HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL3767073

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 5
First Page: 1406
Last Page: 1410
DOI: 10.1016/j.bmcl.2016.01.072

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
310	Ki	=	310000	nM	Outside typical range
0.5	Ki	=	500	nM
31700	Ki	=	31700000	nM	Outside typical range
1.2	Ki	=	1200	nM
63000	Ki	=	63000000	nM	Outside typical range
25800	Ki	=	25800000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
8400	Ki	=	8400000	nM	Outside typical range
200	Ki	=	200000	nM	Outside typical range
18000	Ki	=	18000000	nM	Outside typical range
0.7	Ki	=	700	nM
0.6	Ki	=	600	nM
7000	Ki	=	7000000	nM	Outside typical range
8.7	Ki	=	8700	nM
4000	Ki	=	4000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
300	Ki	=	300000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3767076

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2016
Volume: 26
Issue: 5
First Page: 1406
Last Page: 1410
DOI: 10.1016/j.bmcl.2016.01.072

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
86	Ki	=	86000	nM
54	Ki	=	54000	nM
5700	Ki	=	5700000	nM	Outside typical range
79	Ki	=	79000	nM
20500	Ki	=	20500000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
15100	Ki	=	15100000	nM	Outside typical range
6700	Ki	=	6700000	nM	Outside typical range
5900	Ki	=	5900000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
9100	Ki	=	9100000	nM	Outside typical range
9500	Ki	=	9500000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
7100	Ki	=	7100000	nM	Outside typical range
21300	Ki	=	21300000	nM	Outside typical range
8400	Ki	=	8400000	nM	Outside typical range
7000	Ki	=	7000000	nM	Outside typical range
7400	Ki	=	7400000	nM	Outside typical range
8100	Ki	=	8100000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3767075

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 5
First Page: 1406
Last Page: 1410
DOI: 10.1016/j.bmcl.2016.01.072

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8	Ki	=	8000	nM
33	Ki	=	33000	nM
23	Ki	=	23000	nM
760	Ki	=	760000	nM	Outside typical range
850	Ki	=	850000	nM	Outside typical range
2960	Ki	=	2960000	nM	Outside typical range
4640	Ki	=	4640000	nM	Outside typical range
5130	Ki	=	5130000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
34100	Ki	=	34100000	nM	Outside typical range
820	Ki	=	820000	nM	Outside typical range
68	Ki	=	68000	nM
75	Ki	=	75000	nM
74	Ki	=	74000	nM
670	Ki	=	670000	nM	Outside typical range
88	Ki	=	88000	nM
28000	Ki	=	28000000	nM	Outside typical range
930	Ki	=	930000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range
9730	Ki	=	9730000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 13

External ID: CHEMBL841782

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2004
Volume: 14
Issue: 21
First Page: 5435
Last Page: 5439
DOI: 10.1016/j.bmcl.2004.07.086

Target ChEMBL ID: CHEMBL2186
ChEMBL Target Name: Carbonic anhydrase XIII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3000	Ki	=	3000000	nM	Manually validated
5400	Ki	=	5400000	nM	Outside typical range
2850	Ki	=	2850000	nM	Outside typical range
21500	Ki	=	21500000	nM	Outside typical range
740	Ki	=	740000	nM	Manually validated
140	Ki	=	140000	nM	Outside typical range
36000	Ki	=	36000000	nM	Outside typical range
5200	Ki	=	5200000	nM	Outside typical range
60	Ki	=	60000	nM
3000	Ki	=	3000000	nM	Manually validated
45000	Ki	=	45000000	nM	Manually validated
5400	Ki	=	5400000	nM	Outside typical range
5500	Ki	=	5500000	nM	Manually validated
12600	Ki	=	12600000	nM	Manually validated
75500	Ki	=	75500000	nM	Manually validated
0.25	Ki	=	250	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3767074

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2016
Volume: 26
Issue: 5
First Page: 1406
Last Page: 1410
DOI: 10.1016/j.bmcl.2016.01.072

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1130	Ki	=	1130000	nM	Outside typical range
20	Ki	=	20000	nM
49200	Ki	=	49200000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
1600	Ki	=	1600000	nM	Outside typical range
89000	Ki	=	89000000	nM	Outside typical range
30	Ki	=	30000	nM
40	Ki	=	40000	nM
35000	Ki	=	35000000	nM	Outside typical range
8.8	Ki	=	8800	nM
63000	Ki	=	63000000	nM	Outside typical range
200000	Ki	=	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2342885

