HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dihydropteridine reductase

External ID: CHEMBL669212

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1985
Volume: 28
Issue: 3
First Page: 311
Last Page: 317
DOI: 10.1021/jm00381a009

Target ChEMBL ID: CHEMBL3730
ChEMBL Target Name: Dihydropteridine reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
23000	IC50	=	23000000	nM	Outside typical range
9.3	IC50	=	9300	nM
3	IC50	=	3000	nM
5.9	IC50	=	5900	nM
9400	IC50	=	9400000	nM	Outside typical range
2400	IC50	=	2400000	nM	Outside typical range
10000	IC50	=	10000000	nM	Outside typical range
0.63	IC50	=	630	nM
5300	IC50	=	5300000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Amine oxidase [flavin-containing] B

External ID: CHEMBL734660

Protocol: N/A

Comment: Journal: J. Med. Chem.
Year: 1993
Volume: 36
Issue: 20
First Page: 2929
Last Page: 2937
DOI: 10.1021/jm00072a012

Target ChEMBL ID: CHEMBL2095205
ChEMBL Target Name: Monoamine oxidase
ChEMBL Target Type: PROTEIN FAMILY - Target is a group of closely related proteins
Relationship Type: H - Homologous protein target assigned
Confidence: Multiple homologous protein targets may be assigned

Standard Type	Standard Relation	Standard Value
Relative activity	=	3
Relative activity	=	2
Relative activity	=	3
Relative activity	=	2
Relative activity	=	3
Relative activity	=	3
Relative activity	=	3
Relative activity	=	3
Relative activity	=	2
Relative activity	=	3
Relative activity	=	2
Relative activity	=	3
Relative activity	=	2
Relative activity	=	2
Relative activity	=	3
Relative activity	=	1
Relative activity	=	2
Relative activity	=	2
Relative activity	=	2
Relative activity	=	3

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：Dihydropteridine reductase

External ID: CHEMBL669215

Protocol: N/A

Comment: Compounds with activity <= 10uM or explicitly reported as active by ChEMBL are flagged as active in this PubChem assay presentation.

Journal: J. Med. Chem.
Year: 1985
Volume: 28
Issue: 3
First Page: 311
Last Page: 317
DOI: 10.1021/jm00381a009

Target ChEMBL ID: CHEMBL2910
ChEMBL Target Name: Dihydropteridine reductase
ChEMBL Target Type: SINGLE PROTEIN - Target is a single protein chain
Relationship Type: H - Homologous protein target assigned
Confidence: Homologous single protein target assigned

PubChem Standard Value	Standard Type	Standard Relation	Standard Value	Standard Units	Data Validity Comment
12000	IC50	=	12000000	nM	Outside typical range
5.8	IC50	=	5800	nM
2.6	IC50	=	2600	nM
3.4	IC50	=	3400	nM
7400	IC50	=	7400000	nM	Outside typical range
1900	IC50	=	1900000	nM	Outside typical range
12000	IC50	=	12000000	nM	Outside typical range
1.6	IC50	=	1600	nM
2000	IC50	=	2000000	nM	Outside typical range

HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set16

来源：ChEMBL 靶标：N/A

External ID: CHEMBL1167579

Protocol: N/A

Comment: Journal: Bioorg. Med. Chem.
Year: 2010
Volume: 18
Issue: 11
First Page: 4111
Last Page: 4118
DOI: 10.1016/j.bmc.2010.03.079

Standard Type	Standard Relation	Standard Value	Standard Units	Activity Comment
Vmax				Not Active

774-52-7 靶点实验数据