HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL699877

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2002
Volume: 45
Issue: 14
First Page: 2904
Last Page: 2914
DOI: 10.1021/jm0102809

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
218	LD50	=	218	uM
806	LD50	>	806	uM
775	LD50	>	775	uM
746	LD50	>	746	uM
249	LD50	=	249	uM
13.9	LD50	=	13.9	uM
931	LD50	>	931	uM
680	LD50	=	680	uM
1052	LD50	>	1052	uM
1149	LD50	>	1149	uM
804	LD50	>	804	uM
1149	LD50	>	1149	uM
809	LD50	=	809	uM
41	LD50	=	41	uM
1041	LD50	>	1041	uM
967	LD50	>	967	uM
10.1	LD50	=	10.1	uM
87	LD50	=	87	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Farnesyl pyrophosphate synthase

External ID: CHEMBL924793

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2008
Volume: 51
Issue: 7
First Page: 2187
Last Page: 2195
DOI: 10.1021/jm7015733

Target ChEMBL ID: CHEMBL1782
ChEMBL Target Name: Farnesyl diphosphate synthase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.3931	Ki	=	393.1	nM
0.0752	IC50	=	75.2	nM
0.0121	Ki	=	12.1	nM
0.4529	IC50	=	452.9	nM
0.0822	Ki	=	82.2	nM
0.166	IC50	=	166	nM
0.0291	Ki	=	29.1	nM
0.3491	IC50	=	349.1	nM
0.3679	Ki	=	367.9	nM
2.427	IC50	=	2427	nM
0.1941	Ki	=	194.1	nM
0.3656	IC50	=	365.6	nM
0.3626	Ki	=	362.6	nM
0.1901	IC50	=	190.1	nM
0.0369	Ki	=	36.9	nM
1.052	IC50	=	1052	nM
0.195	Ki	=	195	nM
1.892	IC50	=	1892	nM
0.3197	Ki	=	319.7	nM
0.2588	IC50	=	258.8	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Farnesyl pyrophosphate synthase

External ID: CHEMBL924794

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2008
Volume: 51
Issue: 7
First Page: 2187
Last Page: 2195
DOI: 10.1021/jm7015733

Target ChEMBL ID: CHEMBL1782
ChEMBL Target Name: Farnesyl diphosphate synthase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.0442	Ki	=	44.2	nM
0.0062	IC50	=	6.2	nM
0.00109	Ki	=	1.09	nM
0.0057	IC50	=	5.7	nM
3.6E-4	Ki	=	0.36	nM
0.0117	IC50	=	11.7	nM
0.0023	Ki	=	2.3	nM
0.0092	IC50	=	9.2	nM
0.3026	Ki	=	302.6	nM
0.3882	IC50	=	388.2	nM
0.0482	Ki	=	48.2	nM
0.0611	IC50	=	61.1	nM
0.078	Ki	=	78	nM
0.015	IC50	=	15	nM
0.0023	Ki	=	2.3	nM
0.0254	IC50	=	25.4	nM
0.0036	Ki	=	3.6	nM
0.0614	IC50	=	61.4	nM
0.0116	Ki	=	11.6	nM
0.0304	IC50	=	30.4	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL924795

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2008
Volume: 51
Issue: 7
First Page: 2187
Last Page: 2195
DOI: 10.1021/jm7015733

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
LED	=	0.03	mg kg-1
LED	=	0.001	mg kg-1
LED	=	0.001	mg kg-1
LED	=	3.0E-4	mg kg-1
LED	=	0.001	mg kg-1
LED	=	0.01	mg kg-1
LED	=	0.001	mg kg-1
LED	=	1	mg kg-1
LED	=	0.01	mg kg-1
LED	=	1.0E-4	mg kg-1
LED	=	0.01	mg kg-1
LED	=	0.01	mg kg-1
LED	=	1.0E-4	mg kg-1
LED	=	0.001	mg kg-1
LED	=	0.3	mg kg-1
LED	=	3.0E-4	mg kg-1
LED	=	0.001	mg kg-1
LED	=	1.0E-4	mg kg-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Geranylgeranyl pyrophosphate synthase

External ID: CHEMBL681671

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 11
First Page: 2185
Last Page: 2196
DOI: 10.1021/jm010412y

Target ChEMBL ID: CHEMBL4769
ChEMBL Target Name: Geranylgeranyl pyrophosphate synthetase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
260	IC50	=	260000	nM	Outside typical range
180	IC50	=	180000	nM	Outside typical range
1.4	IC50	=	1400	nM
330	IC50	=	330000	nM	Outside typical range
350	IC50	=	350000	nM	Outside typical range
53	IC50	=	53000	nM
11	IC50	=	11000	nM
220	IC50	=	220000	nM	Outside typical range
690	IC50	=	690000	nM	Outside typical range
19	IC50	=	19000	nM
220	IC50	=	220000	nM	Outside typical range
620	IC50	=	620000	nM	Outside typical range
0.37	IC50	=	370	nM
0.31	IC50	=	310	nM
240	IC50	=	240000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL998577

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2008
Volume: 16
Issue: 19
First Page: 8959
Last Page: 8967
DOI: 10.1016/j.bmc.2008.08.047