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1626
Last Page: 1630
DOI: 10.1016/j.bmcl.2013.01.087

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7.4	Ki	=	7400	nM
800	Ki	=	800000	nM	Outside typical range
650	Ki	=	650000	nM	Outside typical range
72	Ki	=	72000	nM
500	Ki	=	500000	nM	Outside typical range
92	Ki	=	92000	nM
420	Ki	=	420000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
670	Ki	=	670000	nM	Outside typical range
480	Ki	=	480000	nM	Outside typical range
450	Ki	=	450000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
930	Ki	=	930000	nM	Outside typical range
750	Ki	=	750000	nM	Outside typical range
180	Ki	=	180000	nM	Outside typical range
680	Ki	=	680000	nM	Outside typical range
630	Ki	=	630000	nM	Outside typical range
700	Ki	=	700000	nM	Outside typical range
540	Ki	=	540000	nM	Outside typical range
580	Ki	=	580000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL876781

Protocol: N/A

Comment: Journal: Bioorg Med Chem Lett
Year: 2004
Volume: 14
Issue: 17
First Page: 4563
Last Page: 4567
DOI: 10.1016/j.bmcl.2004.06.073

Target ChEMBL ID: CHEMBL3932
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
200000	Ki	>	200000000	nM	Outside typical range
160000	Ki	=	160000000	nM	Outside typical range
230	Ki	=	230000	nM	Outside typical range
9600	Ki	=	9600000	nM	Outside typical range
7000	Ki	=	7000000	nM	Outside typical range
70	Ki	=	70000	nM
36500	Ki	=	36500000	nM	Outside typical range
50	Ki	=	50000	nM
90	Ki	=	90000	nM
680	Ki	=	680000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
160000	Ki	=	160000000	nM	Outside typical range
160000	Ki	=	160000000	nM	Outside typical range
42000	Ki	=	42000000	nM	Outside typical range
6700	Ki	=	6700000	nM	Outside typical range
6800	Ki	=	6800000	nM	Outside typical range
150	Ki	=	150000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 7

External ID: CHEMBL860093

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2006
Volume: 16
Issue: 12
First Page: 3139
Last Page: 3143
DOI: 10.1016/j.bmcl.2006.03.078

Target ChEMBL ID: CHEMBL2326
ChEMBL Target Name: Carbonic anhydrase VII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
6.8	Ki	=	6800	nM
190	Ki	=	190000	nM	Outside typical range
9200	Ki	=	9200000	nM	Outside typical range
1410	Ki	=	1410000	nM	Outside typical range
12.5	Ki	=	12500	nM
1380	Ki	=	1380000	nM	Outside typical range
270	Ki	=	270000	nM	Outside typical range
160	Ki	=	160000	nM	Outside typical range
1780	Ki	=	1780000	nM	Outside typical range
7300	Ki	=	7300000	nM	Outside typical range
15200	Ki	=	15200000	nM	Outside typical range
1240	Ki	=	1240000	nM	Outside typical range
1060	Ki	=	1060000	nM	Outside typical range
1840	Ki	=	1840000	nM	Outside typical range
1240	Ki	=	1240000	nM	Outside typical range
250	Ki	=	250000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL839573

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 23
First Page: 5769
Last Page: 5773
DOI: 10.1016/j.bmcl.2004.09.063

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Ki	nM	Not Tested
Ki	nM	Not Tested
Ki	nM	Not Tested
Ki	nM	Not Tested

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2343319

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2013
Volume: 23
Issue: 6
First Page: 1626
Last Page: 1630
DOI: 10.1016/j.bmcl.2013.01.087

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
460	Ki	=	460000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
760	Ki	=	760000	nM	Potential transcription error
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2343318

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1626
Last Page: 1630
DOI: 10.1016/j.bmcl.2013.01.087

