HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL672828

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 7
First Page: 1195
Last Page: 1201
DOI: 10.1021/jm00157a013

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
ED50	=	0.001	mg.kg-1
ED50	=	8.0E-5	mg.kg-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL851310

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 7
First Page: 1195
Last Page: 1201
DOI: 10.1021/jm00157a013

Standard Type	Standard Relation	Standard Value
Ratio	=	1240
Ratio	=	1307

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL851137

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 6
First Page: 786
Last Page: 790
DOI: 10.1021/jm00360a002

Standard Type	Standard Relation	Standard Value
Therapeutic index	=	208
Therapeutic index	=	66.5

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL884427

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 6
First Page: 786
Last Page: 790
DOI: 10.1021/jm00360a002

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
ED50	=	1.0E-4	mg.kg-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL779796

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 5
First Page: 1001
Last Page: 1006
DOI: 10.1021/jm00125a013

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.049	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL780962

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 6
First Page: 786
Last Page: 790
DOI: 10.1021/jm00360a002

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.062	mg.kg-1
ED50	=	0.366	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL783762

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1992
Volume: 35
Issue: 4
First Page: 694
Last Page: 704
DOI: 10.1021/jm00082a010

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.049	mg.kg-1
ED50	>	3.16	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL669710

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1989
Volume: 32
Issue: 5
First Page: 1001
Last Page: 1006
DOI: 10.1021/jm00125a013

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
ED50	=	2.3E-5	mg.kg-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL671105

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 7
First Page: 1195
Last Page: 1201
DOI: 10.1021/jm00157a013

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
ED50	=	5.0E-5	mg.kg-1	Outside typical range
ED50	=	2.8E-4	mg.kg-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL847410

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1992
Volume: 35
Issue: 4
First Page: 694
Last Page: 704
DOI: 10.1021/jm00082a010

Standard Type	Standard Relation	Standard Value
Ratio	=	2
Ratio	>	158

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL667793

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 7
First Page: 1195
Last Page: 1201
DOI: 10.1021/jm00157a013

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	92	%
Inhibition	=	79	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL883147

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 10
First Page: 2784
Last Page: 2793
DOI: 10.1021/jm00172a017

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
ED50	=	2.3E-5	mg.kg-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL671166

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1992
Volume: 35
Issue: 4
First Page: 694
Last Page: 704
DOI: 10.1021/jm00082a010

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
ED50	=	2.3E-5	mg.kg-1	Outside typical range
ED50	=	2.0E-5	mg.kg-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL781938

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1986
Volume: 29
Issue: 7
First Page: 1195
Last Page: 1201
DOI: 10.1021/jm00157a013

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.062	mg.kg-1
ED50	=	0.366	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL781332

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 10
First Page: 2784
Last Page: 2793
DOI: 10.1021/jm00172a017

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.049	mg.kg-1
ED50	>	3.16	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL669602

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1983
Volume: 26
Issue: 6
First Page: 786
Last Page: 790
DOI: 10.1021/jm00360a002

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
ED50	=	3.0E-4	mg.kg-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Canis lupus familiaris

External ID: CHEMBL671168

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 11
First Page: 1952
Last Page: 1955
DOI: 10.1021/jm00394a004

Target ChEMBL ID: CHEMBL373
ChEMBL Target Name: Canis familiaris
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
ED50	=	2.3E-5	mg.kg-1	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL789318

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1987
Volume: 30
Issue: 11
First Page: 1952
Last Page: 1955
DOI: 10.1021/jm00394a004

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
MED	=	1	ug kg-1

81026-63-3 靶点实验数据