HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4478411

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2016
Volume: 59
Issue: 13
First Page: 6265
Last Page: 6280
DOI: 10.1021/acs.jmedchem.6b00478

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	78	%
Activity	=	79	%
Activity	=	76	%
Activity	=	76	%
Activity	=	67	%
Activity	=	77	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cortical neurone

External ID: CHEMBL4478412

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2016
Volume: 59
Issue: 13
First Page: 6265
Last Page: 6280
DOI: 10.1021/acs.jmedchem.6b00478

Target ChEMBL ID: CHEMBL5314313
ChEMBL Target Name: Cortical neurone
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	18	%
Activity	=	0	%
Activity	=	77	%
Activity	=	11	%
Activity	=	19	%
Activity	=	30	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SH-SY5Y

External ID: CHEMBL4478413

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2016
Volume: 59
Issue: 13
First Page: 6265
Last Page: 6280
DOI: 10.1021/acs.jmedchem.6b00478

Target ChEMBL ID: CHEMBL614910
ChEMBL Target Name: SH-SY5Y
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	43	%
Activity	=	47	%
Activity	=	45	%
Activity	=	47	%
Activity	=	60	%
Activity	=	59	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1251387

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2010
Volume: 18
Issue: 19
First Page: 7078
Last Page: 7084
DOI: 10.1016/j.bmc.2010.08.003

Standard Type	Standard Relation	Standard Value	Standard Units
Solubility	=	19600	ug.mL-1
Solubility	=	57	ug.mL-1
Solubility	=	100	ug.mL-1
Solubility	=	84	ug.mL-1
Solubility	=	559	ug.mL-1
Solubility	=	80	ug.mL-1
Solubility	=	22	ug.mL-1
Solubility	=	580	ug.mL-1
Solubility	=	35	ug.mL-1
Solubility	=	816	ug.mL-1
Solubility	=	0.29	ug.mL-1
Solubility	=	1620	ug.mL-1
Solubility	=	19.6	ug.mL-1
Solubility	=	19.4	ug.mL-1
Solubility	=	200	ug.mL-1
Solubility	=	188.9	ug.mL-1
Solubility	=	25	ug.mL-1
Solubility	=	508	ug.mL-1
Solubility	=	6470	ug.mL-1
Solubility	=	2.7	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4478415

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2016
Volume: 59
Issue: 13
First Page: 6265
Last Page: 6280
DOI: 10.1021/acs.jmedchem.6b00478

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Activity	=	40	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：SH-SY5Y

External ID: CHEMBL4478416

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2016
Volume: 59
Issue: 13
First Page: 6265
Last Page: 6280
DOI: 10.1021/acs.jmedchem.6b00478

Target ChEMBL ID: CHEMBL614910
ChEMBL Target Name: SH-SY5Y
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic
Activity	Non-Toxic

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Voltage-dependent P/Q-type calcium channel subunit alpha-1A

External ID: CHEMBL4478408

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2016
Volume: 59
Issue: 13
First Page: 6265
Last Page: 6280
DOI: 10.1021/acs.jmedchem.6b00478

Target ChEMBL ID: CHEMBL2363032
ChEMBL Target Name: Voltage-gated calcium channel
ChEMBL Target Type: PROTEIN COMPLEX GROUP - Target is a poorly defined protein complex, where subunit composition is unclear (e.g., GABA-A receptor)
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	30	%
Inhibition	=	25	%
Inhibition	=	3	%
Inhibition	=	7	%
Inhibition	=	10	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL4478410

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2016
Volume: 59
Issue: 13
First Page: 6265
Last Page: 6280
DOI: 10.1021/acs.jmedchem.6b00478

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	77	%
Activity	=	76	%
Activity	=	80	%
Activity	=	80	%
Activity	=	74	%
Activity	=	79	%

830-93-3 靶点实验数据