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
570	Ki	=	570000	nM	Outside typical range
8	Ki	=	8000	nM
460	Ki	=	460000	nM	Outside typical range
24500	Ki	=	24500000	nM	Outside typical range
4	Ki	=	4000	nM
660	Ki	=	660000	nM	Outside typical range
6	Ki	=	6000	nM
840	Ki	=	840000	nM	Outside typical range
620	Ki	=	620000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
530	Ki	=	530000	nM	Outside typical range
900	Ki	=	900000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
870	Ki	=	870000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
660	Ki	=	660000	nM	Outside typical range
860	Ki	=	860000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
50900	Ki	=	50900000	nM	Outside typical range
620	Ki	=	620000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3997502

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2017
Volume: 25
Issue: 6
First Page: 2010
Last Page: 2015
DOI: 10.1016/j.bmc.2017.02.032

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7100	Ki	=	7100000	nM	Outside typical range
320	Ki	=	320000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6500	Ki	=	6500000	nM	Outside typical range
89	Ki	=	89000	nM
3000	Ki	=	3000000	nM	Outside typical range
92	Ki	=	92000	nM
8600	Ki	=	8600000	nM	Outside typical range
8200	Ki	=	8200000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
12700	Ki	=	12700000	nM	Outside typical range
34100	Ki	=	34100000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
3400	Ki	=	3400000	nM	Outside typical range
15600	Ki	=	15600000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
13000	Ki	=	13000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL658044

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2003
Volume: 13
Issue: 5
First Page: 841
Last Page: 845
DOI: 10.1016/s0960-894x(03)00029-5

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.012	Ki	=	12	nM
97	Ki	=	97000	nM
100	Ki	>	100000	nM
21	Ki	=	21000	nM
0.071	Ki	=	71	nM
25	Ki	=	25000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL658045

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2003
Volume: 13
Issue: 5
First Page: 837
Last Page: 840
DOI: 10.1016/s0960-894x(03)00028-3

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.012	Ki	=	12	nM
82	Ki	=	82000	nM
0.017	Ki	=	17	nM
0.021	Ki	=	21	nM
0.011	Ki	=	11	nM
0.027	Ki	=	27	nM
0.015	Ki	=	15	nM
0.012	Ki	=	12	nM
0.036	Ki	=	36	nM
0.049	Ki	=	49	nM
0.032	Ki	=	32	nM
0.021	Ki	=	21	nM
0.016	Ki	=	16	nM
0.012	Ki	=	12	nM
0.131	Ki	=	131	nM
100	Ki	>	100000	nM
0.148	Ki	=	148	nM
0.123	Ki	=	123	nM
0.89	Ki	=	890	nM
0.45	Ki	=	450	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL2340480

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2013
Volume: 21
Issue: 6
First Page: 1379
Last Page: 1385
DOI: 10.1016/j.bmc.2013.01.019

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
8.86	Ki	=	8860	nM
3.09	Ki	=	3090	nM
1.28	Ki	=	1280	nM
1.07	Ki	=	1070	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 5B, mitochondrial

External ID: CHEMBL1118585

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL3969
ChEMBL Target Name: Carbonic anhydrase VB
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
84	Ki	=	84000	nM
0.075	Ki	=	75	nM
0.03	Ki	=	30	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL3595048

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

Target ChEMBL ID: CHEMBL3932
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment	Data Validity Comment
6800	Ki	=	6800000	nM		Outside typical range
	Ki				Not Determined
5800	Ki	=	5800000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
42000	Ki	=	42000000	nM		Outside typical range
	Ki				Not Determined
6700	Ki	=	6700000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
200000	Ki	>	200000000	nM		Outside typical range
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
	Ki				Not Determined
90	Ki	=	90000	nM
160000	Ki	=	160000000	nM		Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 5A, mitochondrial

External ID: CHEMBL1118584

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL4789
ChEMBL Target Name: Carbonic anhydrase VA
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
840	Ki	=	840000	nM	Outside typical range
0.087	Ki	=	87	nM
0.063	Ki	=	63	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3595049

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
3100	Ki	=	3100000	nM	Outside typical range
4	Ki	=	4000	nM
73	Ki	=	73000	nM
85500	Ki	=	85500000	nM	Outside typical range
9.2	Ki	=	9200	nM
960	Ki	=	960000	nM	Outside typical range
90	Ki	=	90000	nM
890	Ki	=	890000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
10800	Ki	=	10800000	nM	Outside typical range
16700	Ki	=	16700000	nM	Outside typical range
78900	Ki	=	78900000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range
910	Ki	=	910000	nM	Outside typical range
97	Ki	=	97000	nM
18500	Ki	=	18500000	nM	Outside typical range
71600	Ki	=	71600000	nM	Outside typical range
710	Ki	=	710000	nM	Outside typical range
8700	Ki	=	8700000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL1118583

