC	=	0.78	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	25	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	=	12.5	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1
MIC	>	100	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trichophyton mentagrophytes

External ID: CHEMBL1764556

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL613162
ChEMBL Target Name: Trichophyton mentagrophytes
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trichophyton rubrum

External ID: CHEMBL1764555

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2011
Volume: 21
Issue: 7
First Page: 1958
Last Page: 1961
DOI: 10.1016/j.bmcl.2011.02.035

Target ChEMBL ID: CHEMBL612649
ChEMBL Target Name: Trichophyton rubrum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

856414-51-2 靶点实验数据