HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saimiri sciureus

External ID: CHEMBL936473

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL613821
ChEMBL Target Name: Squirrel monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1

External ID: CHEMBL5616320

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2024
Volume: 277
First Page: 116774
Last Page: 116774
DOI: 10.1016/j.ejmech.2024.116774

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Tyrosine-protein phosphatase non-receptor type 1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.12	IC50	=	120	nM
0.01	IC50	<	10	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saimiri sciureus

External ID: CHEMBL936474

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL613821
ChEMBL Target Name: Squirrel monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	>	30	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 2

External ID: CHEMBL5616321

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2024
Volume: 277
First Page: 116774
Last Page: 116774
DOI: 10.1016/j.ejmech.2024.116774

Target ChEMBL ID: CHEMBL3807
ChEMBL Target Name: Tyrosine-protein phosphatase non-receptor type 2
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.01	IC50	=	10	nM
0.013	IC50	=	13	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Saimiri sciureus

External ID: CHEMBL936475

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL613821
ChEMBL Target Name: Squirrel monkey
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	0.02	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1

External ID: CHEMBL1767946

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 7
First Page: 2145
Last Page: 2155
DOI: 10.1016/j.bmc.2011.02.047

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
40	IC50	=	40000	nM
0.12	IC50	=	120	nM
1.3	IC50	=	1300	nM
0.14	IC50	=	140	nM
0.08	IC50	=	80	nM
0.13	IC50	=	130	nM
3.3	IC50	=	3300	nM
0.026	Ki	=	26	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL936468

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	4	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL936469

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	>	17	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL936470

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	0.03	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL936480

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	100	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL936481

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
ED50	=	0.8	mg.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1071699

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 6
First Page: 2333
Last Page: 2344
DOI: 10.1021/jm901090b

Standard Type	Standard Relation	Standard Value
Ratio IC50	=	1
Ratio IC50	=	1.9
Ratio IC50	=	0.8
Ratio IC50	=	1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1

External ID: CHEMBL1071696

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 6
First Page: 2333
Last Page: 2344
DOI: 10.1021/jm901090b

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
2.1	Ki	=	2100	nM
1600	IC50	=	1600000	nM	Outside typical range
2.5	IC50	=	2500	nM
0.028	IC50	=	28	nM
4.8	IC50	=	4800	nM
0.004	Ki	=	4	nM
0.12	IC50	=	120	nM
20	IC50	>	20000	nM
0.005	IC50	=	5	nM
0.6	IC50	=	600	nM
0.016	IC50	=	16	nM
8	IC50	=	8000	nM
4.1	IC50	=	4100	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 2

External ID: CHEMBL1071697

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2010
Volume: 53
Issue: 6
First Page: 2333
Last Page: 2344
DOI: 10.1021/jm901090b

Target ChEMBL ID: CHEMBL3807
ChEMBL Target Name: T-cell protein-tyrosine phosphatase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
30	IC50	>	30000	nM
9.4	IC50	=	9400	nM
0.005	Ki	=	5	nM
0.12	IC50	=	120	nM
0.036	IC50	=	36	nM
0.065	Ki	=	65	nM
200	Ki	>	200000	nM	Outside typical range
0.025	IC50	=	25	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL936478

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	60	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL936479

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	80	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1

External ID: CHEMBL936456

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL335
ChEMBL Target Name: Protein-tyrosine phosphatase 1B
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.12	IC50	=	120	nM
0.09	IC50	=	90	nM
0.33	IC50	=	330	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_1136_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.26	260	P17706	BDBM310919	Tyrosine-protein phosphatase non-receptor type 2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Receptor-type tyrosine-protein phosphatase C

External ID: CHEMBL936457

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL3243
ChEMBL Target Name: Leukocyte common antigen
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
50	IC50	>	50000	nM
26.8	IC50	=	26800	nM
50	IC50	>	50000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL936464

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
T1/2	=	6	hr

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_11172_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	IC50	Target Accession(s)	Ligand	Target
IC50	0.26	260	P17706	BDBM310919	Tyrosine-protein phosphatase non-receptor type 2

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL936465

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
CL	=	0.71	mL.min-1.kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Mus musculus

External ID: CHEMBL936463

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2008
Volume: 18
Issue: 11
First Page: 3200
Last Page: 3205
DOI: 10.1016/j.bmcl.2008.04.064

Target ChEMBL ID: CHEMBL375
ChEMBL Target Name: Mus musculus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
F	=	24	%

809272-64-8 靶点实验数据