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
0.88	Ki	=	880	nM
8.62	Ki	=	8620	nM
4.9	Ki	=	4900	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 3

External ID: CHEMBL1118582

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL2885
ChEMBL Target Name: Carbonic anhydrase III
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1090	Ki	=	1090000	nM	Outside typical range
8.77	Ki	=	8770	nM
780	Ki	=	780000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3595047

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
86	Ki	=	86000	nM
8.8	Ki	=	8800	nM
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1118581

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
1130	Ki	=	1130000	nM	Outside typical range
0.048	Ki	=	48	nM
0.01	Ki	=	10	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL1118580

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
310	Ki	=	310000	nM	Outside typical range
0.092	Ki	=	92	nM
0.25	Ki	=	250	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL852354

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 17
First Page: 4563
Last Page: 4567
DOI: 10.1016/j.bmcl.2004.06.073

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Standard Type	Standard Units	Activity Comment
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined
Ki	nM	Not Determined

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3595050

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8800	Ki	=	8800000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range
30500	Ki	=	30500000	nM	Outside typical range
8500	Ki	=	8500000	nM	Outside typical range
81	Ki	=	81000	nM
4500	Ki	=	4500000	nM	Outside typical range
84	Ki	=	84000	nM
2400	Ki	=	2400000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
5400	Ki	=	5400000	nM	Outside typical range
7700	Ki	=	7700000	nM	Outside typical range
9100	Ki	=	9100000	nM	Outside typical range
9500	Ki	=	9500000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
8900	Ki	=	8900000	nM	Outside typical range
7600	Ki	=	7600000	nM	Outside typical range
6400	Ki	=	6400000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
8900	Ki	=	8900000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3595051

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2015
Volume: 23
Issue: 15
First Page: 4405
Last Page: 4409
DOI: 10.1016/j.bmc.2015.06.021

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
6700	Ki	=	6700000	nM	Outside typical range
960	Ki	=	960000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6100	Ki	=	6100000	nM	Outside typical range
82	Ki	=	82000	nM
6200	Ki	=	6200000	nM	Outside typical range
87	Ki	=	87000	nM
2500	Ki	=	2500000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
6700	Ki	=	6700000	nM	Outside typical range
8500	Ki	=	8500000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
9100	Ki	=	9100000	nM	Outside typical range
7800	Ki	=	7800000	nM	Outside typical range
34600	Ki	=	34600000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range
8000	Ki	=	8000000	nM	Outside typical range
1700	Ki	=	1700000	nM	Outside typical range
100000	Ki	>	100000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 15

External ID: CHEMBL1118592

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL5973
ChEMBL Target Name: Carbonic anhydrase 15
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
37.4	Ki	=	37400	nM
0.089	Ki	=	89	nM
0.078	Ki	=	78	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 14

External ID: CHEMBL1118591

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL3510
ChEMBL Target Name: Carbonic anhydrase XIV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
750	Ki	=	750000	nM	Outside typical range
0.0071	Ki	=	7.1	nM
1.46	Ki	=	1460	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 13

External ID: CHEMBL1118590

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL2186
ChEMBL Target Name: Carbonic anhydrase XIII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
140	Ki	=	140000	nM	Outside typical range
0.994	Ki	=	994	nM
0.047	Ki	=	47	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 12

External ID: CHEMBL1118589

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL3242
ChEMBL Target Name: Carbonic anhydrase XII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
830	Ki	=	830000	nM	Outside typical range
0.0089	Ki	=	8.9	nM
0.0038	Ki	=	3.8	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL3095734

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 24
First Page: 6706
Last Page: 6710
DOI: 10.1016/j.bmcl.2013.10.037

