HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5256043

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2023
Volume: 83
First Page: 117255
Last Page: 117255
DOI: 10.1016/j.bmc.2023.117255

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	70.4	nmol/min/mg
Activity	=	142	nmol/min/mg
Activity	=	8.95	nmol/min/mg
Activity	=	19.1	nmol/min/mg
Activity	=	6.97	nmol/min/mg
Activity	=	12.8	nmol/min/mg
Activity	=	18.7	nmol/min/mg
Activity	=	39.5	nmol/min/mg
Activity	=	9.28	nmol/min/mg
Activity	=	82.4	nmol/min/mg
Activity	=	86.4	nmol/min/mg
Activity	=	56.1	nmol/min/mg
Activity	=	13	nmol/min/mg
Activity	=	70.1	nmol/min/mg
Activity	=	9	nmol/min/mg
Activity	=	23.1	nmol/min/mg
Activity	=	121	nmol/min/mg
Activity	=	21.3	nmol/min/mg
Activity	=	274	nmol/min/mg
Activity	=	29.6	nmol/min/mg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5256042

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2023
Volume: 83
First Page: 117255
Last Page: 117255
DOI: 10.1016/j.bmc.2023.117255

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	22.2	nmol/min/mg
Activity	=	43.1	nmol/min/mg
Activity	=	39.5	nmol/min/mg
Activity	=	9.22	nmol/min/mg
Activity	=	60.7	nmol/min/mg
Activity	=	35.7	nmol/min/mg
Activity	=	44.6	nmol/min/mg
Activity	=	99.9	nmol/min/mg
Activity	=	319	nmol/min/mg
Activity	=	4.76	nmol/min/mg
Activity	=	26.4	nmol/min/mg
Activity	=	38.1	nmol/min/mg
Activity	=	17.7	nmol/min/mg
Activity	=	109	nmol/min/mg
Activity	=	6.9	nmol/min/mg
Activity	=	7.68	nmol/min/mg
Activity	=	11.3	nmol/min/mg
Activity	=	9.45	nmol/min/mg
Activity	=	5.03	nmol/min/mg
Activity	=	5.98	nmol/min/mg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: MCF7_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, MCF7 is panel number 5, cell number 1. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	88.231	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	87.1119	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.4371	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.7113	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	97.2463	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	90.0129	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.7031	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	30.8539	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	14.2896	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.8526	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	83.1036	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	84.2194	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.3237	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	85.6034	1	1
2106OS49	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	89.6643	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	91.2503	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	94.8714	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	93.7372	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	112.6132	1	1
2106OS52	S	M	1.0E-5	5	1	Breast Cancer	MCF7	BRE	73.375	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：DTP/NCI 靶标：N/A

External ID: IGROV1_OneDose

Protocol: NCI-60 Human Tumor Cell Lines Screen was performed using the standard one-dose NCI protocol, which is described in more detail at https://dtp.cancer.gov/discovery_development/nci-60/default.htm.

Compounds with GIPRCNT values below 10 were considered active. Activity score was based on GIPRCNT using the following formula:
max(-GIPRCNT/2 + 50, 0)
Score is 0 for GIPRCNT values of 100 or above, 50 for GIPRCNT values of 0, and 100 for GIPRCNT values of -100.

Comment: These data are a subset of the data from the NCI human tumor cell line screen. Compounds are identified by the NCI National Service Center (NSC) number, which is contained in the
PUBCHEM_EXT_DATASOURCE_REGID field. In the NCI cell line identification system, IGROV1 is panel number 6, cell number 10. PANELCODE or PANELNAME identify the NCI-60 cell panel. PANELNBR does NOT identify the NCI-60 panel.

EXPID is the NCI internal tracking number for the experiment identifier, and PREFIX = 'S' for the NSCs submitted through the NCI Chemical Agents repository.

Substance concentration unit is indicated in the data table, using the following abbreviations: M = molar (M), u = micrograms/milliliter (microg/mL), V = volumetric fraction.

M_GIPRCNT represents the mean growth percent for that experiment, and N_GIPRCNT indicates the number of values for that NSC within an experiment, while STDEV_GIPRCNT is the standard deviation. Most NSCs are tested once per experiment, resulting in EXP_COUNT = 1.

EXPID	PREFIX	CONCENTRATION_UNIT	CONCENTRATION	PANELNBR	CELLNBR	PANELNAME	CELLNAME	PANELCODE	M_GIPRCNT	N_GIPRCNT	EXP_COUNT
0809OS51	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	89.6274	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	94.0185	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	77.1805	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	76.1686	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	82.5618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	88.7561	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	83.5845	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	92.7497	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	70.9555	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	58.7306	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.6041	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	90.3839	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	110.2345	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	97.6538	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	93.7697	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	56.4618	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	80.8893	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	79.078	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	-20.3008	1	1
0810OS71	S	M	1.0E-5	6	10	Ovarian Cancer	IGROV1	OVA	72.0949	1	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5256048

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2023
Volume: 83
First Page: 117255
Last Page: 117255
DOI: 10.1016/j.bmc.2023.117255

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	35.5	nmol/min/mg
Activity	=	54.1	nmol/min/mg
Activity	=	25.7	nmol/min/mg
Activity	=	46.2	nmol/min/mg
Activity	=	67.2	nmol/min/mg
Activity	=	73.9	nmol/min/mg
Activity	=	89.2	nmol/min/mg
Activity	=	130	nmol/min/mg
Activity	=	14.8	nmol/min/mg
Activity	=	22.9	nmol/min/mg
Activity	=	24.6	nmol/min/mg
Activity	=	73.1	nmol/min/mg
Activity	=	85.3	nmol/min/mg
Activity	=	10.2	nmol/min/mg
Activity	=	34.2	nmol/min/mg
Activity	=	95.7	nmol/min/mg
Activity	=	59.2	nmol/min/mg
Activity	=	37	nmol/min/mg
Activity	=	34	nmol/min/mg
Activity	=	53.2	nmol/min/mg

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL5256049

Protocol: N/A

Comment: Journal: Bioorg Med Chem
Year: 2023
Volume: 83
First Page: 117255
Last Page: 117255
DOI: 10.1016/j.bmc.2023.117255

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	21.7	nmol/min/mg
Activity	=	60.3	nmol/min/mg
Activity	=	99.1	nmol/min/mg
Activity	=	37.1	nmol/min/mg
Activity	=	29.4	nmol/min/mg
Activity	=	62.1	nmol/min/mg
Activity	=	14.3	nmol/min/mg
Activity	=	337	nmol/min/mg
Activity	=	593	nmol/min/mg
Activity	=	31.5	nmol/min/mg
Activity	=	15.9	nmol/min/mg
Activity	=	157	nmol/min/mg
Activity	=	122.1	nmol/min/mg
Activity	=	221	nmol/min/mg
Activity	=	158	nmol/min/mg
Activity	=	23.4	nmol/min/mg
Activity	=	62.2	nmol/min/mg
Activity	=	189	nmol/min/mg
Activity	=	364	nmol/min/mg
Activity	=	363	nmol/min/mg

823-76-7 靶点实验数据