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
316.228	IC50	=	316227.77	nM	Outside typical range
302	IC50	=	302000	nM	Outside typical range
316.228	IC50	=	316227.77	nM	Outside typical range
302	IC50	=	302000	nM	Outside typical range
316.228	IC50	=	316227.77	nM	Outside typical range
302	IC50	=	302000	nM	Outside typical range
1.25893	IC50	=	1258.93	nM
7.9	IC50	=	7900	nM
1	IC50	=	1000	nM
10	IC50	=	10000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania donovani

External ID: CHEMBL706169

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2001
Volume: 44
Issue: 6
First Page: 909
Last Page: 916
DOI: 10.1021/jm0002578

Target ChEMBL ID: CHEMBL367
ChEMBL Target Name: Leishmania donovani
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
2.3	IC50	=	2300	nM
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
82.1	IC50	=	82100	nM
200	IC50	>	200000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL681825

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 2
First Page: 375
Last Page: 384
DOI: 10.1021/jm0303709

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
13	IC50	=	13000	nM
251	IC50	=	251000	nM	Outside typical range
11	IC50	=	11000	nM
22	IC50	=	22000	nM
6.9	IC50	=	6900	nM
213	IC50	=	213000	nM	Outside typical range
12	IC50	=	12000	nM
14	IC50	=	14000	nM
190	IC50	=	190000	nM	Outside typical range
66	IC50	=	66000	nM
41	IC50	=	41000	nM
7.4	IC50	=	7400	nM
63	IC50	=	63000	nM
1.96	IC50	=	1960	nM
11	IC50	=	11000	nM
40	IC50	=	40000	nM
25	IC50	=	25000	nM
44	IC50	=	44000	nM
56	IC50	=	56000	nM
18	IC50	=	18000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL681824

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 2
First Page: 375
Last Page: 384
DOI: 10.1021/jm0303709

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
14	IC50	=	14000	nM
19939	IC50	=	19939000	nM	Outside typical range
13	IC50	=	13000	nM
21	IC50	=	21000	nM
6.2	IC50	=	6200	nM
2111	IC50	=	2111000	nM	Outside typical range
28	IC50	=	28000	nM
24	IC50	=	24000	nM
597	IC50	=	597000	nM	Outside typical range
122	IC50	=	122000	nM	Outside typical range
83	IC50	=	83000	nM
16	IC50	=	16000	nM
121	IC50	=	121000	nM	Outside typical range
503	IC50	=	503000	nM	Outside typical range
15	IC50	=	15000	nM
47	IC50	=	47000	nM
55	IC50	=	55000	nM
110	IC50	=	110000	nM	Outside typical range
127	IC50	=	127000	nM	Outside typical range
35	IC50	=	35000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL681827

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 2
First Page: 375
Last Page: 384
DOI: 10.1021/jm0303709

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
12.5892	IC50	=	12589.25	nM
251.189	IC50	=	251188.64	nM	Outside typical range
11.2202	IC50	=	11220.18	nM
21.3796	IC50	=	21379.62	nM
6.91831	IC50	=	6918.31	nM
213.796	IC50	=	213796.21	nM	Outside typical range
12.0226	IC50	=	12022.64	nM
14.4544	IC50	=	14454.4	nM
190.546	IC50	=	190546.07	nM	Outside typical range
66.0693	IC50	=	66069.34	nM
40.738	IC50	=	40738.03	nM
7.4131	IC50	=	7413.1	nM
63.0957	IC50	=	63095.73	nM
194.984	IC50	=	194984.46	nM	Outside typical range
11.4815	IC50	=	11481.54	nM
39.8107	IC50	=	39810.72	nM
25.1189	IC50	=	25118.86	nM
43.6516	IC50	=	43651.58	nM
56.2341	IC50	=	56234.13	nM
18.197	IC50	=	18197.01	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL681826

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2004
Volume: 47
Issue: 2
First Page: 375
Last Page: 384
DOI: 10.1021/jm0303709

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
14.4544	IC50	=	14454.4	nM
19952.6	IC50	=	1.995262315E7	nM	Outside typical range
12.8825	IC50	=	12882.5	nM
20.893	IC50	=	20892.96	nM
6.16595	IC50	=	6165.95	nM
2089.3	IC50	=	2089296.13	nM	Outside typical range
28.1838	IC50	=	28183.83	nM
23.9883	IC50	=	23988.33	nM
602.56	IC50	=	602559.59	nM	Outside typical range
120.226	IC50	=	120226.44	nM	Outside typical range
83.1764	IC50	=	83176.38	nM
15.4882	IC50	=	15488.17	nM
120.226	IC50	=	120226.44	nM	Outside typical range
501.187	IC50	=	501187.23	nM	Outside typical range
14.7911	IC50	=	14791.08	nM
46.7735	IC50	=	46773.51	nM
54.9541	IC50	=	54954.09	nM
109.648	IC50	=	109647.82	nM	Outside typical range
125.893	IC50	=	125892.54	nM	Outside typical range
34.6737	IC50	=	34673.69	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL700364

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 1
First Page: 175
Last Page: 187
DOI: 10.1021/jm030084x

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
187	LD50	=	187	uM
127	LD50	=	127	uM
218	LD50	=	218	uM
1098	LD50	>	1098	uM
729	LD50	>	729	uM
36.8	LD50	=	36.8	uM
1009	LD50	>	1009	uM
963	LD50	>	963	uM
775	LD50	>	775	uM
746	LD50	>	746	uM
922	LD50	>	922	uM
257	LD50	=	257	uM
466	LD50	=	466	uM
492	LD50	=	492	uM
18.6	LD50	=	18.6	uM
782	LD50	=	782	uM
727	LD50	>	727	uM
1119	LD50	>	1119	uM
1090	LD50	>	1090	uM
322	LD50	=	322	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hydroxyapatite