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
4100	Ki	=	4100000	nM	Outside typical range
360	Ki	=	360000	nM	Outside typical range
4200	Ki	=	4200000	nM	Outside typical range
470	Ki	=	470000	nM	Outside typical range
9	Ki	=	9000	nM
2100	Ki	=	2100000	nM	Outside typical range
7	Ki	=	7000	nM
650	Ki	=	650000	nM	Outside typical range
7900	Ki	=	7900000	nM	Outside typical range
4800	Ki	=	4800000	nM	Outside typical range
1200	Ki	=	1200000	nM	Outside typical range
3300	Ki	=	3300000	nM	Outside typical range
2700	Ki	=	2700000	nM	Outside typical range
9200	Ki	=	9200000	nM	Outside typical range
3600	Ki	=	3600000	nM	Outside typical range
2100	Ki	=	2100000	nM	Outside typical range
2500	Ki	=	2500000	nM	Outside typical range
63400	Ki	=	63400000	nM	Outside typical range
4900	Ki	=	4900000	nM	Outside typical range
1000	Ki	=	1000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL1118588

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
9.6	Ki	=	9600	nM
0.081	Ki	=	81	nM
0.058	Ki	=	58	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 7

External ID: CHEMBL1118587

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL2326
ChEMBL Target Name: Carbonic anhydrase VII
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
6.8	Ki	=	6800	nM
0.084	Ki	=	84	nM
9.0E-4	Ki	=	0.9	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 6

External ID: CHEMBL1118586

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2010
Volume: 20
Issue: 12
First Page: 3601
Last Page: 3605
DOI: 10.1016/j.bmcl.2010.04.114

Target ChEMBL ID: CHEMBL3025
ChEMBL Target Name: Carbonic anhydrase VI
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units
70	Ki	=	70000	nM
0.749	Ki	=	749	nM
0.045	Ki	=	45	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 5A, mitochondrial

External ID: CHEMBL828221

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 567
Last Page: 571
DOI: 10.1016/j.bmcl.2004.11.056

Target ChEMBL ID: CHEMBL4789
ChEMBL Target Name: Carbonic anhydrase VA
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
16000	Ki	=	16000000	nM	Outside typical range
95000	Ki	=	95000000	nM	Outside typical range
7120	Ki	=	7120000	nM	Outside typical range
13600	Ki	=	13600000	nM	Outside typical range
11300	Ki	=	11300000	nM	Outside typical range
13000	Ki	=	13000000	nM	Outside typical range
15700	Ki	=	15700000	nM	Outside typical range
687000	Ki	=	687000000	nM	Outside typical range
28200	Ki	=	28200000	nM	Outside typical range
17100	Ki	=	17100000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL828220

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 567
Last Page: 571
DOI: 10.1016/j.bmcl.2004.11.056

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
7000	Ki	=	7000000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
540	Ki	=	540000	nM	Outside typical range
690	Ki	=	690000	nM	Outside typical range
4790	Ki	=	4790000	nM	Outside typical range
95000	Ki	=	95000000	nM	Outside typical range
14600	Ki	=	14600000	nM	Outside typical range
19000	Ki	=	19000000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL3095740

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem Lett
Year: 2013
Volume: 23
Issue: 24
First Page: 6706
Last Page: 6710
DOI: 10.1016/j.bmcl.2013.10.037

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
63000	Ki	=	63000000	nM	Outside typical range
3100	Ki	=	3100000	nM	Outside typical range
1510	Ki	=	1510000	nM	Outside typical range
112000	Ki	=	112000000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
49200	Ki	=	49200000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
830	Ki	=	830000	nM	Outside typical range
920	Ki	=	920000	nM	Outside typical range
48500	Ki	=	48500000	nM	Outside typical range
84	Ki	=	84000	nM
460	Ki	=	460000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
950	Ki	=	950000	nM	Outside typical range
26000	Ki	=	26000000	nM	Outside typical range
760	Ki	=	760000	nM	Potential transcription error
20	Ki	=	20000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Replicase polyprotein 1ab

External ID: CHEMBL4495582

Protocol: N/A

Comment: Target ChEMBL ID: CHEMBL4523582
ChEMBL Target Name: Replicase polyprotein 1ab
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

