HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 1

External ID: CHEMBL774473

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 8
First Page: 2296
Last Page: 2304
DOI: 10.1021/jm00170a039

Target ChEMBL ID: CHEMBL2095157
ChEMBL Target Name: Cyclooxygenase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Change	=	-29	%
Change	=	-24	%
Change	=	-27	%
Change	=	-23	%
Change	=	-2	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL793141

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 8
First Page: 2296
Last Page: 2304
DOI: 10.1021/jm00170a039

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Therapeutic index	=	1
Therapeutic index	=	1.6
Therapeutic index	=	0.4
Therapeutic index	=	10

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Rattus norvegicus

External ID: CHEMBL794150

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1990
Volume: 33
Issue: 8
First Page: 2296
Last Page: 2304
DOI: 10.1021/jm00170a039

Target ChEMBL ID: CHEMBL376
ChEMBL Target Name: Rattus norvegicus
ChEMBL Target Type: ORGANISM - Target is a complete organism
Relationship Type: N - Non-molecular target assigned
Confidence: Target assigned is non-molecular

Standard Type	Standard Relation	Standard Value
Potency	=	1
Potency	=	2.2
Potency	=	0.3
Potency	=	0.8
Potency	=	0.09

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL812588

Protocol: N/A

Comment: Journal: J Med Chem
Year: 1990
Volume: 33
Issue: 8
First Page: 2296
Last Page: 2304
DOI: 10.1021/jm00170a039

Standard Type	Standard Relation	Standard Value
Potency	=	1.4
Potency	=	0.7
Potency	=	0.08

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 1

External ID: CHEMBL776002

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 8
First Page: 2296
Last Page: 2304
DOI: 10.1021/jm00170a039

Target ChEMBL ID: CHEMBL2095157
ChEMBL Target Name: Cyclooxygenase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value	Standard Units
Change	=	-33	%
Change	=	-25	%
Change	=	-32	%
Change	=	-37	%
Change	=	-30	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Prostaglandin G/H synthase 1

External ID: CHEMBL769240

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1990
Volume: 33
Issue: 8
First Page: 2296
Last Page: 2304
DOI: 10.1021/jm00170a039

Target ChEMBL ID: CHEMBL2095157
ChEMBL Target Name: Cyclooxygenase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range
73	IC50	=	73000	nM
1000	IC50	>	1000000	nM	Outside typical range
1000	IC50	>	1000000	nM	Outside typical range

78281-73-9 靶点实验数据