External ID: CHEMBL2026311

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Target ChEMBL ID: CHEMBL2363055
ChEMBL Target Name: Hydroxyapatite
ChEMBL Target Type: MACROMOLECULE - Target is a biological macromolecule (e.g., glycoproteins, hemozoin, hydroxyapatite)
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	100	%
Activity	=	98	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2

External ID: CHEMBL4513082

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	0.24	%
Inhibition	=	4.58	%
Inhibition	=	-0.3	%
Inhibition	=	-0.3	%
Inhibition	=	-0.04	%
Inhibition	=	-0.04	%
Inhibition	=	-0.08	%
Inhibition	=	-0.08	%
Inhibition	=	-0.08	%
Inhibition	=	-0.08	%
Inhibition	=	0.03	%
Inhibition	=	0	%
Inhibition	=	0.03	%
Inhibition	=	0	%
Inhibition	=	-0.27	%
Inhibition	=	-0.27	%
Inhibition	=	-0.08	%
Inhibition	=	-0.08	%
Inhibition	=	14.41	%
Inhibition	=	0.39	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2

External ID: CHEMBL4303805

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4303835
ChEMBL Target Name: SARS-CoV-2
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Inhibition	=	-11.52	%	Outside typical range
Inhibition	=	5.09	%
Inhibition	=	-1.71	%
Inhibition	=	3.69	%
Inhibition	=	22.47	%
Inhibition	=	8.51	%
Inhibition	=	-6.86	%
Inhibition	=	-6.18	%
Inhibition	=	-2.07	%
Inhibition	=	3.91	%
Inhibition	=	-5.9	%
Inhibition	=	-2.45	%
Inhibition	=	-5.55	%
Inhibition	=	6.31	%
Inhibition	=	-1.08	%
Inhibition	=	12.7	%
Inhibition	=	0.37	%
Inhibition	=	8.88	%
Inhibition	=	11.63	%
Inhibition	=	-1.96	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2026322

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Standard Type	Standard Relation	Standard Value
LogD	=	-1.32
LogD	=	-8.01

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2026321

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Standard Type	Standard Relation	Standard Value
LogD	=	-5.04
LogD	=	-8.02

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL1217000

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2010
Volume: 18
Issue: 6
First Page: 2225
Last Page: 2231
DOI: 10.1016/j.bmc.2010.01.068

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50	=	0	nM		Outside typical range
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
6	IC50	=	6000	nM
	IC50				Not Determined
	IC50	=	0	nM		Outside typical range
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
100	IC50	=	100000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：PBMC

External ID: CHEMBL2026326

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Target ChEMBL ID: CHEMBL613107
ChEMBL Target Name: PBMC
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Units	Activity Comment
Inhibition	%	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：L929

External ID: CHEMBL2026324

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Target ChEMBL ID: CHEMBL612267
ChEMBL Target Name: L929
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Dose-dependent effect

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hydroxyapatite

External ID: CHEMBL2026315

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Target ChEMBL ID: CHEMBL2363055
ChEMBL Target Name: Hydroxyapatite
ChEMBL Target Type: MACROMOLECULE - Target is a biological macromolecule (e.g., glycoproteins, hemozoin, hydroxyapatite)
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	100	%
Activity	=	85	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL753354

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2001
Volume: 44
Issue: 6
First Page: 909
Last Page: 916
DOI: 10.1021/jm0002578

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
158	IC50	=	158000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
7.7	IC50	=	7700	nM
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
56.7	IC50	=	56700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hydroxyapatite

External ID: CHEMBL2026313

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Target ChEMBL ID: CHEMBL2363055
ChEMBL Target Name: Hydroxyapatite
ChEMBL Target Type: MACROMOLECULE - Target is a biological macromolecule (e.g., glycoproteins, hemozoin, hydroxyapatite)
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	100	%
Activity	=	96	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Entamoeba histolytica

External ID: CHEMBL1217007

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2010
Volume: 18
Issue: 6
First Page: 2225
Last Page: 2231
DOI: 10.1016/j.bmc.2010.01.068

Target ChEMBL ID: CHEMBL612853
ChEMBL Target Name: Entamoeba histolytica
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined
	IC50				Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hydroxyapatite

External ID: CHEMBL2026319

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Target ChEMBL ID: CHEMBL2363055
ChEMBL Target Name: Hydroxyapatite
ChEMBL Target Type: MACROMOLECULE - Target is a biological macromolecule (e.g., glycoproteins, hemozoin, hydroxyapatite)
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	93	%
Activity	=	67	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Hydroxyapatite

External ID: CHEMBL2026317

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Target ChEMBL ID: CHEMBL2363055
ChEMBL Target Name: Hydroxyapatite
ChEMBL Target Type: MACROMOLECULE - Target is a biological macromolecule (e.g., glycoproteins, hemozoin, hydroxyapatite)
Relationship Type: M - Molecular target other than protein assigned
Confidence: Target assigned is molecular non-protein target

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	96	%
Activity	=	82	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL835402

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2005
Volume: 48
Issue: 9
First Page: 3130
Last Page: 3140
DOI: 10.1021/jm040132t