Data Source: SARS-CoV-2 Screening Data

Standard Type	Standard Relation	Standard Value	Standard Units
Inhibition	=	13.77	%
Inhibition	=	2.35	%
Inhibition	=	21.17	%
Inhibition	=	18.36	%
Inhibition	=	5.381	%
Inhibition	=	18.17	%
Inhibition	=	10.15	%
Inhibition	=	29.56	%
Inhibition	=	18.27	%
Inhibition	=	11.42	%
Inhibition	=	15.4	%
Inhibition	=	7.437	%
Inhibition	=	-3.216	%
Inhibition	=	18	%
Inhibition	=	1.021	%
Inhibition	=	16.4	%
Inhibition	=	2.544	%
Inhibition	=	19.11	%
Inhibition	=	26.15	%
Inhibition	=	5.133	%

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1648933

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg Med Chem
Year: 2011
Volume: 19
Issue: 1
First Page: 243
Last Page: 248
DOI: 10.1016/j.bmc.2010.11.031

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
660	Ki	=	660000	nM	Outside typical range
0.61	Ki	=	610	nM
350	Ki	=	350000	nM	Outside typical range
0.044	Ki	=	44	nM
4.25	Ki	=	4250	nM
330	Ki	=	330000	nM	Outside typical range
5.86	Ki	=	5860	nM
530	Ki	=	530000	nM	Outside typical range
570	Ki	=	570000	nM	Outside typical range
4150	Ki	=	4150000	nM	Outside typical range
850	Ki	=	850000	nM	Outside typical range
66	Ki	=	66000	nM
49	Ki	=	49000	nM
48	Ki	=	48000	nM
39	Ki	=	39000	nM
22	Ki	=	22000	nM
21	Ki	=	21000	nM
60	Ki	=	60000	nM
52	Ki	=	52000	nM
98	Ki	=	98000	nM

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL838843

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 21
First Page: 5435
Last Page: 5439
DOI: 10.1016/j.bmcl.2004.07.086

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
310	Ki	=	310000	nM	Outside typical range
7000	Ki	=	7000000	nM	Outside typical range
0.5	Ki	=	500	nM
31700	Ki	=	31700000	nM	Outside typical range
1.2	Ki	=	1200	nM
63000	Ki	=	63000000	nM	Outside typical range
15000	Ki	=	15000000	nM	Manually validated
8400	Ki	=	8400000	nM	Manually validated
18000	Ki	=	18000000	nM	Manually validated
0.7	Ki	=	700	nM
0.6	Ki	=	600	nM
4000	Ki	=	4000000	nM	Manually validated
6000	Ki	=	6000000	nM	Outside typical range
300000	Ki	>	300000000	nM	Manually validated
300	Ki	=	300000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 5B, mitochondrial

External ID: CHEMBL839467

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 21
First Page: 5435
Last Page: 5439
DOI: 10.1016/j.bmcl.2004.07.086

Target ChEMBL ID: CHEMBL2111457
ChEMBL Target Name: Carbonic anhydrase V
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: D - Direct protein target assigned
Confidence: Multiple direct protein targets may be assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
8.4E-4	Ki	=	0.84	nM	Potential transcription error
0.016	Ki	=	16	nM	Potential transcription error
1.0E-5	Ki	=	0.01	nM
0.00743	Ki	=	7.43	nM
3.0E-4	Ki	=	0.3	nM	Potential transcription error
0.68	Ki	=	680	nM	Potential transcription error
95000	Ki	=	95000000	nM	Outside typical range
16000	Ki	=	16000000	nM	Outside typical range
65000	Ki	=	65000000	nM	Outside typical range
20	Ki	=	20000	nM
2.0E-5	Ki	=	0.02	nM	Potential transcription error
50000	Ki	=	50000000	nM	Outside typical range
0.156	Ki	=	156	nM	Potential transcription error
241000	Ki	=	241000000	nM	Outside typical range
0.025	Ki	=	25	nM	Potential transcription error

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 9

External ID: CHEMBL827388

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 567
Last Page: 571
DOI: 10.1016/j.bmcl.2004.11.056

Target ChEMBL ID: CHEMBL3594
ChEMBL Target Name: Carbonic anhydrase IX
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
46000	Ki	=	46000000	nM	Outside typical range
8.6	Ki	=	8600	nM
147000	Ki	=	147000000	nM	Outside typical range
11600	Ki	=	11600000	nM	Outside typical range
274000	Ki	=	274000000	nM	Outside typical range
49700	Ki	=	49700000	nM	Outside typical range
30300	Ki	=	30300000	nM	Outside typical range
22800	Ki	=	22800000	nM	Outside typical range
2750	Ki	=	2750000	nM	Outside typical range
23900	Ki	=	23900000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 4

