HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDA-MB-468

External ID: CHEMBL4821860

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2021
Volume: 219
First Page: 113424
Last Page: 113424
DOI: 10.1016/j.ejmech.2021.113424

Target ChEMBL ID: CHEMBL614335
ChEMBL Target Name: MDA-MB-468
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
31.94	IC50	=	31940	nM
13.07	IC50	=	13070	nM
25.95	IC50	=	25950	nM
8.46	IC50	=	8460	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Serine/threonine-protein kinase mTOR

External ID: CHEMBL4821861

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2021
Volume: 219
First Page: 113424
Last Page: 113424
DOI: 10.1016/j.ejmech.2021.113424

Target ChEMBL ID: CHEMBL2842
ChEMBL Target Name: Serine/threonine-protein kinase mTOR
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
16.88	IC50	=	16880	nM
6.21	IC50	=	6210	nM
15.27	IC50	=	15270	nM
2.01	IC50	=	2010	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：A549

External ID: CHEMBL4821858

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2021
Volume: 219
First Page: 113424
Last Page: 113424
DOI: 10.1016/j.ejmech.2021.113424

Target ChEMBL ID: CHEMBL392
ChEMBL Target Name: A549
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
33.05	IC50	=	33050	nM
13.04	IC50	=	13040	nM
26.37	IC50	=	26370	nM
10.07	IC50	=	10070	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDA-MB-231

External ID: CHEMBL4821859

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Eur J Med Chem
Year: 2021
Volume: 219
First Page: 113424
Last Page: 113424
DOI: 10.1016/j.ejmech.2021.113424

Target ChEMBL ID: CHEMBL400
ChEMBL Target Name: MDA-MB-231
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
34.06	IC50	=	34060	nM
10.86	IC50	=	10860	nM
32.12	IC50	=	32120	nM
6.71	IC50	=	6710	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：MDA-MB-231

External ID: CHEMBL4821862

Protocol: N/A

Comment: Journal: Eur J Med Chem
Year: 2021
Volume: 219
First Page: 113424
Last Page: 113424
DOI: 10.1016/j.ejmech.2021.113424

Target ChEMBL ID: CHEMBL400
ChEMBL Target Name: MDA-MB-231
ChEMBL Target Type: CELL-LINE - Target is a specific cell-line
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value	Standard Units
Activity	=	31.03	%
Activity	=	15.33	%
Activity	=	11.22	%
Activity	=	9.25	%

784159-17-7 靶点实验数据