HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mu-type opioid receptor

External ID: CHEMBL842482

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1993
Volume: 36
Issue: 6
First Page: 708
Last Page: 719
DOI: 10.1021/jm00058a007

Target ChEMBL ID: CHEMBL4354
ChEMBL Target Name: Mu opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0306	IC50	=	30.6	nM
2.66	IC50	=	2660	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Delta-type opioid receptor

External ID: CHEMBL754253

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1993
Volume: 36
Issue: 6
First Page: 708
Last Page: 719
DOI: 10.1021/jm00058a007

Target ChEMBL ID: CHEMBL3222
ChEMBL Target Name: Delta opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.202	IC50	=	202	nM
564.8	IC50	=	564800	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Delta-type opioid receptor

External ID: CHEMBL753240

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 6
First Page: 1400
Last Page: 1412
DOI: 10.1021/jm030311v

Target ChEMBL ID: CHEMBL3222
ChEMBL Target Name: Delta opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Ke	Agonist

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mu-type opioid receptor

External ID: CHEMBL758272

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 6
First Page: 1400
Last Page: 1412
DOI: 10.1021/jm030311v

Target ChEMBL ID: CHEMBL4354
ChEMBL Target Name: Mu opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.109	IC50	=	109	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL848172

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1993
Volume: 36
Issue: 6
First Page: 708
Last Page: 719
DOI: 10.1021/jm00058a007

Standard Type	Standard Relation	Standard Value
Ratio	=	60.4
Ratio	=	6.68
Ratio	=	10.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mu-type opioid receptor

External ID: CHEMBL755933

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 6
First Page: 1400
Last Page: 1412
DOI: 10.1021/jm030311v

Target ChEMBL ID: CHEMBL4354
ChEMBL Target Name: Mu opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	Ke				Agonist
	Ke				Agonist

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：IUPHAR-DB 靶标：mu receptor (Opioid receptors) [Homo sapiens]

External ID: 319_Human

Protocol: The International Union of Basic and Clinical Pharmacology/British Pharmacological Society (IUPHAR/BPS) Guide to PHARMACOLOGY Database (GtoPdb) uses expert subcommittees to collate peer-reviewed information from the published literature regarding individual protein targets, and describes the pharmacology, genetics, function and anatomy of each target. Its pages provide a richly curated overview of the pharmacology of receptors, ion channels, enzymes and other target types, which can be found by following the external link to the GtoPdb website.

Comment: The data collected focuses on ligands at human receptors. Data are provided at rat or mouse orthologues where there are significant species differences, or where data are not yet available at the human target.

Information on individual experimental protocols can be found in the primary references listed for each ligand.

Affinity data are expressed as pKi [-log(Ki)], pKd [-log(Kd)], pIC50 [-log(IC50)], pEC50 [-log(EC50)], pKB [-log(KB)], pA2 or as a micromolar concentration range. In most cases the original concentration can be found in the primary reference.

pKi_min	pKi_max	pIC50_min	pIC50_max	pKB_min	pKB_max	Type	Action	Reference (PubMed ID)
9.3	9.3					Antagonist	Antagonist	18313920
9.1	9.1					Agonist	Agonist	24713140
8.8	8.8					Agonist	Agonist	22695132
8.8	8.8					Agonist	Partial agonist	9686407
7.5	7.5					Agonist	Agonist	18788723
		8.4	8.4			Agonist	Agonist	11585443
5.8	5.8					Agonist	Agonist	19282177
7.9	7.9					Antagonist	Antagonist	9686407
10	10					Agonist	Partial agonist	9686407
		6.5	6.5			Agonist	Agonist	11585443
9.5	9.5					Agonist	Full agonist	9686407
8.7	8.7					Antagonist	Antagonist	19282177
8.7	8.7					Agonist	Partial agonist	21177476
9.9	9.9					Agonist	Partial agonist	18674902
				6	6	Allosteric modulator	Neutral	23754417
8.1	8.1					Agonist	Full agonist	9686407
10	10					Antagonist	Antagonist	9686407
7.7	7.7					Antagonist	Antagonist	9686407
6.6	6.6					Agonist	Agonist	18788723
9.1	9.7					Antagonist	Antagonist	9686407,24973897

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Delta-type opioid receptor

External ID: CHEMBL750386

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 6
First Page: 1400
Last Page: 1412
DOI: 10.1021/jm030311v

Target ChEMBL ID: CHEMBL3222
ChEMBL Target Name: Delta opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.213	IC50	=	213	nM

83397-56-2 靶点实验数据