External ID: CHEMBL827387

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 567
Last Page: 571
DOI: 10.1016/j.bmcl.2004.11.056

Target ChEMBL ID: CHEMBL3729
ChEMBL Target Name: Carbonic anhydrase IV
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
58700	Ki	=	58700000	nM	Outside typical range
5700	Ki	=	5700000	nM	Outside typical range
64900	Ki	=	64900000	nM	Outside typical range
767000	Ki	=	767000000	nM	Outside typical range
128000	Ki	=	128000000	nM	Outside typical range
108700	Ki	=	108700000	nM	Outside typical range
226000	Ki	=	226000000	nM	Outside typical range
5160	Ki	=	5160000	nM	Outside typical range
2150	Ki	=	2150000	nM	Outside typical range
15900	Ki	=	15900000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL827386

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2005
Volume: 15
Issue: 3
First Page: 567
Last Page: 571
DOI: 10.1016/j.bmcl.2004.11.056

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
35000	Ki	=	35000000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
850	Ki	=	850000	nM	Outside typical range
1260	Ki	=	1260000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
48900	Ki	=	48900000	nM	Outside typical range
75800	Ki	=	75800000	nM	Outside typical range
50400	Ki	=	50400000	nM	Outside typical range
2680	Ki	=	2680000	nM	Outside typical range
31000	Ki	=	31000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase

External ID: CHEMBL828021

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem. Lett.
Year: 2004
Volume: 14
Issue: 17
First Page: 4563
Last Page: 4567
DOI: 10.1016/j.bmcl.2004.06.073

Target ChEMBL ID: CHEMBL3926
ChEMBL Target Name: Carbonic anhydrase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
520	Ki	=	520000	nM	Outside typical range
103000	Ki	=	103000000	nM	Outside typical range
7800	Ki	=	7800000	nM	Outside typical range
700	Ki	=	700000	nM	Outside typical range
27800	Ki	=	27800000	nM	Outside typical range
55700	Ki	=	55700000	nM	Outside typical range
950000	Ki	=	950000000	nM	Outside typical range
44900	Ki	=	44900000	nM	Outside typical range
9600	Ki	=	9600000	nM	Outside typical range
44800	Ki	=	44800000	nM	Outside typical range
330	Ki	=	330000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：BindingDB 靶标：N/A

External ID: BindingDB_3021_1

Protocol: N/A

Comment: Compounds with any of Ki, IC50, Kd, or EC50 activity value <= 10uM are labeled as "Active".
If multiple measurements are available for a given compound, it is labeled as "Active" if any of the measurements meet the criterion. Activity values are checked in the order of Ki, IC50, Kd, and EC50. The first entry that meets the above activity threshold is used to determine "Standard Type", "Standard Relation", and "PubChem Standard Value". Otherwise, the first non-empty entry will be used to set those values.

Standard Type	PubChem Standard Value	Ki	Target Accession(s)	Ligand	Target
Ki	54.4	54400	Q99N23	BDBM26978	Carbonic anhydrase 15 [19-324]
Ki	6000	6000000	P00915	BDBM26979	Carbonic anhydrase 1
Ki	200000	200000000	P00918	BDBM26979	Carbonic anhydrase 2
Ki	90	90000	P22748	BDBM26979	Carbonic anhydrase 4
Ki	85.3	85300	Q99N23	BDBM26979	Carbonic anhydrase 15 [19-324]
Ki	4000	4000000	P00915	BDBM26980	Carbonic anhydrase 1
Ki	63000	63000000	P00918	BDBM26980	Carbonic anhydrase 2
Ki	90	90000	P22748	BDBM26980	Carbonic anhydrase 4
Ki	104	104000	Q99N23	BDBM26980	Carbonic anhydrase 15 [19-324]
Ki	300	300000	P00915	BDBM26981	Carbonic anhydrase 1
Ki	26000	26000000	P00918	BDBM26981	Carbonic anhydrase 2
Ki	80	80000	P22748	BDBM26981	Carbonic anhydrase 4
Ki	288	288000	Q99N23	BDBM26981	Carbonic anhydrase 15 [19-324]
Ki	0.7	700	P00915	BDBM26982	Carbonic anhydrase 1
Ki	30	30000	P00918	BDBM26982	Carbonic anhydrase 2
Ki	610	610000	P22748	BDBM26982	Carbonic anhydrase 4
Ki	27.6	27600	Q99N23	BDBM26982	Carbonic anhydrase 15 [19-324]
Ki	200	200000	P00915	BDBM26983	Carbonic anhydrase 1
Ki	1600	1600000	P00918	BDBM26983	Carbonic anhydrase 2
Ki	39000	39000000	P22748	BDBM26983	Carbonic anhydrase 4