Standard Type	Standard Relation	Standard Value
TI	=	4.11
TI	=	1.33
TI	=	4.02
TI	=	2.71
TI	>	12.24
TI	>	1621.82
TI	=	48.86
TI	=	106.25
TI	=	21.88
TI	=	4.23
TI	=	18.64
TI	>	6.73
TI	>	21.85
TI	>	7.99
TI	=	1.71
TI	=	11.39
TI	=	4.19
TI	>	20.07
TI	=	9.19
TI	=	8.19

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Entamoeba histolytica

External ID: CHEMBL676676

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 1
First Page: 175
Last Page: 187
DOI: 10.1021/jm030084x

Target ChEMBL ID: CHEMBL612853
ChEMBL Target Name: Entamoeba histolytica
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
44	IC50	=	44000	nM
74	IC50	=	74000	nM
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
13.3	IC50	=	13300	nM
200	IC50	>	200000	nM	Outside typical range
71	IC50	=	71000	nM
96.1	IC50	=	96100	nM
39.5	IC50	=	39500	nM
63.7	IC50	=	63700	nM
64	IC50	=	64000	nM
60	IC50	=	60000	nM
20.5	IC50	=	20500	nM
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma cruzi

External ID: CHEMBL813357

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2001
Volume: 44
Issue: 6
First Page: 909
Last Page: 916
DOI: 10.1021/jm0002578

Target ChEMBL ID: CHEMBL368
ChEMBL Target Name: Trypanosoma cruzi
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
123	IC50	=	123000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：HFF

External ID: CHEMBL874944

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2005
Volume: 48
Issue: 9
First Page: 3130
Last Page: 3140
DOI: 10.1021/jm040132t

Target ChEMBL ID: CHEMBL614071
ChEMBL Target Name: HFF
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
59.04	IC50	=	59040	nM
80.34	IC50	=	80340	nM
89.77	IC50	=	89770	nM
0.55	IC50	=	550	nM
72.52	IC50	=	72520	nM
2.4	IC50	=	2400	nM
25.31	IC50	=	25310	nM
41.95	IC50	=	41950	nM
160.8	IC50	=	160800	nM	Outside typical range
51.22	IC50	=	51220	nM
132	IC50	=	132000	nM	Outside typical range
44.63	IC50	=	44630	nM
8.11	IC50	=	8110	nM
90.23	IC50	=	90230	nM
126.4	IC50	=	126400	nM	Outside typical range
30.92	IC50	=	30920	nM
68.43	IC50	=	68430	nM
43.22	IC50	=	43220	nM
120.9	IC50	=	120900	nM	Outside typical range
69.25	IC50	=	69250	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：NIAID 靶标：N/A

External ID: HIV Enzyme Data

Protocol: N/A

Comment: N/A

Species	Strain	IsPseudotypeVirus	AssayMeth	Target	IC50Mod	IC50	IC50Unit	Ki	KiUnit	Reference	Citation
			3' PROCESSING	Integrase	>	100	uM			18662877	EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4.
			3' PROCESSING	Integrase	>	100	uM			18662877	EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4.
			3' PROCESSING	Integrase	>	100	uM			18662877	EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4.
			STRAND TRANSFER	Integrase	>	100	uM			18662877	EFFICIENT SYNTHESIS AND UTILIZATION OF PHENYL-SUBSTITUTED HETEROAROMATIC CARBOXYLIC ACIDS AS ARYL DIKETO ACID ISOSTERES IN THE DESIGN OF NOVEL HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2008, 18(16), 4521-4.
	HIV-1		dTTP incorporation assay by liquid scintillation	Reverse transcriptase				6.2	uM	19442130	CHARACTERIZATION OF HIV-1 ENZYME REVERSE TRANSCRIPTASE INHIBITION BY THE COMPOUND 6-CHLORO-1,4-DIHYDRO-4-OXO-1-(BETA-D-RIBOFURANOSYL) QUINOLINE-3-CARBOXYLIC ACID THROUGH KINETIC AND IN SILICO STUDIES. Current HIV Research 2009, 7(3), 327-335.
	HIV-1		dTTP incorporation assay by liquid scintillation	Reverse transcriptase				5.3	uM	19442130	CHARACTERIZATION OF HIV-1 ENZYME REVERSE TRANSCRIPTASE INHIBITION BY THE COMPOUND 6-CHLORO-1,4-DIHYDRO-4-OXO-1-(BETA-D-RIBOFURANOSYL) QUINOLINE-3-CARBOXYLIC ACID THROUGH KINETIC AND IN SILICO STUDIES. Current HIV Research 2009, 7(3), 327-335.
	HIV-1		dTTP incorporation assay by liquid scintillation	Reverse transcriptase				5	uM	19442130	CHARACTERIZATION OF HIV-1 ENZYME REVERSE TRANSCRIPTASE INHIBITION BY THE COMPOUND 6-CHLORO-1,4-DIHYDRO-4-OXO-1-(BETA-D-RIBOFURANOSYL) QUINOLINE-3-CARBOXYLIC ACID THROUGH KINETIC AND IN SILICO STUDIES. Current HIV Research 2009, 7(3), 327-335.
HIV-1		N	standard reverse transcriptase assay	Reverse transcriptase		50	ug/mL				SYNTHESIS AND HIV-1 REVERSE TRANSCRIPTASE INHIBITION ACTIVITY OF 1,4-NAPHTHOQUINONE DERIVATIVES. Chemistry of Natural Compounds 2012, 47(6), 883-887.
			STRAND TRANSFER	Integrase	>	100	uM			18805696	DISCOVERY OF 3-ACETYL-4-HYDROXY-2-PYRANONE DERIVATIVES AND THEIR DIFLUORIDOBORATE COMPLEXES AS A NOVEL CLASS OF HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry 2008, 16(19), 8988-98.
			STRAND TRANSFER	Integrase	>	100	uM			18805696	DISCOVERY OF 3-ACETYL-4-HYDROXY-2-PYRANONE DERIVATIVES AND THEIR DIFLUORIDOBORATE COMPLEXES AS A NOVEL CLASS OF HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry 2008, 16(19), 8988-98.
			3'-PROCESSING	Integrase	>	100	uM			18805696	DISCOVERY OF 3-ACETYL-4-HYDROXY-2-PYRANONE DERIVATIVES AND THEIR DIFLUORIDOBORATE COMPLEXES AS A NOVEL CLASS OF HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry 2008, 16(19), 8988-98.
	HIV-1		STRAND TRANSFER	Integrase		0.015	uM			19523819	N-(4-FLUOROBENZYL)-3-HYDROXY-9;9-DIMETHYL-4-OXO-6;7;8;9-TETRAHYDRO-4H-PYRAZINO[1;2-A]PYRIMIDINE-2-CARBOXAMIDES A NOVEL CLASS OF POTENT HIV-1 INTEGRASE INHIBITORS. Bioorganic & Medical Chemistry Letters 2009, 19, 4245-9.
	HIV-1		HPLC	Protease		5.8	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ASSAY	Reverse transcriptase		170.3	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		HPLC	Protease		10.2	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ASSAY	Reverse transcriptase		33.7	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		HPLC	Protease		24.9	uM			18543149	INHIBITION OF HIV-1 PROTEASE AND RNASE H OF HIV-1 REVERSE TRANSCRIPTASE ACTIVITIES BY LONG CHAIN PHENOLS FROM THE SARCOTESTAS OF GINKGO BILOBA. Planta Medica 2008, 74(5), 532-534.
	HIV-1		3'-processing	Integrase	>	100	uM				COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS. . Patent 2009, , .
	HIV-1		Strand Transfer	Integrase	>	100	uM				COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS. . Patent 2009, , .
	HIV-1		3'-processing	Integrase	>	100	uM				COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS. . Patent 2009, , .

