HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sodium-dependent serotonin transporter

External ID: CHEMBL5136476

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med Chem Lett
Year: 2022
Volume: 13
Issue: 6.0
First Page: 888
Last Page: 890
DOI: 10.1021/acsmedchemlett.2c00214

Target ChEMBL ID: CHEMBL228
ChEMBL Target Name: Serotonin transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
1.9	IC50	=	1900	nM
0.026	IC50	=	26	nM
0.059	IC50	=	59	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Synaptic vesicular amine transporter

External ID: CHEMBL5136477

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: ACS Med Chem Lett
Year: 2022
Volume: 13
Issue: 6.0
First Page: 888
Last Page: 890
DOI: 10.1021/acsmedchemlett.2c00214

Target ChEMBL ID: CHEMBL4828
ChEMBL Target Name: Synaptic vesicular amine transporter
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.07	IC50	=	70	nM
3.3	IC50	=	3300	nM
0.17	IC50	=	170	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4395235

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2019
Volume: 174
First Page: 226
Last Page: 235
DOI: 10.1016/j.ejmech.2019.04.056

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MCF7

External ID: CHEMBL4395239

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2019
Volume: 174
First Page: 226
Last Page: 235
DOI: 10.1016/j.ejmech.2019.04.056

Target ChEMBL ID: CHEMBL387
ChEMBL Target Name: MCF7
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
20.53	IC50	=	20530	nM
44.75	IC50	=	44750	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sigma non-opioid intracellular receptor 1

External ID: CHEMBL4148655

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2018
Volume: 147
First Page: 227
Last Page: 237
DOI: 10.1016/j.ejmech.2017.11.016

Target ChEMBL ID: CHEMBL287
ChEMBL Target Name: Sigma opioid receptor
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.15	Ki	=	2150	nM
3.45	Ki	=	3450	nM
1.418	Ki	=	1418	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Sigma intracellular receptor 2

External ID: CHEMBL4148656

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2018
Volume: 147
First Page: 227
Last Page: 237
DOI: 10.1016/j.ejmech.2017.11.016

Target ChEMBL ID: CHEMBL4105907
ChEMBL Target Name: Sigma intracellular receptor 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
2.6E-4	Ki	=	0.26	nM
0.0126	Ki	=	12.6	nM
0.00519	Ki	=	5.19	nM

83-74-9 靶点实验数据