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 1

External ID: CHEMBL1693485

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 6
First Page: 1847
Last Page: 1851
DOI: 10.1016/j.bmc.2011.02.015

Target ChEMBL ID: CHEMBL261
ChEMBL Target Name: Carbonic anhydrase I
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.25	Ki	=	250	nM
0.328	Ki	=	328	nM
0.056	Ki	=	56	nM
0.015	Ki	=	15	nM
18.54	Ki	=	18540	nM
8400	Ki	=	8400000	nM	Outside typical range
1.2	Ki	=	1200	nM
310	Ki	=	310000	nM	Outside typical range
12000	Ki	=	12000000	nM	Outside typical range
15000	Ki	=	15000000	nM	Outside typical range
63000	Ki	=	63000000	nM	Outside typical range
21	Ki	=	21000	nM
300000	Ki	>	300000000	nM	Outside typical range
6000	Ki	=	6000000	nM	Outside typical range
50	Ki	=	50000	nM
45	Ki	=	45000	nM
4000	Ki	=	4000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
0.7	Ki	=	700	nM
300	Ki	=	300000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Carbonic anhydrase 2

External ID: CHEMBL1693486

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem.
Year: 2011
Volume: 19
Issue: 6
First Page: 1847
Last Page: 1851
DOI: 10.1016/j.bmc.2011.02.015

Target ChEMBL ID: CHEMBL205
ChEMBL Target Name: Carbonic anhydrase II
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: D - Direct protein target assigned
Confidence: Direct single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
0.012	Ki	=	12	nM
0.29	Ki	=	290	nM
0.035	Ki	=	35	nM
0.009	Ki	=	9	nM
5.95	Ki	=	5950	nM
63000	Ki	=	63000000	nM	Outside typical range
1500	Ki	=	1500000	nM	Outside typical range
1130	Ki	=	1130000	nM	Outside typical range
85000	Ki	=	85000000	nM	Outside typical range
73000	Ki	=	73000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
390	Ki	=	390000	nM	Outside typical range
300000	Ki	>	300000000	nM	Outside typical range
200000	Ki	=	200000000	nM	Outside typical range
0.009	Ki	=	9	nM
0.003	Ki	=	3	nM
63000	Ki	=	63000000	nM	Outside typical range
200000	Ki	>	200000000	nM	Outside typical range
30	Ki	=	30000	nM
26000	Ki	=	26000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL2340375

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: Bioorg. Med. Chem. Lett.
Year: 2013
Volume: 23
Issue: 6
First Page: 1636
Last Page: 1638
DOI: 10.1016/j.bmcl.2013.01.084

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
43	Ki	=	43000	nM
760	Ki	=	760000	nM	Outside typical range
60800	Ki	=	60800000	nM	Outside typical range
8	Ki	=	8000	nM
5130	Ki	=	5130000	nM	Outside typical range
23	Ki	=	23000	nM
4640	Ki	=	4640000	nM	Outside typical range
850	Ki	=	850000	nM	Outside typical range
800	Ki	=	800000	nM	Outside typical range
5320	Ki	=	5320000	nM	Outside typical range
14500	Ki	=	14500000	nM	Outside typical range
2960	Ki	=	2960000	nM	Outside typical range
84100	Ki	=	84100000	nM	Outside typical range
88200	Ki	=	88200000	nM	Outside typical range
88	Ki	=	88000	nM
16600	Ki	=	16600000	nM	Outside typical range
75	Ki	=	75000	nM
9730	Ki	=	9730000	nM	Outside typical range
33	Ki	=	33000	nM
74	Ki	=	74000	nM

7803-58-9 靶点实验数据