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：KB

External ID: CHEMBL836410

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2005
Volume: 48
Issue: 9
First Page: 3130
Last Page: 3140
DOI: 10.1021/jm040132t

Target ChEMBL ID: CHEMBL398
ChEMBL Target Name: KB
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
137	LD50	=	137	uM
218	LD50	=	218	uM
1099	LD50	>	1099	uM
892	LD50	>	892	uM
746	LD50	>	746	uM
255	LD50	=	255	uM
107	LD50	=	107	uM
782	LD50	=	782	uM
1082	LD50	>	1082	uM
1119	LD50	>	1119	uM
1055	LD50	>	1055	uM
465	LD50	=	465	uM
13.9	LD50	=	13.9	uM
931	LD50	>	931	uM
91	LD50	=	91	uM
844	LD50	>	844	uM
354	LD50	=	354	uM
260	LD50	=	260	uM
499	LD50	=	499	uM
212	LD50	=	212	uM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Osteoclast

External ID: CHEMBL2026328

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2012
Volume: 52
First Page: 221
Last Page: 229
DOI: 10.1016/j.ejmech.2012.03.020

Target ChEMBL ID: CHEMBL612548
ChEMBL Target Name: Osteoclast
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Activity Comment
Activity	Active
Activity	Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Replicase polyprotein 1ab

External ID: CHEMBL4495582

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4523582
ChEMBL Target Name: Replicase polyprotein 1ab
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	13.77	%
Inhibition	=	2.35	%
Inhibition	=	21.17	%
Inhibition	=	18.36	%
Inhibition	=	5.381	%
Inhibition	=	18.17	%
Inhibition	=	10.15	%
Inhibition	=	29.56	%
Inhibition	=	18.27	%
Inhibition	=	11.42	%
Inhibition	=	15.4	%
Inhibition	=	7.437	%
Inhibition	=	-3.216	%
Inhibition	=	18	%
Inhibition	=	1.021	%
Inhibition	=	16.4	%
Inhibition	=	2.544	%
Inhibition	=	19.11	%
Inhibition	=	26.15	%
Inhibition	=	5.133	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL850290

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 14
First Page: 2904
Last Page: 2914
DOI: 10.1021/jm0102809

Standard Type	Standard Relation	Standard Value
TI	<	2
TI	=	267
TI	=	5
TI	>	19
TI	>	38
TI	=	29
TI	=	246
TI	>	16
TI	=	63
TI	=	21
TI	>	195
TI	=	13
TI	>	23
TI	>	473
TI	>	11
TI	=	24
TI	>	10
TI	>	11
TI	=	10

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histone deacetylase 6

External ID: CHEMBL4808149

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1865
ChEMBL Target Name: Histone deacetylase 6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: Fraunhofer Institute HDAC6 screening

