HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide sythases; iNOS & nNOS

External ID: CHEMBL848735

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 17
First Page: 1975
Last Page: 1978
DOI: 10.1016/s0960-894x(00)00389-9

Target ChEMBL ID: CHEMBL2096621
ChEMBL Target Name: Nitric oxide sythases; iNOS & nNOS
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Selectivity	=	5.6
Selectivity	=	1.5
Selectivity	=	0.4
Selectivity	=	0.8
Selectivity	=	0.4
Selectivity	=	1
Selectivity	=	2.7
Selectivity	=	0.4
Selectivity	=	0.2
Selectivity	=	2.6
Selectivity	=	1.4
Selectivity	=	1.4
Selectivity	=	9.1
Selectivity	=	0.3
Selectivity	=	1.8
Selectivity	=	0.15
Selectivity	=	25
Selectivity	=	5.4
Selectivity	=	1.2
Selectivity	=	5.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase, inducible

External ID: CHEMBL700509

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 17
First Page: 1975
Last Page: 1978
DOI: 10.1016/s0960-894x(00)00389-9

Target ChEMBL ID: CHEMBL4481
ChEMBL Target Name: Nitric oxide synthase, inducible
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.17	IC50	=	170	nM
1.7	IC50	=	1700	nM
29	IC50	=	29000	nM
50	IC50	>	50000	nM
50	IC50	>	50000	nM
7.2	IC50	=	7200	nM
0.23	IC50	=	230	nM
0.046	IC50	=	46	nM
2	IC50	=	2000	nM
14.6	IC50	=	14600	nM
1.3	IC50	=	1300	nM
0.059	IC50	=	59	nM
34.5	IC50	=	34500	nM
12.7	IC50	=	12700	nM
0.11	IC50	=	110	nM
50	IC50	>	50000	nM
4.6	IC50	=	4600	nM
0.11	IC50	=	110	nM
0.33	IC50	=	330	nM
0.076	IC50	=	76	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase, endothelial

External ID: CHEMBL676782

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 17
First Page: 1975
Last Page: 1978
DOI: 10.1016/s0960-894x(00)00389-9

Target ChEMBL ID: CHEMBL4803
ChEMBL Target Name: Nitric-oxide synthase, endothelial
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
0.072	IC50	=	72	nM
	IC50			nM	Not Determined
24	IC50	=	24000	nM
	IC50			nM	Not Determined
	IC50			nM	Not Determined
2.8	IC50	=	2800	nM
0.23	IC50	=	230	nM
0.82	IC50	=	820	nM
3.6	IC50	=	3600	nM
3.4	IC50	=	3400	nM
0.081	IC50	=	81	nM
	IC50			nM	Not Determined
17.2	IC50	=	17200	nM
1	IC50	=	1000	nM
	IC50			nM	Not Determined
1.4	IC50	=	1400	nM
0.2	IC50	=	200	nM
0.049	IC50	=	49	nM
1.9	IC50	=	1900	nM
0.15	IC50	=	150	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide sythases; iNOS & nNOS

External ID: CHEMBL840530

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 17
First Page: 1975
Last Page: 1978
DOI: 10.1016/s0960-894x(00)00389-9

Target ChEMBL ID: CHEMBL2096621
ChEMBL Target Name: Nitric oxide sythases; iNOS & nNOS
ChEMBL Target Type: SELECTIVITY GROUP - Target is a pair of proteins for which the selectivity has been assessed
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Activity Comment
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined
Selectivity	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nitric oxide synthase, brain

External ID: CHEMBL750654

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2000
Volume: 10
Issue: 17
First Page: 1975
Last Page: 1978
DOI: 10.1016/s0960-894x(00)00389-9

Target ChEMBL ID: CHEMBL3568
ChEMBL Target Name: Nitric-oxide synthase, brain
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50			nM	Not Determined
11	IC50	=	11000	nM
	IC50			nM	Not Determined
	IC50			nM	Not Determined
2.2	IC50	=	2200	nM
	IC50			nM	Not Determined
	IC50			nM	Not Determined
2	IC50	=	2000	nM
0.61	IC50	=	610	nM
	IC50			nM	Not Determined
	IC50			nM	Not Determined
3.3	IC50	=	3300	nM
0.09	IC50	=	90	nM
	IC50			nM	Not Determined
6.6	IC50	=	6600	nM
1.2	IC50	=	1200	nM
0.51	IC50	=	510	nM
0.1	IC50	=	100	nM
	IC50			nM	Not Determined
	IC50			nM	Not Determined

823-39-2 靶点实验数据