HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dihydrofolate reductase

External ID: CHEMBL668117

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 2
First Page: 348
Last Page: 356
DOI: 10.1021/jm00385a017

Target ChEMBL ID: CHEMBL1809
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.44	IC50	=	440	nM
0.2	IC50	=	200	nM
0.15	IC50	=	150	nM
0.006	IC50	=	6	nM
0.066	IC50	=	66	nM
0.032	IC50	=	32	nM
0.003	IC50	=	3	nM
0.38	IC50	=	380	nM
0.01	IC50	=	10	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dihydrofolate reductase

External ID: CHEMBL667862

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 2
First Page: 348
Last Page: 356
DOI: 10.1021/jm00385a017

Target ChEMBL ID: CHEMBL2363
ChEMBL Target Name: Dihydrofolate reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
31	IC50	=	31000	nM
130	IC50	=	130000	nM	Outside typical range
250	IC50	=	250000	nM	Outside typical range
4.45	IC50	=	4450	nM
35	IC50	=	35000	nM
120	IC50	=	120000	nM	Outside typical range
30	IC50	=	30000	nM
0.11	IC50	=	110	nM
9.9	IC50	=	9900	nM

85544-45-2 靶点实验数据