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
Inhibition	=	-13.63	%	Outside typical range
Inhibition	=	-37.85	%	Outside typical range
Inhibition	=	-31.68	%	Outside typical range
Inhibition	=	-40.84	%	Outside typical range
Inhibition	=	-33.51	%	Outside typical range
Inhibition	=	-11.71	%	Outside typical range
Inhibition	=	-12.48	%	Outside typical range
Inhibition	=	8.75	%
Inhibition	=	-57.22	%	Outside typical range
Inhibition	=	-43.91	%	Outside typical range
Inhibition	=	-42.06	%	Outside typical range
Inhibition	=	25.26	%
Inhibition	=	31.78	%
Inhibition	=	-63.83	%	Outside typical range
Inhibition	=	1.14	%
Inhibition	=	-17.63	%	Outside typical range
Inhibition	=	14.49	%
Inhibition	=	3.28	%
Inhibition	=	10.08	%
Inhibition	=	13.93	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Plasmodium falciparum

External ID: CHEMBL769481

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J Med Chem
Year: 2004
Volume: 47
Issue: 1
First Page: 175
Last Page: 187
DOI: 10.1021/jm030084x

Target ChEMBL ID: CHEMBL364
ChEMBL Target Name: Plasmodium falciparum
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
18.4	IC50	=	18400	nM
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
28.8	IC50	=	28800	nM
2.12	IC50	=	2120	nM
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
0.83	IC50	=	830	nM
158	IC50	=	158000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
197	IC50	=	197000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
1.07	IC50	=	1070	nM
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range
200	IC50	>	200000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Histone deacetylase 6

External ID: CHEMBL4808150

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL1865
ChEMBL Target Name: Histone deacetylase 6
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: Fraunhofer Institute HDAC6 screening

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	-7.39	%
Inhibition	=	-3.08	%
Inhibition	=	97.8	%
Inhibition	=	-9.09	%
Inhibition	=	47.05	%
Inhibition	=	-5.94	%
Inhibition	=	-0.48	%
Inhibition	=	-2.98	%
Inhibition	=	1.42	%
Inhibition	=	12.25	%
Inhibition	=	-2.13	%
Inhibition	=	-4.43	%
Inhibition	=	4.53	%
Inhibition	=	-5.82	%
Inhibition	=	10.36	%
Inhibition	=	-1.3	%
Inhibition	=	12.9	%
Inhibition	=	-3.37	%
Inhibition	=	3.17	%
Inhibition	=	-0.97	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma brucei rhodesiense

External ID: CHEMBL817404

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2002
Volume: 45
Issue: 14
First Page: 2904
Last Page: 2914
DOI: 10.1021/jm0102809

Target ChEMBL ID: CHEMBL612348
ChEMBL Target Name: Trypanosoma brucei rhodesiense
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
40	IC50	=	40000	nM
8	IC50	=	8000	nM
20.5	IC50	=	20500	nM
19.8	IC50	=	19800	nM
8.6	IC50	=	8600	nM
0.22	IC50	=	220	nM
21.3	IC50	=	21300	nM
31.7	IC50	=	31700	nM
5.4	IC50	=	5400	nM
50.6	IC50	=	50600	nM
1.7	IC50	=	1700	nM
102	IC50	=	102000	nM	Outside typical range
34.4	IC50	=	34400	nM
8.6	IC50	=	8600	nM
99.8	IC50	=	99800	nM
92	IC50	=	92000	nM
0.96	IC50	=	960	nM
39.5	IC50	=	39500	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Farnesyl pyrophosphate synthase

External ID: CHEMBL681890

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 24
First Page: 5171
Last Page: 5183
DOI: 10.1021/jm0302344

Target ChEMBL ID: CHEMBL1782
ChEMBL Target Name: Farnesyl diphosphate synthase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.18	IC50	=	180	nM
43	IC50	=	43000	nM
0.51	IC50	=	510	nM
6.5	IC50	=	6500	nM
3.4	IC50	=	3400	nM
2.4	IC50	=	2400	nM
1.3	IC50	=	1300	nM
0.17	IC50	=	170	nM
7.8	IC50	=	7800	nM
5.9	IC50	=	5900	nM
1.3	IC50	=	1300	nM
0.16	IC50	=	160	nM
0.25	IC50	=	250	nM
76	IC50	=	76000	nM
3.2	IC50	=	3200	nM
0.21	IC50	=	210	nM
0.5	IC50	=	500	nM
4.6	IC50	=	4600	nM
1.9	IC50	=	1900	nM
0.16	IC50	=	160	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Farnesyl pyrophosphate synthase

External ID: CHEMBL857167

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 24
First Page: 5171
Last Page: 5183
DOI: 10.1021/jm0302344

Target ChEMBL ID: CHEMBL1782
ChEMBL Target Name: Farnesyl diphosphate synthase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.18197	IC50	=	181.97	nM
43.6516	IC50	=	43651.58	nM
0.51286	IC50	=	512.86	nM
6.45654	IC50	=	6456.54	nM
3.38844	IC50	=	3388.44	nM
2.34423	IC50	=	2344.23	nM
1.34896	IC50	=	1348.96	nM
0.16982	IC50	=	169.82	nM
7.76247	IC50	=	7762.47	nM
5.88844	IC50	=	5888.44	nM
1.28825	IC50	=	1288.25	nM
0.15849	IC50	=	158.49	nM
0.25119	IC50	=	251.19	nM
75.8578	IC50	=	75857.76	nM
3.23594	IC50	=	3235.94	nM
0.20893	IC50	=	208.93	nM
0.48978	IC50	=	489.78	nM
4.57088	IC50	=	4570.88	nM
1.86209	IC50	=	1862.09	nM
0.15849	IC50	=	158.49	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Farnesyl pyrophosphate synthase

External ID: CHEMBL681891

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2003
Volume: 46
Issue: 24
First Page: 5171
Last Page: 5183
DOI: 10.1021/jm0302344

