HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Leishmania major

External ID: CHEMBL3762221

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 108
First Page: 436
Last Page: 443
DOI: 10.1016/j.ejmech.2015.11.023

Target ChEMBL ID: CHEMBL612879
ChEMBL Target Name: Leishmania major
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
84	IC50	=	84000	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
9.3	IC50	=	9300	nM
69.2	IC50	=	69200	nM
100	IC50	>	100000	nM
43.3	IC50	=	43300	nM
7.6	IC50	=	7600	nM
100	IC50	>	100000	nM
100	IC50	>	100000	nM
15.7	IC50	=	15700	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1664801

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	1	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	512	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	1	ug.mL-1
MIC	=	256	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	4	ug.mL-1
Activity				Not Active
MIC	=	0.06	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Exophiala spinifera

External ID: CHEMBL1664802

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL615083
ChEMBL Target Name: Exophiala spinifera
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	1	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	0.06	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	256	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	16	ug.mL-1
Activity				Not Active
MIC	=	0.06	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1664803

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	1	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	0.06	ug.mL-1
MIC	=	4	ug.mL-1
MIC	=	512	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	16	ug.mL-1
Activity				Not Active
MIC	=	0.125	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1664804

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	1	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	0.06	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	512	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	16	ug.mL-1
Activity				Not Active
MIC	=	0.06	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Tryparedoxin peroxidase

External ID: CHEMBL3762225

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 108
First Page: 436
Last Page: 443
DOI: 10.1016/j.ejmech.2015.11.023

Target ChEMBL ID: CHEMBL3758065
ChEMBL Target Name: Tryparedoxin peroxidase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Activity Comment
TDI	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanothione reductase

External ID: CHEMBL3762224

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 108
First Page: 436
Last Page: 443
DOI: 10.1016/j.ejmech.2015.11.023

Target ChEMBL ID: CHEMBL1837
ChEMBL Target Name: Trypanothione reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Activity Comment
TDI	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanothione reductase

External ID: CHEMBL3762223

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 108
First Page: 436
Last Page: 443
DOI: 10.1016/j.ejmech.2015.11.023

Target ChEMBL ID: CHEMBL1837
ChEMBL Target Name: Trypanothione reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：K562

External ID: CHEMBL3762222

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 108
First Page: 436
Last Page: 443
DOI: 10.1016/j.ejmech.2015.11.023

Target ChEMBL ID: CHEMBL385
ChEMBL Target Name: K562
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
	IC50				Not Determined
	IC50				Not Determined
6.44	IC50	=	6440	nM
5	IC50	=	5000	nM
30	IC50	>	30000	nM
4.8	IC50	=	4800	nM
3	IC50	=	3000	nM
	IC50				Not Determined
6.15	IC50	>	6150	nM
10.22	IC50	=	10220	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Pichia kudriavzevii

External ID: CHEMBL1664793

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL612841
ChEMBL Target Name: Pichia kudriavzevii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	0.25	ug.mL-1
MIC	=	64	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	0.06	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	512	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	32	ug.mL-1
Activity				Not Active
MIC	=	0.06	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Meyerozyma guilliermondii

External ID: CHEMBL1664794

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL612843
ChEMBL Target Name: Meyerozyma guilliermondii
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	1	ug.mL-1
MIC	=	4	ug.mL-1
MIC	=	512	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	1	ug.mL-1
MIC	=	256	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	32	ug.mL-1
Activity				Not Active
MIC	=	0.5	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanothione reductase

External ID: CHEMBL3762227

Protocol: N/A

Comment: Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 108
First Page: 436
Last Page: 443
DOI: 10.1016/j.ejmech.2015.11.023

Target ChEMBL ID: CHEMBL1837
ChEMBL Target Name: Trypanothione reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

Standard Type	Standard Units	Activity Comment
Inhibition	%	Not Active
Inhibition	%	Not Active

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Cryptococcus neoformans

External ID: CHEMBL1664795

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL365
ChEMBL Target Name: Cryptococcus neoformans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	0.5	ug.mL-1
MIC	=	8	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	256	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	8	ug.mL-1
Activity				Not Active
MIC	=	0.25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Trypanothione reductase

External ID: CHEMBL3762226

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur. J. Med. Chem.
Year: 2016
Volume: 108
First Page: 436
Last Page: 443
DOI: 10.1016/j.ejmech.2015.11.023

Target ChEMBL ID: CHEMBL1837
ChEMBL Target Name: Trypanothione reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
7.6	IC50	=	7600	nM
7.2	IC50	=	7200	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：NON-PROTEIN TARGET

External ID: CHEMBL1664796

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL3879801
ChEMBL Target Name: NON-PROTEIN TARGET
ChEMBL Target Type: NON-MOLECULAR - Target has not been defined at a molecular level, only the non-molecular entity which is affected (e.g., organism, cell line etc)
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	0.5	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	>	512	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	16	ug.mL-1
Activity				Not Active
MIC	=	0.25	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus flavus

External ID: CHEMBL1664797

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL614955
ChEMBL Target Name: Aspergillus flavus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	0.25	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	0.25	ug.mL-1
MIC	=	1	ug.mL-1
MIC	>	512	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	32	ug.mL-1
Activity				Not Active
MIC	=	0.125	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus niger

External ID: CHEMBL1664798

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL358
ChEMBL Target Name: Aspergillus niger
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	0.5	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	0.125	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	>	512	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	2	ug.mL-1
Activity				Not Active
MIC	=	0.125	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Aspergillus terreus

External ID: CHEMBL1664800

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL612277
ChEMBL Target Name: Aspergillus terreus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	2	ug.mL-1
MIC	=	16	ug.mL-1
MIC	=	256	ug.mL-1
MIC	=	0.06	ug.mL-1
MIC	=	1	ug.mL-1
MIC	>	512	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	16	ug.mL-1
Activity				Not Active
MIC	=	0.125	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida albicans

External ID: CHEMBL1664790

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL366
ChEMBL Target Name: Candida albicans
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	0.5	ug.mL-1
MIC	=	2	ug.mL-1
MIC	>	512	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	2	ug.mL-1
MIC	=	256	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	32	ug.mL-1
Activity				Not Active
MIC	=	0.125	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Candida parapsilosis

External ID: CHEMBL1664791

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL612868
ChEMBL Target Name: Candida parapsilosis
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	0.5	ug.mL-1
MIC	=	1	ug.mL-1
MIC	=	512	ug.mL-1
MIC	=	0.06	ug.mL-1
MIC	=	0.5	ug.mL-1
MIC	=	256	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	=	32	ug.mL-1
Activity				Not Active
MIC	=	0.125	ug.mL-1

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Nakaseomyces glabratus

External ID: CHEMBL1664792

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2011
Volume: 46
Issue: 1
First Page: 101
Last Page: 105
DOI: 10.1016/j.ejmech.2010.10.019

Target ChEMBL ID: CHEMBL612647
ChEMBL Target Name: Nakaseomyces glabratus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
MIC	=	0.25	ug.mL-1
MIC	=	1	ug.mL-1
MIC	>	512	ug.mL-1
MIC	=	0.06	ug.mL-1
MIC	=	1	ug.mL-1
MIC	=	256	ug.mL-1
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
Activity				Not Active
MIC	>	512	ug.mL-1
Activity				Not Active
MIC	=	0.25	ug.mL-1

786-50-5 靶点实验数据