Target ChEMBL ID: CHEMBL1782
ChEMBL Target Name: Farnesyl diphosphate synthase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.017	Ki	=	17	nM
4.2	Ki	=	4200	nM
0.049	Ki	=	49	nM
0.62	Ki	=	620	nM
0.33	Ki	=	330	nM
0.23	Ki	=	230	nM
0.13	Ki	=	130	nM
0.016	Ki	=	16	nM
0.74	Ki	=	740	nM
0.56	Ki	=	560	nM
0.12	Ki	=	120	nM
0.015	Ki	=	15	nM
0.024	Ki	=	24	nM
7.3	Ki	=	7300	nM
0.3	Ki	=	300	nM
0.02	Ki	=	20	nM
0.047	Ki	=	47	nM
0.44	Ki	=	440	nM
0.18	Ki	=	180	nM
0.016	Ki	=	16	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A

External ID: ULK1_INH_LUMI_1536_1X%INH PRUN

Protocol: Assay Overview:

The purpose of this biochemical assay is to identify compounds that act as inhibitors of Unc-51 Like Autophagy Activating Kinase 1 (ULK1). In this assay, ULK1 enzyme is incubated with test compounds and Atg13 and ATP to start the reaction. ULK1 specifically phosphorylates the Atg13 avidin tagged fusion protein. Phosphoryated Atg13 is then targeted by the anti-phospho Atg13 Ab. Rabbit IgG acceptor beads then recognize this complex. Streptavidin coated donor beads recognize the avidin tag from the Atg13 fusion protein. As designed, test compounds that act as ULK1 inhibitors in the presence of ATP will prevent the phosphorylation of Atg13, thereby leading to decreased luminescence signal from the beads. Compounds are tested in singlicate at a nominal test concentration of 5.96 micromolar.

Protocol Summary:
Prior to the start of the assay, 2 microliters of assay buffer (50mM Tris-Cl pH7.5, 20mM Magnesium chloride, 1mM DTT, 0.01% Triton X-100, 0.01% DMSO and 0.1mg/mL BSA) were dispensed into columns 1 thru column 3 of 1536 microtiter plates. Next, 2 microliters of assay buffer containing 2.5nM of ULK1 enzyme were dispensed into columns 4 thru column 48. Then, 30 nL of test compound in DMSO, Staurosporine (33uM final highest concentration) in DMSO, or DMSO alone (0.6% final concentration) were added to the appropriate wells and incubated for 15 minutes at 25 degrees Celsius. The assay was started by dispensing 1 microliter of assay buffer containing 100nM of Atg13 and 100uM of ATP to all wells. Plates were centrifuged and incubated for 120 minutes at 25 degrees Celsius. Next, 1 microliter of anti-pAtg13 (Final 0.5nM), EDTA (Final 20mM) and Anti-Rabbit IgG Acceptor beads (Final 16ug/mL) in 1X AlphaLISA detection buffer were dispensed into all wells. Plates were centrifuged and incubated for 60 minutes at 25 degrees Celsius. Then, 1 microliter of Streptavidin Donor Beads (Final 32ug/mL) was dispensed into all wells. Plates were centrifuged and incubated for 60 minutes at 25 degrees Celsius. Alphascreen signal was determined using an EnVision microplate reader ((PerkinElmer, Turku, Finland) at 680nm excitation and 570nm emission.

The percent inhibition for each compound was calculated as follows:

100 *( ( Test_Compound - Median_Low_Control ) / ( Median_High_Control - Median_Low_Control ) )

Where:

Test_Compound is defined as wells containing ULK1 enzyme +Atg13/ATP in the presence of test compound
High_Control is defined as wells containing assay buffer (no enzyme) + Atg13/ATP and DMSO.
Low_Control is defined as the median of the wells containing test compounds.

PubChem Activity Outcome and Score:

Interval Cutoff

The reported PubChem Activity Score has been normalized to 100% observed primary inhibition. Negative % inhibition values are reported as activity score zero.

The activity score range for active compounds is 100-1, for inactive 1-0.

List of Reagents:

ULK1 enzyme (Sigma, part SRP0252-supplied by Derek Duckett)
Biotinylated-Atg13 (supplied by Derek Duckett)
Staurosporine (Enzo, part ALX-380-014)
Tris (Amresco, part 0497)
Magnesium chloride (Sigma, part M0631)
ATP (Sigma, part A6419)
DTT (Fisher, part BP172)
Triton X-100 (Sigma, part T9284)
DMSO (Fisher, part D159)
BSA (Calbiochem, part 126609)
EDTA (Fisher, part BP2482)
Anti-Atg13 pS318 Antibody (Rockland, part 600-401-C49)
AlphaScreen Rabbit IgG Detection Kit (Perkin Elmer, part 6760607M)
1536-well plates (Corning, part 7254)

Comment: Due to the size of the Scripps Molecular Screening Center compound library, this assay may have been run as two or more separate campaigns, each campaign testing a unique set of compounds. All data reported were normalized on a per-plate basis. Possible artifacts of this assay can include, but are not limited to: dust or lint located in or on wells of the microtiter plate, compounds that modulate well fluorescence. All test compound concentrations reported above and below are nominal; the specific test concentration(s) for a particular compound may vary based upon the actual sample provided by the Scripps Molecular Screening Center.

Inhibition at 5.96 uM
22.35
22.25
22.13
22.12
21.66
21.27
21.26
20.92
20.86
20.64
20.53
20.47
20.41
20.16
20.16
20.1
20.02
19.97
19.73
19.69

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanosoma brucei

External ID: CHEMBL808707

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 2001
Volume: 44
Issue: 6
First Page: 909
Last Page: 916
DOI: 10.1021/jm0002578

Target ChEMBL ID: CHEMBL612849
ChEMBL Target Name: Trypanosoma brucei
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
40	IC50	=	40000	nM
7.8	IC50	=	7800	nM
19.8	IC50	=	19800	nM
200	IC50	>	200000	nM	Outside typical range
0.22	IC50	=	220	nM
21.3	IC50	=	21300	nM
31.7	IC50	=	31700	nM
5.4	IC50	=	5400	nM
1.7	IC50	=	1700	nM
27.9	IC50	=	27900	nM
99.8	IC50	=	99800	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Escherichia coli

External ID: CHEMBL910461

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2006
Volume: 49
Issue: 25
First Page: 7331
Last Page: 7341
DOI: 10.1021/jm060492b

Target ChEMBL ID: CHEMBL354
ChEMBL Target Name: Escherichia coli
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	24	mm
IZ	=	9	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	13	mm
IZ	=	9	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	7	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Type IV secretion-like conjugative transfer relaxase protein TraI

External ID: CHEMBL921469

Protocol: N/A

Comment: Journal: Proc. Natl. Acad. Sci. U.S.A.
Year: 2007
Volume: 104
Issue: 30
First Page: 12282
Last Page: 12287
DOI: 10.1073/pnas.0702760104

Target ChEMBL ID: CHEMBL4296318
ChEMBL Target Name: Type IV secretion-like conjugative transfer relaxase protein TraI
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Type IV secretion-like conjugative transfer relaxase protein TraI

External ID: CHEMBL921470

Protocol: N/A

Comment: Journal: Proc. Natl. Acad. Sci. U.S.A.
Year: 2007
Volume: 104
Issue: 30
First Page: 12282
Last Page: 12287
DOI: 10.1073/pnas.0702760104

Target ChEMBL ID: CHEMBL4296318
ChEMBL Target Name: Type IV secretion-like conjugative transfer relaxase protein TraI
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
Activity	Active
Activity	Not Active
Activity	Active
Activity	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Collagenase ColQ1

External ID: CHEMBL5106982

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2022
Volume: 65
Issue: 19.0
First Page: 12933
Last Page: 12955
DOI: 10.1021/acs.jmedchem.2c00785

Target ChEMBL ID: CHEMBL5169213
ChEMBL Target Name: Collagenase ColQ1
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	76	%
Inhibition	<	5	%
Inhibition	<	5	%
Inhibition	=	63	%
Inhibition	<	5	%
Inhibition	<	5	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL808362

Protocol: N/A

Comment: Journal: J Med Chem
Year: 2002
Volume: 45
Issue: 17
First Page: 3721
Last Page: 3738
DOI: 10.1021/jm020819i

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
ED50	=	0.061	mg.kg-1
ED50	=	0.008	mg.kg-1
ED50	=	0.04	mg.kg-1
ED50	=	0.8	mg.kg-1
ED50	=	0.06	mg.kg-1
ED50	=	0.012	mg.kg-1
ED50	>	3	mg.kg-1
ED50	=	0.007	mg.kg-1
ED50	=	0.1	mg.kg-1
ED50	=	4.0E-4	mg.kg-1	Outside typical range
ED50	=	0.0011	mg.kg-1
ED50	=	0.003	mg.kg-1
ED50	=	0.005	mg.kg-1
ED50	=	5.0E-4	mg.kg-1
ED50	>	3	mg.kg-1
ED50	~	0.015	mg.kg-1
ED50	>	0.2	mg.kg-1
ED50	=	0.15	mg.kg-1
ED50	=	7.0E-5	mg.kg-1	Outside typical range

Standard Type	Standard Relation	Standard Value
TI	<	2
TI	=	267
TI	=	5
TI	>	19
TI	>	38
TI	=	29
TI	=	246
TI	>	16
TI	=	63
TI	=	21
TI	>	195
TI	=	13
TI	>	23
TI	>	473
TI	>	11
TI	=	24
TI	>	10
TI	>	11
TI	=	10

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	24	mm
IZ	=	9	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	13	mm
IZ	=	9	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	7	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm

Standard Type	Standard Relation	Standard Value
TI	<	2
TI	=	267
TI	=	5
TI	>	19
TI	>	38
TI	=	29
TI	=	246
TI	>	16
TI	=	63
TI	=	21
TI	>	195
TI	=	13
TI	>	23
TI	>	473
TI	>	11
TI	=	24
TI	>	10
TI	>	11
TI	=	10

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	24	mm
IZ	=	9	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	13	mm
IZ	=	9	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	7	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm

79778-41-9 靶点实验数据

Standard Type	Standard Relation	Standard Value
TI	<	2
TI	=	267
TI	=	5
TI	>	19
TI	>	38
TI	=	29
TI	=	246
TI	>	16
TI	=	63
TI	=	21
TI	>	195
TI	=	13
TI	>	23
TI	>	473
TI	>	11
TI	=	24
TI	>	10
TI	>	11
TI	=	10

Standard Type	Standard Relation	Standard Value	Standard Units
IZ	=	24	mm
IZ	=	9	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	13	mm
IZ	=	9	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	7	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm
IZ	=	0	mm